Mobile Daily Centre (Mdc) for Elder People with Cognitive Impairment: a Retrospective Observational Study

Introduction Trieste is a city characterized by a high mean age of the resident population, with 6,000 people with a cognitive impairment. Evidences show that is necessary to have a multidisciplinary approach, making alliances with the social network and families, while dealing with people with cognitive impairment. Because of this, the 3rd catchment district has developed a Mobile Daily Centre that aims to promote health, abilities and socialization giving the possibilities for these people to stay in a social context. Objectives Evaluating the impact of the Mobile Daily Centre on QoL of people with Cognitive Impairment. Aims Considering the rate of hospitalization and access to the first aid unit at the general hospital. Methods Retrospective Observational Study for the period between 01.01.2012 and 30.04.2014 on people in charge to the MDC. We have considered socio-demographic variables such as age, gender, care-givers; clinical variables such as psychopharmacotherapy and acetylcolinesterase-inhibitors drugs; rates of hospitalization, number of accesses to the first aid unit and of interventions of the MDC. Results in the period of the study 20 patients have been followed by the MDC; half of them had a psycho-pharmacological prescription. Very low rates of institutionalization have been detected. Conclusions MDC, in these small numbers, has shown to reduce the number of improper institutionalizations while guaranteeing to the elder people to maintain their abilities and socialization and to their care-givers periods of relief. Moreover, it promotes social inclusion and destigmatization. These results suggest that more territorial work and further studies should be done

Application of Ferroelectric Cathodes to Enhance the Ion Yield in the Caesar Source at LNS

With increasing RF power the electron concentration in the plasma of ECR ion sources is decreasing in comparison to the ion concentration, so that the plasma is charging up positively. Direct injection of electrons into the ECR plasma can increase the electron charge density and the ion current yield. We have used ferroelectric cathodes to inject electrons into the Argon plasma of the CAESAR ion source at INFN-LNS (Catania, Italy). The cathode was placed at about 10 cm from the hot plasma and a bipolar high voltage pulse of 1.6 kV was used to trigger the electron emission. No additional acceleration has been provided. The use of the ferroelectric cathode leads to an increase of about 30% of the Ar8+ intensity, which has been monitored during the test. In addition, magneto-hydrodynamic instabilities in the ECR source were damped during and after electron injection

The IsoDAR high intensity H2+ transport and injection tests

This technical report reviews the tests performed at the Best Cyclotron Systems, Inc. facility in regards to developing a cost effective ion source, beam line transport system, and acceleration system capable of high H[subscript 2][superscript +] current output for the IsoDAR (Isotope Decay At Rest) experiment. We begin by outlining the requirements for the IsoDAR experiment then provide overviews of the Versatile Ion Source (VIS), Low Energy Beam Transport (LEBT) system, spiral inflector, and cyclotron. The experimental measurements are then discussed and the results are compared with a thorough set of simulation studies. Of particular importance we note that the VIS proved to be a reliable ion source capable of generating a large amount of H[subscript 2][superscript +] current. The results suggest that with further upgrades, the VIS could potentially be a suitable candidate for IsoDAR. The conclusion outlines the key results from our tests and introduces the forthcoming work this technical report has motivated.National Science Foundation (U.S.) (PHY-1148134)Massachusetts Institute of Technology (Seed Fund)Massachusetts Institute of Technology (Bose Fellowship

Production of intense highly charged ion beams with SERSE

The source SERSE is operational at LNS since June 1998 and many improvements have been carried out in this period. The frequency has been increased from 14.5 GHz to 18 GHz and the use of two frequency heating has given positive results. Metallic ion production has been tested by means of a high temperature oven and the preliminary results are described. Tests of magnetic field scaling and frequency scaling have confirmed the results of previous tests with SC-ECRIS at lower frequency and seems to suggest that the upgrading of the source to higher frequency may be considered

