Development of pulse-width-modulation techniques for multi-phase and multi-leg voltage source inverters

A huge body of work has been published in recent times in the area of multi-phase machines and drives. Many aspects of these drives have been analysed, such as reduction of torque pulsations, increased reliability and fault tolerance, improved power sharing capabilities and possibilities for realisation of series-connected multi-motor drives with supply coming from a single multi-phase voltage source inverter (VSI). Various pulse width modulation (PWM) schemes have been developed for multi-phase machines with concentrated and distributed windings, utilising both carrier-based PWM and space vector PWM (SVPWM) approaches. However, no systematic analysis has been performed in order to determine properties of multi-phase PWM in general, and to establish close correlation between carrier-based PWM and space vertor PWM, for multi-phase VSIs. This thesis presents an analysis and development of multi-phase PWM schemes for sinusoidal output voltage generation with two-level muhi-phase VSIs, which are suitable for multi-phase machines with distributed windings. Therefore, attention is paid to the elimination of low order harmonics. The scope of the thesis has been narrowed down to the continuous PWM schemes and operation in the linear region of the modulation only. Both multi-phase carrier-based PWM and SVPWM schemes are considered, and, in particular, five-phase, seven-phase e-phase systems are addressed in detail. Thus, a strong link between these two different approaches is established, allowing for an easier comparison of the features offered by each method. All PWM schemes are practically implemented in a DSP and experimentally verified through extensive experimentation on the custom-built multi-phase VSI. In addition to the methods of sinusoidal output voltage generation, achieved by means of the synthesis of the reference in only the first plane of the multi-phase system with simultaneous zeroing of voltages in all the other planes

Sympathetic neural activation: An ordered affair

Is there an ordered pattern in the recruitment of postganglionic sympathetic neurones? Using new multi-unit action potential detection and analysis techniques we sought to determine whether the activation of sympathetic vasomotor neurones during stress is governed by the size principle of recruitment. Multi-unit postganglionic sympathetic activity (fibular nerve) was collected from five male subjects at rest and during periods of elevated sympathetic stress (end-inspiratory apnoeas; 178 ± 37 s(mean ± S.D.)). Compared to baseline (0.24 ± 0.04 V), periods of elevated stress resulted in augmented sympathetic burst size (1.34 ± 0.38 V, P \u3c 0.05). Increased burst size was directly related to both the number of action potentials within a multi-unit burst of postganglionic sympathetic activity (r= 0.88 ± 0.04, P \u3c 0.001 in all subjects), and the amplitude of detected action potentials (r= 0.88 ± 0.06, P \u3c 0.001 in all subjects). The recruitment of larger, otherwise silent, neurons accounted for approximately 74% of the increase in detected action potentials across burst sizes. Further, action potential conduction velocities (inverse of latencies) were increased as a function of action potential size (R2= 0.936, P= 0.001). As axon diameter is positively correlated with action potential size and conduction velocity, these data suggest that the principle of ordered recruitment based on neuronal size applies to postganglionic sympathetic vasomotor neurones. This information may be pertinent to our understanding of reflex-specific recruitment strategies in postganglionic sympathetic nerves, patterns of vasomotor control during stress, and the malleability of sympathetic neuronal properties and recruitment in health and disease.The sympathetic nervous system is an important controller of blood pressure and blood flow to critical tissues and organs. In other neural systems (e.g. the skeletal motor system) there is a well understood pattern of neural recruitment during activation. Alternatively, our understanding of how sympathetic neurones are coordinated during stress is limited. We demonstrate that during stress otherwise silent sympathetic neurones are activated in an order based on neuronal size (from smallest to largest). This recruitment pattern is similar to what is known in other neural systems. This information has important implications for how blood pressure and blood flow are controlled, and the malleability of sympathetic activation in health and disease. © 2010 The Authors. Journal compilation © 2010 The Physiological Society

Ventilation-perfusion inequality in the human lung is not increased following no-decompression-stop hyperbaric exposure

Venous gas bubbles occur in recreational SCUBA divers in the absence of decompression sickness, forming venous gas emboli (VGE) which are trapped within pulmonary circulation and cleared by the lung without overt pathology. We hypothesized that asymptomatic VGE would transiently increase ventilation-perfusion mismatch due to their occlusive effects within the pulmonary circulation. Two sets of healthy volunteers (n = 11, n = 12) were recruited to test this hypothesis with a single recreational ocean dive or a baro-equivalent dry hyperbaric dive. Pulmonary studies (intrabreath VA/Q (iV/Q), alveolar dead space, and FVC) were conducted at baseline and repeat 1- and 24-h after the exposure. Contrary to our hypothesis VA/Q mismatch was decreased 1-h post-SCUBA dive (iV/Q slope 0.023 ± 0.008 ml−1 at baseline vs. 0.010 ± 0.005 NS), and was significantly reduced 24-h post-SCUBA dive (0.000 ± 0.005, p < 0.05), with improved VA/Q homogeneity inversely correlated to dive severity. No changes in VA/Q mismatch were observed after the chamber dive. Alveolar dead space decreased 24-h post-SCUBA dive (78 ± 10 ml at baseline vs. 56 ± 5, p < 0.05), but not 1-h post dive. FVC rose 1-h post-SCUBA dive (5.01 ± 0.18 l vs. 5.21 ± 0.26, p < 0.05), remained elevated 24-h post SCUBA dive (5.06 ± 0.2, p < 0.05), but was decreased 1-hr after the chamber dive (4.96 ± 0.31 L to 4.87 ± 0.32, p < 0.05). The degree of VA/Q mismatch in the lung was decreased following recreational ocean dives, and was unchanged following an equivalent air chamber dive, arguing against an impact of VGE on the pulmonary circulation

