666 research outputs found
Manipulation of ultracold atomic mixtures using microwave techniques
We used microwave radiation to evaporatively cool a mixture of of 133Cs and
87Rb atoms in a magnetic trap. A mixture composed of an equal number (around
10^4) of Rb and Cs atoms in their doubly polarized states at ultracold
temperatures was prepared. We also used microwaves to selectively evaporate
atoms in different Zeeman states.Comment: 9 pages, 6 figure
Deep-well ultrafast manipulation of a SQUID flux qubit
Superconducting devices based on the Josephson effect are effectively used
for the implementation of qubits and quantum gates. The manipulation of
superconducting qubits is generally performed by using microwave pulses with
frequencies from 5 to 15 GHz, obtaining a typical operating clock from 100MHz
to 1GHz. A manipulation based on simple pulses in the absence of microwaves is
also possible. In our system a magnetic flux pulse modifies the potential of a
double SQUID qubit from a symmetric double well to a single deep well
condition. By using this scheme with a Nb/AlOx/Nb system we obtained coherent
oscillations with sub-nanosecond period (tunable from 50ps to 200ps), very fast
with respect to other manipulating procedures, and with a coherence time up to
10ns, of the order of what obtained with similar devices and technologies but
using microwave manipulation. We introduce the ultrafast manipulation
presenting experimental results, new issues related to this approach (such as
the use of a feedback procedure for cancelling the effect of "slow"
fluctuations), and open perspectives, such as the possible use of RSFQ logic
for the qubit control.Comment: 9 pages, 7 figure
Evaluating case studies of community-oriented integrated care.
This paper summarises a ten-year conversation within London Journal of Primary Care about the nature of community-oriented integrated care (COIC) and how to develop and evaluate it. COIC means integration of efforts for combined disease-treatment and health-enhancement at local, community level. COIC is similar to the World Health Organisation concept of a Community-Based Coordinating Hub - both require a local geographic area where different organisations align their activities for whole system integration and develop local communities for health. COIC is a necessary part of an integrated system for health and care because it enables multiple insights into 'wicked problems', and multiple services to integrate their activities for people with complex conditions, at the same time helping everyone to collaborate for the health of the local population. The conversation concludes seven aspects of COIC that warrant further attention
An Optimal Tunable Josephson Element for Quantum Computing
We introduce a three-junction SQUID that can be effectively used as an
optimal tunable element in Josephson quantum computing applications. This
device can replace the simple dc SQUID generally used as tunable element in
this kind of applications, with a series of advantages for the coherence time
and for the tolerance to small errors. We study the device both theoretically
and experimentally at 4.2 K, obtaining a good agreement between the results.Comment: 3 pages, 4 figure
Novel mutations in DNA2 associated with myopathy and mtDNA instability
The maintenance of mitochondrial DNA (mtDNA) relies on proteins encoded by nuclear genes. Mutations in their coding sequences result in heterogenous clinical presentations featuring mtDNA instability in affected tissues. DNA2 is a multi-catalytic protein involved in the removal of single strand DNA during mtDNA replication or Long Patch Base Excision Repair pathway. We have previously described DNA2 mutations in adult patients affected with familial and sporadic forms of mitochondrial myopathy. Here we describe four novel probands presenting with limb weakness associated with novel DNA2 molecular defects. Biochemical assays were established to investigate the functional effects of these variants
Effect of cosmic rays on the resonant gravitational wave detector NAUTILUS at temperature T=1.5 K
The interaction between cosmic rays and the gravitational wave bar detector
NAUTILUS is experimentally studied with the aluminum bar at temperature of
T=1.5 K. The results are compared with those obtained in the previous runs when
the bar was at T=0.14 K. The results of the run at T = 1.5 K are in agreement
with the thermo-acoustic model; no large signals at unexpected rate are
noticed, unlike the data taken in the run at T = 0.14 K. The observations
suggest a larger efficiency in the mechanism of conversion of the particle
energy into vibrational mode energy when the aluminum bar is in the
superconductive status.Comment: 7 pages, 3 figures, 2 tables. Accepted by Physics Letters
Novel mutations in DNA2 associated with myopathy and mtDNA instability
The maintenance of mitochondrial DNA (mtDNA) relies on proteins encoded by nuclear genes. Mutations in their coding sequences result in heterogenous clinical presentations featuring mtDNA instability in affected tissues. DNA2 is a multi-catalytic protein involved in the removal of single strand DNA during mtDNA replication or Long Patch Base Excision Repair pathway. We have previously described DNA2 mutations in adult patients affected with familial and sporadic forms of mitochondrial myopathy. Here we describe four novel probands presenting with limb weakness associated with novel DNA2 molecular defects. Biochemical assays were established to investigate the functional effects of these variants
Co-occurrence of amyotrophic lateral sclerosis and Leber's hereditary optic neuropathy: is mitochondrial dysfunction a modifier?
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