Comparison between off-resonance and electron Bernstein waves heating regime in a microwave discharge ion sourcea)

A microwave discharge ion source (MDIS) operating at the Laboratori Nazionali del Sud of INFN, Catania has been used to compare the traditional electron cyclotron resonance (ECR) heating with an innovative mechanisms of plasma ignition based on the electrostatic Bernstein waves (EBW). EBW are obtained via the inner plasma electromagnetic-to-electrostatic wave conversion and they are absorbed by the plasma at cyclotron resonance harmonics. The heating of plasma by means of EBW at particular frequencies enabled us to reach densities much larger than the cutoff ones. Evidences of EBW generation and absorption together with X-ray emissions due to high energy electrons will be shown. A characterization of the discharge heating process in MDISs as a generalization of the ECR heating mechanism by means of ray tracing will be shown in order to highlight the fundamental physical differences between ECR and EBW heating

Presynaptic Homeostasis Opposes Disease Progression in Mouse Models of ALS-Like Degeneration: Evidence for Homeostatic Neuroprotection

Progressive synapse loss is an inevitable and insidious part of age-related neurodegenerative disease. Typically, synapse loss precedes symptoms of cognitive and motor decline. This suggests the existence of compensatory mechanisms that can temporarily counteract the effects of ongoing neurodegeneration. Here, we demonstrate that presynaptic homeostatic plasticity (PHP) is induced at degenerating neuromuscular junctions, mediated by an evolutionarily conserved activity of presynaptic ENaC channels in both Drosophila and mouse. To assess the consequence of eliminating PHP in a mouse model of ALS-like degeneration, we generated a motoneuron-specific deletion of Scnn1a, encoding the ENaC channel alpha subunit. We show that Scnn1a is essential for PHP without adversely affecting baseline neural function or lifespan. However, Scnn1a knockout in a degeneration-causing mutant background accelerated motoneuron loss and disease progression to twice the rate observed in littermate controls with intact PHP. We propose a model of neuroprotective homeostatic plasticity, extending organismal lifespan and health span

The Flexible Plasma Trap (FPT) for the production of overdense plasmas

Electron Cyclotron Resonance Ion Sources are currently the most efficient ionsources among those used in facilities dedicated to nuclear physics. The needfor a more flexible magnetic field and RF injection system suggested to designand develop a different type of plasma trap, named Flexible Plasma Trap (FPT).The magnetic field of FPT is generated by means of three coils while microwavesin the range 4-7 GHz can be injected by three different inputs, one placedalong the axis and two placed radially. FPT can work in different plasmaheating schemes so it will be an ideal tool for studies of plasma andmultidisciplinary physics. Moreover, a microwave launcher has been designed andinstalled to the FPT for launching microwaves with a variable tilt angle withrespect to the magnetic field. This paper describes the characteristics of theFPT along with the preliminary results of plasma diagnostics

Status of the light ion source developments at CEA/Saclay

ACC NIMInternational audienceSILHI (High Intensity Light Ion Source) is an ECR ion source producing high intensity proton ordeuteron beams at 95 keV. It is now installed in the IPHI site building, on the CEA/Saclay center. IPHI is a frontend demonstrator of high power accelerator. The source regularly delivers more than 130 mA protons in CWmode and already produced more than 170 mA deuterons in pulsed mode at nominal energy. The last beamcharacterisations, including emittance measurements, space charge compensation analysis and diagnosticimprovements, will be reported. Taking into account the SILHI experience, new developments are in progress tobuild and test a 5 mA deuteron source working in CW mode. This new source will also operate at 2.45 GHz andpermanent magnets will provide the magnetic configuration. This source, of which the design will be discussed,will have to fit in with the SPIRAL 2 accelerator developed at GANIL to produce Radioactive Ion Beams. TheH- test stand status is briefly presented here and detailed in companion papers.This work is partly supported by the European Commission under contract n°: HPRI-CT-2001-50021