3,097 research outputs found
Near-Infrared, Adaptive Optics Observations of the T Tauri Multiple-Star System
With high-angular-resolution, near-infrared observations of the young stellar
object T Tauri at the end of 2002, we show that, contrary to previous reports,
none of the three infrared components of T Tau coincide with the compact radio
source that has apparently been ejected recently from the system (Loinard,
Rodriguez, and Rodriguez 2003). The compact radio source and one of the three
infrared objects, T Tau Sb, have distinct paths that depart from orbital or
uniform motion between 1997 and 2000, perhaps indicating that their interaction
led to the ejection of the radio source. The path that T Tau Sb took between
1997 and 2003 may indicate that this star is still bound to the presumably more
massive southern component, T Tau Sa. The radio source is absent from our
near-infrared images and must therefore be fainter than K = 10.2 (if located
within 100 mas of T Tau Sb, as the radio data would imply), still consistent
with an identity as a low-mass star or substellar object.Comment: 11 pages, 3 figures, submitted to ApJ
Coulomb oscillations in three-layer graphene nanostructures
We present transport measurements on a tunable three-layer graphene single
electron transistor (SET). The device consists of an etched three-layer
graphene flake with two narrow constrictions separating the island from source
and drain contacts. Three lateral graphene gates are used to electrostatically
tune the device. An individual three-layer graphene constriction has been
investigated separately showing a transport gap near the charge neutrality
point. The graphene tunneling barriers show a strongly nonmonotonic coupling as
function of gate voltage indicating the presence of localized states in the
constrictions. We show Coulomb oscillations and Coulomb diamond measurements
proving the functionality of the graphene SET. A charging energy of meV is extracted.Comment: 10 pages, 6 figure
Lattice Model for water-solute mixtures
A lattice model for the study of mixtures of associating liquids is proposed.
Solvent and solute are modeled by adapting the associating lattice gas (ALG)
model. The nature of interaction solute/solvent is controlled by tuning the
energy interactions between the patches of ALG model. We have studied three set
of parameters, resulting on, hydrophilic, inert and hydrophobic interactions.
Extensive Monte Carlo simulations were carried out and the behavior of pure
components and the excess properties of the mixtures have been studied. The
pure components: water (solvent) and solute, have quite similar phase diagrams,
presenting: gas, low density liquid, and high density liquid phases. In the
case of solute, the regions of coexistence are substantially reduced when
compared with both the water and the standard ALG models. A numerical procedure
has been developed in order to attain series of results at constant pressure
from simulations of the lattice gas model in the grand canonical ensemble. The
excess properties of the mixtures: volume and enthalpy as the function of the
solute fraction have been studied for different interaction parameters of the
model. Our model is able to reproduce qualitatively well the excess volume and
enthalpy for different aqueous solutions. For the hydrophilic case, we show
that the model is able to reproduce the excess volume and enthalpy of mixtures
of small alcohols and amines. The inert case reproduces the behavior of large
alcohols such as, propanol, butanol and pentanol. For last case (hydrophobic),
the excess properties reproduce the behavior of ionic liquids in aqueous
solution.Comment: 28 pages, 13 figure
Indecomposable U_q(sl_n) modules for q^h = -1 and BRS intertwiners
A class of indecomposable representations of U_q(sl_n) is considered for q an
even root of unity (q^h = -1) exhibiting a similar structure as (height h)
indecomposable lowest weight Kac-Moody modules associated with a chiral
conformal field theory. In particular, U_q(sl_n) counterparts of the
Bernard-Felder BRS operators are constructed for n=2,3. For n=2 a pair of dual
d_2(h) = h dimensional U_q(sl_2) modules gives rise to a 2h-dimensional
indecomposable representation including those studied earlier in the context of
tensor product expansions of irreducible representations. For n=3 the interplay
between the Poincare'-Birkhoff-Witt and (Lusztig) canonical bases is exploited
in the study of d_3(h) = h(h+1)(2h+1)/6 dimensional indecomposable modules and
of the corresponding intertwiners.Comment: 31 pages, LaTeX, amsfonts, amssym
Caspase-independent programmed cell death triggers Ca2PO4 deposition in an in vitro model of nephrocalcinosis
We provide evidence of caspase-independent cell death triggering the calcification process in GDNF-silenced HK-2 cells
Ruling out Stellar Companions and Resolving the Innermost Regions of Transitional Disks with the Keck Interferometer
With the Keck Interferometer, we have studied at 2 um the innermost regions
of several nearby, young, dust depleted "transitional" disks. Our observations
target five of the six clearest cases of transitional disks in the
Taurus/Auriga star-forming region (DM Tau, GM Aur, LkCa 15, UX Tau A, and RY
Tau) to explore the possibility that the depletion of optically thick dust from
the inner disks is caused by stellar companions rather than the more typical
planet-formation hypothesis. At the 99.7% confidence level, the observed
visibilities exclude binaries with flux ratios of at least 0.05 and separations
ranging from 2.5 to 30 mas (0.35 - 4 AU) over >= 94% of the area covered by our
measurements. All targets but DM Tau show near-infrared excess in their SED
higher than our companion flux ratio detection limits. While a companion has
previously been detected in the candidate transitional disk system CoKu Tau/4,
we can exclude similar mass companions as the typical origin for the clearing
of inner dust in transitional disks and of the near-infrared excess emission.