Multi-Variable High-Frequency Input-Admittance of Grid-Connected Converters: Modeling, Validation and Implications on Stability

Modern grids are facing a massive integration of power electronics devices, usually associated to instability issues. In order to assess the likelihood and severity of harmonic instability in the high frequency region, this work develops a multi-variable input-admittance model that accurately reflects the following aspects: i) the discrete controller frequencies are defined inside a spectrum region limited by the Nyquist frequency; ii) the physical system aliases are transformed into lower frequency component inside the discrete controller. The proposed model shows that dynamic interactions are not theoretically band-limited; however, the control action tends to be strongly limited in a low frequency range, due to the natural low-pass filter behavior of acquisition and modulation blocks. This is reflected in a reduced resistive part (either positive or negative) of the input-admittance in the high frequency range. More specifically, considering the input-admittance passivity criterion, the excursions into the non-passive area are very smooth at high frequencies, where the input-admittance is well described by simply its inductive filter. Comprehensive experiments are conducted on a lab scale prototype, which includes measurements beyond the Nyquist frequency and alias identification. The experimental results well match the theoretical model

Dynamic Assessment of Source–Load Interactions in Marine MVDC Distribution

Medium-voltage direct-current (MVDC) distribution is a possible replacement due to the advancements in power electronic technologies, for existing medium-voltage ac distribution on ships. The new systems based on MVDC are expected to increase fuel efficiency, remove bulky low frequency transformers used for voltage coordination, and integrate storage technologies. These expected benefits of MVDC come with challenges such as stability and reliability of the new distribution system. In this paper, the effect of three different source-side converters, based on commercially available technology, on the MVDC distribution grid and their interactions with the constant power loads (propulsion drives) are investigated. Additionally, the effect of variations in the filtering effort and the distribution lengths on the system stability is analyzed using the impedance-based stability assessment

Роль хемокинов в рекрутировании клеток-предшественников в опухолевую нишу при раке молочной железы

Развитие первичной опухоли сопровождается формированием опухолевой ниши, котораясоздает благоприятные условия для выживания и пролиферации раковых клеток. Одним из ключевых элементов эволюции опухолевой ниши является рекрутирование костномозговых клеток-предшественников, включая клетки-предшественники макрофагов, мезенхимальные столовые клетки, эндотелиальные и гемопоэтические клетки-предшественники. Миграция упомянутых клеток в опухоль регулируется рядом хемокинов, в том числе CCL2, CXCL12, MSP (macrophage stimulating protein) и MIF (macrophage inhibitory factor). Целью настоящего исследования являлось изучение параметров опухолевой ниши при раке молочной железы. Исследование включало 24 больных с инвазивной карциномой неспецифического типа молочной железы. В суспензии опухолевых клеток методом проточной цитофлюориметрии определяли содержание клеток-предшественников. Концентрацию хемокинов CCL2, CXCL12, MSP и MIF в венозной крови больных оценивали с помощью твердофазного иммуноферментного анализа. Достоверных различий в содержании исследованных клеточных популяций, а также концентрации изученных хемокинов между пациентами, разделенными на группы взависимости от наличия или отсутствия лимфогенных метастазов и неоадъювантного лечения, обнаружено не было. В то же время, установлена прямая корреляционная связь между содержанием гемопоэтических клеток-предшественников в опухоли и концентрацией CXCL12 и MIF в крови

Input-Admittance Passivity Compliance for Grid-Connected Converters With an LCL Filter

This work presents a design methodology and its experimental validation for the input-admittance passivity compliance of LCL grid-connected converters. The designs of the LCL filter parameters and discrete controller are addressed systematically, and suitable design guidelines are provided. The controller design is developed in the z-domain, with capacitor voltage based active damping used as degree of freedom to compensate for system delay effects. The role of resistive components in the circuit, which have inherent dissipative properties, is also discussed. As an outcome of the design, a passive input admittance shaping is obtained. The theoretical development is further verified in a low-scale prototype supplied from a controllable grid simulator. For the sake of generality, different combinations of resonant to sampling frequency are tested. Experimental results fully prove the input-admittance passivity compliance

Venous gas embolism as a predictive tool for improving CNS decompression safety

A key process in the pathophysiological steps leading to decompression sickness (DCS) is the formation of inert gas bubbles. The adverse effects of decompression are still not fully understood, but it seems reasonable to suggest that the formation of venous gas emboli (VGE) and their effects on the endothelium may be the central mechanism leading to central nervous system (CNS) damage. Hence, VGE might also have impact on the long-term health effects of diving. In the present review, we highlight the findings from our laboratory related to the hypothesis that VGE formation is the main mechanism behind serious decompression injuries. In recent studies, we have determined the impact of VGE on endothelial function in both laboratory animals and in humans. We observed that the damage to the endothelium due to VGE was dose dependent, and that the amount of VGE can be affected both by aerobic exercise and exogenous nitric oxide (NO) intervention prior to a dive. We observed that NO reduced VGE during decompression, and pharmacological blocking of NO production increased VGE formation following a dive. The importance of micro-nuclei for the formation of VGE and how it can be possible to manipulate the formation of VGE are discussed together with the effects of VGE on the organism. In the last part of the review we introduce our thoughts for the future, and how the enigma of DCS should be approached