BASS. XXXV. The MBH-σ* Relation of 105 Month Swift-BAT Type 1 AGNs

We present two independent measurements of stellar velocity dispersions (sigma(star)) from the Ca II H+K lambda 3969, 3934 and Mg I b lambda 5183, 5172, 5167 region (3880-5550 angstrom) and the calcium triplet region (8350-8750 angstrom) for 173 hard X-ray-selected Type 1 active galactic nuclei (AGNs; z <= 0.08) from the 105 month Swift-BAT catalog. We construct one of the largest samples of local Type 1 AGNs that have both single-epoch virial black hole mass (M-BH) estimates and sigma(star) measurements obtained from high spectral resolution data, allowing us to test the usage of such methods for supermassive black hole studies. We find that the two independent sigma(star) measurements are highly consistent with each other, with an average offset of only 0.002 +/- 0.001 dex. Comparing M-BH estimates based on broad emission lines and stellar velocity dispersion measurements, we find that the former is systematically lower by approximate to 0.12 dex. Consequently, Eddington ratios estimated through broad-line MBH determinations are similarly biased (but in the opposite way). We argue that the discrepancy is driven by extinction in the broad-line region. We also find an anticorrelation between the offset from the M-BH-sigma(star) relation and the Eddington ratio. Our sample of Type 1 AGNs shows a shallower M-BH-sigma(star) relation (with a power-law exponent of approximate to 3.5) compared with that of inactive galaxies (with a power-law exponent of approximate to 4.5), confirming earlier results obtained from smaller samples

The impact of TFPI on coronary atherosclerotic burden

WOS: 000436626500011PubMed ID: 29947240OBJECTIVES: We aimed to associate a coronary artery disease (CAD) presence and severity with endothelial dysfunction (ED), carotid intima media thickness (CIMT) and Tissue Factor Pathway Inhibitor (TFPI). BACKGROUND: ED has a central role in atherosclerosis. CIMT and TFPI activity are also related with atherosclerosis and CAD. METHODS: In our prospective observational study, 50 patients had CAD and 30 had normal coronary arteries. Endothelial function was evaluated by endothelium-dependent flow-mediated dilatation (FMD) and nitroglycerinemediated dilatation (NMD) measurements. CIMT and Serum TFPI levels were also measured. RESULTS: TFPI was a statistically significant determinant between the two groups with an increased level in CAD (+) group (84.9 +/- 19.3 vs 70.2 +/- 14.7, p = 0.001). There was a positive correlation between CIMT and Gensini (r = 0.34, p = 0.014). There was a strong negative correlation between Gensini and FMD-NMD, statistically significant (FMD: r =-0.715, p < 0.001; NMD: r = -0.718, p < 0.001). CONCLUSION: We observed that ED, increased CIMT and TFPI levels were associated with CAD. Additionally, increased CIMT measurements and decreased FMD and NMD values had a positive correlation with GSS (Tab. 4, Fig. 6, Ref. 50). Text in PDF www.elis.sk

Relationships between visceral/subcutaneous adipose tissue FABP4 expression and coronary atherosclerosis in patients with metabolic syndrome

Gormez, Selcuk/0000-0002-3546-3369WOS: 000520851300009PubMed: 31927390Background: Cytoplasmic fatty acid-binding proteins facilitate the transport of lipids to specific compartments in cells. Fatty acid-binding protein 4 (FABP4), also known as aP2 or A-FABP, plays a key role in the development of atherosclerosis, insulin resistance, obesity, and metabolic syndrome (MS). the FABP4 polymorphisms are associated with protein expression changes in vitro and metabolic and vascular alterations in vivo. the aim of this study was to investigate the association between FABP4 messenger ribonucleic acid (mRNA) expression levels in epicardial (EAT), pericardial (PAT), and subcutaneous adipose tissues (SAT), and the extent of coronary atherosclerosis in coronary artery disease (CAD) patients with MS. Furthermore, the relationship between the extent of coronary atherosclerosis and epicardial adipose tissue volume (EATV) and FABP4 gene variations was evaluated. Patients and methods: A total of 37 patients undergoing coronary artery bypass grafting because of CAD (MS CAD group) and 23 non-MS patients undergoing heart valve surgery (control group) were included. Coronary angiography was performed for all patients and the extent of coronary atherosclerosis was assessed using the Sullivan's scoring system. the mRNA expression levels of FABP4 gene in EAT, PAT, and SAT, and FABP4 polymorphisms were analyzed using the quantitative real-time polymerase chain reaction (qRT-PCR). Results: An increased FABP4 expression was observed in EAT and PAT of MS CAD group compared to controls. in the MS CAD group, FABP4 mRNA expression levels in EAT was 2.8-fold higher compared to PAT. the expression of FABP4 in EAT was positively correlated with the extent of atherosclerosis and EATV in MS CAD group (r = 0.588, P = 0.001, r = 0.174, P = 0.001, respectively). There were no correlations between PAT and SAT versus the extent of atherosclerosis and EATV. the FABP4 EAT mRNA expression levels were found to significantly increase in mutant allele carriers of rs1054135, whereas they significantly decreased in mutant allele carriers of rs77878271 (T-87C) in MS CAD group (P < 0.05). the extent of atherosclerosis was also found to be significantly associated with rs1054135 (P < 0.05). A cut-off point of 57.5 cm(3) EATV was used indicating the presence of CAD with a significant area under the curve of 0.783%, 98% sensitivity, and 100% specificity (95% CI 0.620-0.880; P < 0.05). Conclusions: Our study results suggest that FABP4 expression in EAT is strongly associated with the extent of atherosclerosis and EATV in MS CAD patients. (C) 2019 Published by Elsevier Inc.Turkish Diabetes FoundationThe authors would like to thank to the late Prof. Ahmet Sevim Buyukdevrim for his valuable support and advice to the manuscript. This work was supported by Turkish Diabetes Foundation

Physician-nurse attitudes toward collaboration in Istanbul's public hospitals

The need for greater collaboration between nurses and physicians in clinical practice is essential to improve patient care and worker satisfaction. This study used t-tests and logistic regression to test four research hypotheses concerning attitudes toward physician-nurse collaboration in Istanbul, Turkey. The study found that nurses express more positive attitudes toward collaboration than physicians. Noteworthy was the finding that male physicians expressed more positive attitudes toward collaboration than female physicians. Residents and those employed in secondary institutions were also more likely to express more positive attitudes toward collaboration than permanent physicians and those employed in tertiary hospitals. (c) 2004 Elsevier Ltd. All rights reserved

Physician-nurse attitudes toward collaboration in Istanbul's public hospitals

The need for greater collaboration between nurses and physicians in clinical practice is essential to improve patient care and worker satisfaction. This study used t-tests and logistic regression to test four research hypotheses concerning attitudes toward physician-nurse collaboration in Istanbul, Turkey. The study found that nurses express more positive attitudes toward collaboration than physicians. Noteworthy was the finding that male physicians expressed more positive attitudes toward collaboration than female physicians. Residents and those employed in secondary institutions were also more likely to express more positive attitudes toward collaboration than permanent physicians and those employed in tertiary hospitals. (c) 2004 Elsevier Ltd. All rights reserved