Investigating the transfer of toughness from rubber modified bulk epoxy polymers to syntactic foams

Syntactic foams are lightweight, high specific strength materials used in the aerospace and naval 10 industries. Their utility is limited by their brittleness. The epoxy polymer matrix in an epoxy/hollow 11 glass microsphere (GMS) syntactic foam was modified using carboxyl-terminated butadiene-acrylonitrile 12 (CTBN) rubber with the aim to increase fracture toughness. The microstructure and fracture properties 13 were investigated, and compared to CTBN modified bulk epoxy polymers. The formation of complex CTBN microstructures was responsible for the increase in fracture energy, from 193 J/m2 14 for the unmodified syntactic foam, to 296 J/m2 15 at 12 wt% CTBN modification. However, this increase is much smaller than for the CTBN modification of bulk epoxy polymers, where an increase from 101 J/m2 16 to 1112 J/m2 17 was measured for the same CTBN concentration. There is little toughness transfer from the 18 bulk epoxy polymers to the syntactic foams, attributable to small interstitial regions between the GMS, 19 restricting plastic zone size. A statistical approach to the analytical modelling of fracture energy in the 20 bulk epoxy polymers highlights the importance of considering the underlying distribution of rubber 21 particle and void sizes. The increase in fracture energy achieved in this work can increase the overall 22 usefulness of syntactic foams in structural applications

Functional Imaging of the Outer Retinal Complex using High Fidelity Imaging Retinal Densitometry

We describe a new technique, high fidelity Imaging Retinal Densitometry (IRD), which probes the functional integrity of the outer retinal complex. We demonstrate the ability of the technique to map visual pigment optical density and synthesis rates in eyes with and without macular disease. A multispectral retinal imaging device obtained precise measurements of retinal reflectance over space and time. Data obtained from healthy controls and 5 patients with intermediate AMD, before and after photopigment bleaching, were used to quantify visual pigment metrics. Heat maps were plotted to summarise the topography of rod and cone pigment kinetics and descriptive statistics conducted to highlight differences between those with and without AMD. Rod and cone visual pigment synthesis rates in those with AMD (v = 0.043 SD 0.019 min-1 and v = 0.119 SD 0.046 min-1, respectively) were approximately half those observed in healthy controls (v = 0.079 SD 0.024 min-1 for rods and v = 0.206 SD 0.069 min-1 for cones). By mapping visual pigment kinetics across the central retina, high fidelity IRD provides a unique insight into outer retinal complex function. This new technique will improve the phenotypic characterisation, diagnosis and treatment monitoring of various ocular pathologies, including AMD

HIV Pre-Exposure Prophylaxis (PrEP)—A Quantitative Ethics Appraisal

Background: There is now strong evidence that preventive oral antiretroviral therapy can moderately reduce likelihood of HIV infection. This concept is called HIV pre-exposure prophylaxis (PrEP). Premature closures of some previous PrEP clinical trials, secondary to ethical concerns, did not stop research. We aimed to appraise the extent of ethics considerations reporting in PrEP study documents. Methods: We conducted a systematic quantitative ethics appraisal, grounded in PrEP literature and using eight principles proposed by Ezechiel Emanuel. We developed an a priori checklist of 101 evidence-based ethics items. We obtained protocols for eleven of nineteen clinical controlled studies identified. Two reviewers independently appraised study documents against the checklist. Ethics appraisal was synthesized using adjusted percentages of items reported. Results: On average, 58 % of the 101 ethics items were mentioned or addressed in documents, with variations noted both across studies and across principles. Considerations pertaining to social value were least reported (43 % of checklist items, on average) whereas considerations related to informed consent and favorable risk-benefit ratio were most reported (75 % of checklist items, on average). Discussion: Some PrEP studies reportedly address more ethics considerations than others but, overall, ethics considerations reporting could be much improved. While this review does not allow us to comment on the actual execution of HIV PrE