Unlike CoKu Tau/4, all our targets show some evidence of accretion. We find
that all but one of the targets are clearly spatially resolved, and UX Tau A is
marginally resolved. Our data is consistent with hot material on small scales
(0.1 AU) inside of and separated from the cooler outer disk, consistent with
the recent SED modeling. These observations support the notion that some
transitional disks have radial gaps in their optically thick material, which
could be an indication for planet formation in the habitable zone (~ a few AU)
of a protoplanetary disk.Comment: 36 pages, 7 figures. Accepted for publication in Ap
Dose escalation of desmoteplase for acute ischemic stroke (DEDAS): evidence of safety and efficacy 3 to 9 hours after stroke onset
<p><b>Background and Purpose:</b> Desmoteplase is a novel plasminogen activator with favorable features in vitro compared with available agents. This study evaluated safety and efficacy of intravenous (IV) desmoteplase in patients with perfusion/diffusion mismatch on MRI 3 to 9 hours after onset of acute ischemic stroke.</p>
<p><b>Methods:</b> DEDAS was a placebo-controlled, double-blind, randomized, dose-escalation study investigating doses of 90 μg/kg and 125 μg/kg desmoteplase. Eligibility criteria included baseline National Institute of Health Stroke Scale (NIHSS) scores of 4 to 20 and MRI evidence of perfusion/diffusion mismatch. The safety end point was the rate of symptomatic intracranial hemorrhage. Primary efficacy co-end points were MRI reperfusion 4 to 8 hours after treatment and good clinical outcome at 90 days. The primary analyses were intent-to-treat. Before unblinding, a target population, excluding patients violating specific MRI criteria, was defined.</p>
<p><b>Results:</b> Thirty-seven patients were randomized and received treatment (intent-to-treat; placebo: n=8; 90 μg/kg: n=14; 125 μg/kg: n=15). No symptomatic intracranial hemorrhage occurred. Reperfusion was achieved in 37.5% (95% CI [8.5; 75.5]) of placebo patients, 18.2% (2.3; 51.8) of patients treated with 90 μg/kg desmoteplase, and 53.3% (26.6; 78.7) of patients treated with 125 μg/kg desmoteplase. Good clinical outcome at 90 days occurred in 25.0% (3.2; 65.1) treated with placebo, 28.6% (8.4; 58.1) treated with 90 μg/kg desmoteplase and 60.0% (32.3; 83.7) treated with 125 μg/kg desmoteplase. In the target population (n=25), the difference compared with placebo increased and was statistically significant for good clinical outcome with 125 μg/kg desmoteplase (P=0.022).</p>
<p><b>Conclusions:</b> Treatment with IV desmoteplase 3 to 9 hours after ischemic stroke onset appears safe. At a dose of 125 μg/kg desmoteplase appeared to improve clinical outcome, especially in patients fulfilling all MRI criteria. The results of DEDAS generally support the results of its predecessor study, Desmoteplase in Acute Ischemic Stroke (DIAS).</p>
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