547 research outputs found
Determination of synaptic phenotype: insulin and cAMP independently initiate development of electrotonic coupling between cultured sympathetic neurons.
cAMP increases junctional conductance and stimulates phosphorylation of the 27-kDa principal gap junction polypeptide.
Assessment of changes in ecosystem service delivery:a historical perspective on catchment landscapes
Although the relationships between habitats and ecosystem services (ESs) have been acknowledged, investigating spatio-temporal change in these has received far less attention. This study assesses the influence of habitat changes on ES delivery across space and time, based on two time points some 60Â years apart, 1946 and 2009. A 1946 aerial photo coverage of two catchments in Scotland was used to construct digital photo mosaics which were then visually interpreted and digitised to derive historic habitat maps. Using the Spatial Evidence for Natural Capital Evaluation (SENCE) mapping approach, the derived habitat maps were translated into ES maps. These were then compared with contemporary ES maps of the two catchments, using the same mapping methodology. Increases in provisioning ESs were associated with increases in intensively managed habitats, with reductions in supply capacity of other regulating and supporting ESs associated with loss of semi-natural habitats. ES delivery was affected not only by gross area changes in habitats over time, but also by changes in configuration and spatial distribution of constituent habitats, including fragmentation and connectivity. It is argued that understanding historic changes in ESs adds an important strand in providing baselines to inform options for current and future management of catchments
Molecular characterization and functional expression of the human cardiac gap junction channel.
Substituted benzyl acetates: a new class of compounds that reduce gap junctional conductance by cytoplasmic acidification
Conductance of gap junctions in many preparations has been shown to be sensitive to cytoplasmic pH, decreasing as pH decreases below 7.5 in fish and amphibian embryos and below 7.1 in crayfish septate axon. We have found a new class of compounds, benzyl acetate derivatives, that reversibly decrease junctional conductance, gj, when applied in low concentration (approximately 1 mM). Simultaneous intracellular pH (pHi) measurements show that the ester effects are attributable to reduction in pHi. The sensitivity of gj to these compounds and the relative lack of side effects make these agents attractive for studies of the role played by gap junctions in normal tissue function. In addition, the finding of cytoplasmic acidification in response to cell exposure to esters suggests caution in interpretation of results obtained using esterified compounds for intracellular loading
Perfectionism and achievement goals in young Finnish ice-hockey players aspiring to make the Under-16 national team
Research on perfectionism suggests that is it useful to differentiate between perfectionistic strivings and perfectionistic concerns. Regarding the 2 x 2 achievement goal framework, the usefulness of this differentiation was recently demonstrated in a study with university student athletes (Stoeber, Stoll, Pescheck, & Otto, 2008, Study 2), in which it was found that perfectionistic strivings were associated with mastery-approach and performance-approach goals and perfectionistic concerns with mastery-avoidance, performance-approach, and performance-avoidance goals. Because the study was largely exploratory and only used non-elite athletes, the aim of the present research was to replicate and extend these findings by investigating a sample of 138 young, elite ice-hockey players, while adding further measures of perfectionism and using structural equation modelling (SEM) to confirm the relationships between perfectionistic strivings, perfectionistic concerns,and the 2 x 2 achievement goals. The SEM results showed that, in elite athletes also, perfectionistic strivings are associated with mastery-approach and performance-approach goals, whereas perfectionistic concerns are associated with masteryavoidance,
performance-approach, and performance-avoidance goals. Our findings corroborate the importance of differentiating between perfectionistic strivings and perfectionistic concerns when studying perfectionism in sports, because
only perfectionistic concerns (and not perfectionistic strivings) are associated with maladaptive patterns of achievement goals
OECD principles on water governance in practice:an assessment of existing frameworks in Europe, Asia-Pacific, Africa and South America
Through the lens of the 12 OECD Principles on Water Governance, this article examines six water resources and water services frameworks in Europe, Asia-Pacific, Africa and South America to understand enhancing and constraining contextual factors. Qualitative and quantitative methods are used to analyze each framework against four criteria: alignment; implementation; on-ground results; and policy impact. Four main target areas are identified for improving water governance: policy coherence; financing; managing trade-offs; and ensuring integrity and transparency by all decision makers and stakeholders. Suggestions are presented to support practical implementation of the principles through better government action and stakeholder involvement.No Full Tex
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