Microwaves in Soil Remediation from VOC’s. 1. Heat and Mass Transfer Aspects.

A novel technique presented performs in situ remediation of soils contaminated by volatile organic compounds (VOCs) based on the use of electromagnetic fields for heating operations. Attention is focused on heat and mass transfer occurring in porousmoisturized media like a soil matrix. The microwave induced steam distillation process is investigated. Measurements are reported of temperature, humidity, residual contaminant concentration, and permittivity during the process. The crucial role is elucidated that the changes of the dielectrical properties of the soil matrix play on the electromagnetic field propagation. A mathematical model of the remediation process relating all the parameters above is proposed and validated. doi: 10.1002/aic.69049072

Impact of SARS-CoV-2 (COVID-19) pandemic on patients with lysosomal storage disorders and restoration of services: experience from a specialist centre

This study aims to evaluate the impact of the COVID-19 pandemic on the lysosomal disorders unit (LSDU) at Royal Free London NHS Foundation Trust (RFL), a highly specialised national service for diagnosis and management of adults with lysosomal storage disorders (LSD). Review of home care enzyme replacement therapy (ERT) and emergency care, and COVID-19 shielding categories as per UK government guidance. New clinical pathways were developed to manage patients safely during the pandemic; staff well-being initiatives are described. LSDU staff were redeployed and/or had additional roles to support increased needs of hospitalised COVID-19 patients. During the first lockdown in March 2020, 286 of 602 LSD patients were shielding; 72 of 221 had home care ERT infusions interrupted up to 12 weeks. During the pandemic, there was a 3% reduction in home care nursing support required, with patients learning to self-cannulate or require support for cannulation only. There were no increased adverse clinical events during this period. Twenty-one contracted COVID-19 infection, with one hospitalised and no COVID-19 related deaths. In 2020, virtual clinics were increased by 88% (video and/or telephone) compared to 2019. RFL well-being initiatives supported all staff. We provide an overview of the impact of the COVID-19 pandemic on staff and patients attending a highly specialised rare disease service. As far as we are aware, this is the first detailed narrative on the challenges and subsequent rapid adaptations made, both as part of a large organisation and as a specialist centre. Lessons learnt could be translated to other rare disease services and ensure readiness for any future pandemic

Artificial Intelligence in the Water–Energy–Food Model: A Holistic Approach towards Sustainable Development Goals

This study aims to analyze the role of artificial intelligence (AI) in the Water–Energy–Food (WEF) nexus under the lens of institutional, stakeholder, and innovation theories. Specifically, this study focuses on AI as the technology adopted by companies to promote Sustainable Development Goals (SDGs). A structured literature review has been conducted on 94 articles published from 1990 to 2021 in ISI Web of Science, Scopus, and Google Scholar. This study develops an in-depth review of the literature on the main articles arguing about these issues. The findings highlight the increasing relevance of AI in the water, energy, and food industries individually considered, but the study of AI as a connector between water, energy, and food to achieve SDGs is still under investigation. Research on AI for WEF nexus management has adopted mostly a technical perspective, neglecting the relevance of management tools and the business model concept. Most of the articles did not adopt a specific theoretical lens, but scholars recognize the need to adopt a multi-stakeholder approach and the important role played by AI and other digital technologies to address the WEF nexus challenge. This study proposes an integrated approach for managing the nexus through AI technologies to meet sustainable and responsible business models. The gap between research and policy making could be filled by combining scientific data and policy needs with inclusive tools that are technically viable for sustainable resource utilization

Selective leaching of precious metals from electrical and electronic equipment through hydrometallurgical methods