The CMB Bispectrum

We use a separable mode expansion estimator with WMAP data to estimate the bispectrum for all the primary families of non-Gaussian models. We review the late-time mode expansion estimator methodology which can be applied to any non-separable primordial and CMB bispectrum model, and we demonstrate how the method can be used to reconstruct the CMB bispectrum from an observational map. We extend the previous validation of the general estimator using local map simulations. We apply the estimator to the coadded WMAP 5-year data, reconstructing the WMAP bispectrum using $l<500$ multipoles and $n=31$ orthonormal 3D eigenmodes. We constrain all popular nearly scale-invariant models, ensuring that the theoretical bispectrum is well-described by a convergent mode expansion. Constraints from the local model \fnl=54.4\pm 29.4 and the equilateral model \fnl=143.5\pm 151.2 (\Fnl = 25.1\pm 26.4) are consistent with previously published results. (Here, we use a nonlinearity parameter \Fnl normalised to the local case, to allow more direct comparison between different models.) Notable new constraints from our method include those for the constant model \Fnl = 35.1 \pm 27.4 , the flattened model \Fnl = 35.4\pm 29.2, and warm inflation \Fnl = 10.3\pm 27.2. We investigate feature models surveying a wide parameter range in both the scale and phase, and we find no significant evidence of non-Gaussianity in the models surveyed. We propose a measure \barFnl for the total integrated bispectrum and find that the measured value is consistent with the null hypothesis that CMB anisotropies obey Gaussian statistics. We argue that this general bispectrum survey with the WMAP data represents the best evidence for Gaussianity to date and we discuss future prospects, notably from the Planck satellite

Platelet-rich plasmapheresis in cardiac surgery: A meta-analysis of the effect on transfusion requirements

AbstractObjective:Our purpose was to determine whether intraoperative platelet-rich plasmapheresis in cardiac surgery is effective in reducing the proportion of patients exposed to allogeneic red cell transfusions. Methods: A systematic search for prospective, randomized trials of platelet-rich plasmapheresis in cardiac surgery, using MEDLINE, HEALTHSTAR, Current Contents, “Biological Abstracts,” and EMBASE/Excerpta Medica up to August 1997, was completed. Trials were included if they reported either the proportion of patients exposed to allogeneic red cells or the units of allogeneic red cells transfused. Trials were abstracted by 2 independent investigators and the quality of trial design was assessed with the use of a validated scale. Results: Seventeen references met the inclusion criteria (1369 patients [675 control: 694 platelet-rich plasmapheresis]). Platelet-rich plasmapheresis reduced the likelihood of exposure to allogeneic red cells in cardiac surgery (odds ratio 0.44; 95% confidence interval 0.27, 0.72, P = .001). Platelet-rich plasmapheresis had a small but statistically significant effect on both the volume of blood lost in the first 24 hours (weighted mean difference –102 mL; 95% confidence interval –148, –55 mL, P < .0001) and the mean units transfused (weighted mean difference –0.33 units; 95% confidence interval –0.43, –0.23, P < .0001). However, platelet-rich plasmapheresis was only marginally effective (odds ratio 0.83, 95% confidence interval 0.34, 2.01, P = .68) for “good” quality trials, whereas it appeared very effective in trials with poor methodologic quality (odds ratio 0.33, 95% confidence interval 0.17, 0.62, P = .0007). Conclusions: Although platelet-rich plasmapheresis appeared effective in decreasing the proportion of patients receiving transfusions after cardiac operations, the quality of most of the supporting trials was low and the benefit was small in trials of good quality. Further clinical trials should be completed. (J Thorac Cardiovasc Surg 1998;116:641-7

Oscillations in the bispectrum

There exist several models of inflation that produce primordial bispectra that contain a large number of oscillations. In this paper we discuss these models, and aim at finding a method of detecting such bispectra in the data. We explain how the recently proposed method of mode expansion of bispectra might be able to reconstruct these spectra from separable basis functions. Extracting these basis functions from the data might then lead to observational constraints on these models.Comment: 6 pages, 2 figures, submitted to JOP: Conference Series, PASCOS 201

The characteristics of sexual abuse in sport: A multidimensional scaling analysis of events described in media reports

