Consistency of Skinner Box Activity Measures in the domestic Rabbit (Oryctolagus cuniculus)

Consistency of individual differences in several measures of Skinner box operant and other activity and their intercorrelations in 14 chinchilla bred rabbits were studied. Reliability analysis revealed that both operant and activity measures were highly consistent (Cronbach alpha>0.87) over at least 15 days. Furthermore, locomotor activity, the tendencies to press the lever with high frequency, to make many errors, to check the presence of food in the dispenser as well as rearing were highly inter-correlated, making up a single dimension of activity. However, grooming did not correlate with these behaviors

Consistency of Skinner Box Activity Measures in the Domestic Rabbit (Oryctolagus Cuniculus)

Consistency of individual differences in several measures of Skinner box operant and other activity and their intercorrelations in 14 chinchilla bred rabbits were studied. Reliability analysis revealed that both operant and activity measures were highly consistent (Cronbach alpha>0.87) over at least 15 days. Furthermore, locomotor activity, the tendencies to press the lever with high frequency, to make many errors, to check the presence of food in the dispenser as well as rearing were highly intercorrelated, making up a single dimension of activity. However, grooming did not correlate with these behaviors

Photon counting, censor corrections, and lifetime imaging for improved detection in two-photon microscopy

We present a high-speed photon counter for use with two-photon microscopy. Counting pulses of photocurrent, as opposed to analog integration, maximizes the signal-to-noise ratio so long as the uncertainty in the count does not exceed the gain-noise of the photodetector. Our system extends this improvement through an estimate of the count that corrects for the censored period after detection of an emission event. The same system can be rapidly reconfigured in software for fluorescence lifetime imaging, which we illustrate by distinguishing between two spectrally similar fluorophores in an in vivo model of microstroke