The rapid human evolution has improved the quality of our lives through the use of technology. This not only resulted in increased raw materials extraction but also in the production of a worrying amount of electronic wastes. Indeed, in 2019 worldwide production of Electronic and Electric Equipment Waste (WEEE) was worth 50 million tons, causing several disadvantages such as the reduced space in landfills and massive shipping to countries with less restrictive regulations. On the other side, the billionaire electrical devices market is causing a significant increase in Precious Metals (PM) demand. Nowadays, the economic importance of PMs is as high as their supply risk. The answer to this problem consists of finding selective methods to extract and raffinate precious metals from disposed WEEE. On average, WEEEs contain around 30 % of plastics, 30 % ceramics, and 40 % metals; among these only around 0.1 % is characterized by PMs, such as gold, silver, rhodium, platinum, and palladium. The separation of PMs from other non-precious components is generally obtained using pyrometallurgy, which consists of fusing the wastes at temperatures up to 1500 ÷ 1700 °C. However, this method produces toxic gaseous byproducts and implies high energy costs. A possible alternative is given by hydrometallurgical processes, consisting of leaching the WEEE with solutions containing acids and oxidants at temperatures lower than 100°C. One of the main issues of the hydrometallurgical process is to leach copper and other non-precious base-metals selectively while keeping PMs in the solid-state. In this work, we report preliminary results of equilibrium and kinetic leaching tests in a well-stirred batch reactor, aimed at the optimization of the main operating parameters of a hydrometallurgical process for selective leaching of copper and other base-metals from Wasted Printed Circuit Boards (WPCBs). In particular, experiments have been carried out at different HCl and NaCl concentrations of the leaching solutions, exploring also the effect of temperature variation (20, 50, and 70 °C)

Peaceful coexistence: agile developer perspectives on software architecture.

This study aims to explore the relationship between agility and architecture by surveying 72 software developers at IBM. Results suggest that software architecture and agility are not like oil and water. In particular, Agile developers perceived architectures as important and supportive (rather than in contrast or neutral) to agile values. This kind of positive perception of software architectural principles and practice bodes well for future efforts to integrate agile and architecture practices

Nonlinear Projection-Based Approach for Generating Compact Models of Nonlinear Thermal Networks

A nonlinear projection-base approach for generating compact models of nonlinear thermal networks is proposed. This approach is an extension of Galerkin's method, based on the theory of kernels. High accuracy for large temperature variations and high compactness of the generated models can be obtained

Canonical Forms of Multi-Port Dynamic Thermal Networks

In this paper it is shown that multi-port dynamic thermal networks admit four canonical representations which generalize the four canonical representations of passive lumped RC networks : Foster I and II canonical forms, Cauer I and Cauer II canonical forms. In particular the generalized Foster I canonical form is equivalent to the time-constant representation and the generalized Cauer I canonical form is a passive multi-conductor RC transmission line

Stem-like and highly invasive prostate cancer cells expressing CD44v8-10 marker originate from CD44-negative cells

In human prostate cancer (PCa), the neuroendocrine cells, expressing the prostate cancer stem cell (CSC) marker CD44, may be resistant to androgen ablation and promote tumor recurrence. During the study of heterogeneity of the highly aggressive neuroendocrine PCa cell lines PC3 and DU-145, we isolated and expanded in vitro a minor subpopulation of very small cells lacking CD44 (CD44neg). Unexpectedly, these sorted CD44neg cells rapidly and spontaneously converted to a stable CD44high phenotype specifically expressing the CD44v8-10 isoform which the sorted CD44high subpopulation failed to express. Surprisingly and potentially interesting, in these cells expression of CD44v8-10 was found to be induced in stem cell medium. CD44 variant isoforms are known to be more expressed in CSC and metastatic cells than CD44 standard isoform. In agreement, functional analysis of the two sorted and cultured subpopulations has shown that the CD44v8-10pos PC3 cells, resulting from the conversion of the CD44neg subpopulation, were more invasive in vitro and had a higher clonogenic potential than the sorted CD44high cells, in that they produced mainly holoclones, known to be enriched in stem-like cells. Of interest, the CD44v8-10 is more expressed in human PCa biopsies than in normal gland. The discovery of CD44v8-10pos cells with stem-like and invasive features, derived from a minoritarian CD44neg cell population in PCa, alerts on the high plasticity of stem-like markers and urges for prudency on the approaches to targeting the putative CSC