Monoamine Oxidase A Gene Promoter Methylation And Transcriptional Downregulation in an Offender Population with Antisocial Personality Disorder

BACKGROUND: Antisocial personality disorder (ASPD) is characterised by elevated impulsive aggression and increased risk for criminal behaviour and incarceration. Deficient activity of the monoamine oxidase A (MAOA) gene is suggested to contribute to serotonergic system dysregulation strongly associated with impulsive aggression and antisocial criminality. AIMS: To elucidate the role of epigenetic processes in altered MAOA expression and serotonin regulation in a population of incarcerated offenders with ASPD compared with a healthy non-incarcerated control population. METHOD: Participants were 86 incarcerated participants with ASPD and 73 healthy controls. MAOA promoter methylation was compared between case and control groups. We explored the functional impact of MAOA promoter methylation on gene expression in vitro and blood 5-HT levels in a subset of the case group. RESULTS: Results suggest that MAOA promoter hypermethylation is associated with ASPD and may contribute to downregulation of MAOA gene expression, as indicated by functional assays in vitro, and regression analysis with whole-blood serotonin levels in offenders with ASPD. CONCLUSIONS: These results are consistent with prior literature suggesting MAOA and serotonergic dysregulation in antisocial populations. Our results offer the first evidence suggesting epigenetic mechanisms may contribute to MAOA dysregulation in antisocial offenders. Royal College of Psychiatrists

Restructuring regulation: technological convergence and European telecommunications and broadcasting markets

This article looks at the European Union (EU) policy of technological 'convergence', concentrating on the convergence of telecommunications and broadcasting. The underlying theme is that regulatory agencies are political actors and their actions need to be analysed in the context of who benefits from the policy outcome. In addition, regulatory regimes are themselves variables in bureaucratic/institutional turf wars and in the political process. The specific case discussed here of DG XIII of the European Commission responsible for telecommunications provides an example of attempts by a regulatory agency to broaden the scope of its regulatory reach. It shows how it utilized a theoretical reconstruction of markets to justify alterations both at EU and at national level in regulatory regimes that would have had direct consequences in benefiting its allied telecommunications and Internet operators and in disadvantaging public service broadcasters. The article discusses the ensuing reactions to this intervention. It concludes that DG XIII's attempts to redefine markets and regulatory regimes in its own interests and in the interests of its traditional industrial allies have not only been thwarted, but have strengthened the sectoral-based regulatory regime it wished to displace, and have also undermined its own credibility as a regulator