Most research on sexual abuse has been conducted within family settings (Fergusson & Mullen, 1999). In recent years, following several high profile convictions and scandals, research into sexual abuse has also encompassed institutional and community settings such as sport and the church (Gallagher, 2000; Wolfe et al., 2003). Research into sexual abuse in sport, for example, began with both prevalence studies (Kirby & Greaves, 1996; Leahy, Pretty & Tenenbaum, 2002) and qualitative analyses of the processes and experiences of athlete sexual abuse (Brackenridge, 1997; Cense & Brackenridge, 2001, Toftegaard Nielsen, 2001). From such work, descriptions of the modus operandi of abusers in sport, and the experiences and consequences for athlete victims, have been provided, informing both abuse prevention work and coach education. To date, however, no study has provided empirical support for multiple associations or identified patterns of sex offending in sport in ways that might allow comparisons with research-generated models of offending outside sport. This paper reports on an analysis of 159 cases of criminally defined sexual abuse, reported in the print media over a period of 15 years. The main aim of the study was to identify the nature of sex offending in sport focusing on the methods and locations of offences. The data were analysed using multidimensional scaling (MDS), as a data reduction method, in order to identify the underlying themes within the abuse and explore the inter-relationships of behaviour, victim and context variables. The findings indicate that there are specific themes that can be identified within the perpetrator strategies that include ‘intimate’, ‘aggressive’, and ‘’dominant’ modes of interaction. The same patterns that are described here within the specific context of sport are consistent with themes that emerge from similar behavioural analyses of rapists (Canter & Heritage, 1990; Bishopp, 2003) and child molester groups (Canter, Hughes & Kirby, 1998). These patterns show a correspondence to a broader behavioural model – the interpersonal circumplex (e.g., Leary 1957). Implications for accreditation and continuing professional education of sport psychologists are noted

Toughening epoxy syntactic foams with milled carbon fibres: mechanical properties and toughening mechanisms

Syntactic foams comprising hollow glass microspheres (GMS) in an epoxy matrix are critical materials for lightweight structures, being extensively used in marine and aerospace as cores for composite sandwich panels. They are buoyant and crush resistant, but their use is limited by their brittleness. Milled carbon fibres (MCF) were used to increase toughness, by introducing energy absorption mechanisms, to foams comprising ∼60 vol% GMS. Weight ratios of up to 40% MCF:GMS were used. The tensile modulus of the foams increased from 3.36 GPa to 5.41 GPa with the addition of 40% weight ratio of MCF. The tensile strength of the syntactic foam decreased with low loadings of MCF, but then recovers when more MCF particles are added, and the mechanisms responsible are explained for the first time. The fracture energy of the syntactic foam increased by 183%, from 182 J/m2 to 516 J/m2, due to the addition of 40% weight ratio of MCF. Toughening mechanisms were identified as crack deflection, debonding and subsequent plastic void growth, and fibre pull-out. Thus, the simple and cheap addition of MCF greatly increases the toughness of the syntactic foams, enabling lighter or more damage-resistant structures to be produced

Fracture performance of fibre-reinforced epoxy foam

Low density aramid and carbon fibre-reinforced epoxy foam has been synthesised with the aim of improving mechanical properties, principally fracture performance. The foam properties measured were fracture energy, compressive strength, and density. The influence of fibre type, loading, and length was investigated. In addition, composite face-sheet bond tests were performed to ascertain how effective toughness transferred from individual component to composite structure. In general, the addition of fibres improved the mechanical performance of reinforced samples compared to the control foam. Increases in compressive strength were moderate whilst fracture energy was increased by up to 107% from 124 J/m2 to 256 J/m2 by the addition of 0.75 mm aramid fibres. Increased fracture energy of the foam and the presence of fibres on the foam surface, caused an increase in face-sheet bond propagation fracture toughness of 50% from 277 J/m2 to 416 J/m2

Micromechanical modelling of syntactic foam

A combined numerical-experimental method that enables accurate prediction of not only the elastic moduli and tensile failure strengths of syntactic foams, but also accounts for the experimentally observed scatter in these measurements is presented. In general, for the systems studied, an increase in microsphere content resulted in an increase in tensile modulus and a decrease in tensile strength. At low particle loading ratios, the variance in the measured experimental strength can be almost entirely attributed to the distribution of inter-particle distances between the microspheres, whilst at high particle loadings, geometric variance in the microstructure is shown to be only partially responsible for the observed scatter in strength data. Thus, for the first time, a direct link between the underlying microstructure and the experimentally observed scatter in fracture strength is drawn and substantiated with modelling