Using the nonhuman primate model of HCMV to guide vaccine development.

The natural history of human cytomegalovirus (HCMV) is inextricably associated with mucosal surfaces. The vast preponderance of primary infections occur following mucosal exposure to infectious virions, and the high seroprevalence of HCMV throughout the world is due to long-term excretion of HCMV in bodily fluids from multiple mucosal sites. Accumulating evidence presents a model where the earliest virus-host interactions following infection dictate the long-term pattern of infection, alter innate immune responses that skew adaptive responses to enable persistence within an immune host, and are essential for reinfection of a host with prior immunity. HCMV has evolved a complex repertoire of viral functions fine-tuned to manipulate the immune environment both locally at the sites of infection and systemically within an infected host. Collectively, viral immune modulation represents a significant impediment for an HCMV vaccine. As HCMV can disseminate beyond mucosal surfaces to reinfect immune hosts, it may not matter whether prior immunity results from prior infection or immunization. A better understanding of the earliest virus-hosts interactions at mucosal surfaces may identify elements of the viral proteome that are especially susceptible to vaccine-mediated disruption and prevent challenge virus from disseminating to distal sites, particularly the maternal-fetal interface

Ozone model for bonding of an O_2 to heme in oxyhemoglobin

Several rather different models of the Fe-O_2 bond in oxyhemoglobin have previously been proposed, none of which provide a satisfactory explanation of several properties. We propose a new model for the bonding of an O_2 to the Fe of myoglobin and hemoglobin and report ab initio generalized valence bond and configuration interaction calculations on FeO_2 that corroborate this model. Our model is based closely upon the bonding in ozone which recent theoretical studies have shown to be basically a biradical with a singlet state stabilized by a three-center four-electron pi bond. In this model, the facile formation and dissociation of the Fe-O_2 bond is easily rationalized since the O_2 always retains its triplet ground state character. The ozone model leads naturally to a large negative electric field gradient (in agreement with Mossbauer studies) and to z-polarized (perpendicular to the heme) charge transfer transitions. It also suggests that the 1.3 eV transition, present in HbO_2 and absent in HbCO, is due to a porphyrin-to-Fe transition, analogous to that of ferric hemoglobins (e.g., HbCN)

Employee Compensation and Advanced Manufacturing Technology

[Excerpt] The globalization of product markets has intensified competition in an increasingly wide array of industries, including automobiles, consumer electronics,steel, and computer chips to name just a few. In manufacturing as a whole during the last thirty years, productivity growth in the U.S. has lagged significantly behind that of Japan, Germany, Sweden, and many other industrialized countries. For example, between 1960 and 1985, the annual growth in manufacturing productivity (output per hour) was 2.7 percent in the U.S. compared with 8.0 percent in Japan. Unless this trend can be turned around, U.S. companies will find it increasingly difficult to compete in the world market

U.S. East Coast Trough Indices at 500 hPa and New England Winter Climate Variability

Using monthly gridded 500-hPa data, two synoptic indices are defined to better understand the principle mechanisms controlling intraseasonal to multiannual winter climate variability in NewEngland (NE). The “trough axis index” (TAI) is created to quantify the mean longitudinal position of the common East Coast pressure trough, and the “trough intensity index” (TII) is calculated to estimate the relative amplitude of this trough at 42.5°N. The TAI and TII are then compared with records for NE regional winter precipitation, temperature, and snowfall with the goal of understanding physical mechanisms linking NE winter climate with regional sea surface temperatures (SST), the North Atlantic Oscillation (NAO), and the Pacific–North American (PNA) teleconnection pattern. The TAI correlates most significantly with winter precipitation at inland sites, such that a western (eastern)trough axis position is associated with greater (lower) average monthly precipitation. Also, significant correlations between the TAI and both NE regional SSTs and the NAO suggest that longitudinal shifting of the trough is one possible mechanism linking the North Atlantic with NE regional winterclimate variability. The NE winter temperature is significantly correlated with the TII, regional SSTs, and the NAO. While the PNA also correlates with the TII, NE winter climate variables are apparently unrelated to the PNA index

Evaluation of the capture efficiency and size selectivity of four pot types in the prospective fishery for North Pacific giant octopus (Enteroctopus dofleini)

Over 230 metric tons of octopus is harvested as bycatch annually in Alaskan trawl, long-line, and pot fisheries. An expanding market has fostered interest in the development of a directed fishery for North Pacific giant octopus (Enteroctopus dofleini). To investigate the potential for fishery development we examined the efficacy of four different pot types for capture of this species. During two surveys in Kachemak Bay, Alaska, strings of 16 –20 sablefish, Korean hair crab, shrimp, and Kodiak wooden lair pots were set at depths ranging between 62 and 390 meters. Catch per-unit-of-ef for t estimates were highest for sablefish and lair pots. Sablefish pots caught significantly heavier North Pacific giant octopuses but also produced the highest bycatch of commercially important species, such as halibut (Hippoglossus stenolepis), Pacific cod (Gadus macrocephalus), and Tanner crab (Chionoecetes bairdi)

Is Globalization Today Really Different than Globalization a Hunderd Years Ago?

This paper pursues the comparison of economic integration today and pre 1914 for trade as well as finance, primarily for the United States but also with reference to the wider world. We establish the outlines of international integration a century ago and analyze the institutional and informational impediments that prevented the late nineteenth century world from achieving the same degree of integration as today. We conclude that the world today is different: commercial and financial integration before World War I was more limited. Given that integration today is even more pervasive than a hundred years ago, it is surprising that trade tensions and financial instability have not been worse in recent years. In the conclusion we point to the institutional innovations that have taken place in the past century as an explanation. This in turn suggests the way forward for national governments and multilaterals.

Leptogenesis in models with keV sterile neutrino dark matter

We analyze leptogenesis in gauge extensions of the Standard Model with keV sterile neutrino dark matter. We find that both the observed dark matter abundance and the correct baryon asymmetry of the Universe can simultaneously emerge in these models. Both the dark matter abundance and the leptogenesis are controlled by the out of equilibrium decays of the same heavy right handed neutrino.Comment: 6 pages, 1 figur

The Importance of Recruitment in Job Choice: A Different Way of Looking

Recent literature reviews have called into question the impact of recruitment activities on applicants\u27 job choices. However, most previous findings have been based on cross-sectional ratings obtained immediately after initial screening interviews, thus raising questions about the degree to which prior conclusions are bound to that particuJar methodology. In contrast, the present study used longitudinal structured interviews to let job seekers explain, in their own words, how they made critical job search and choice decisions. Interview transcripts revealed that recruitment practices played a variety of roles in job seeker decisions. For example, consistent with signalling theory, subjects interpreted a wide variety of recruitment experiences (recruiter competence, sex composition of interview panels, recruitment delays) as symbolic of broader organizational characteristics. In addition, a number of contingency variables emerged that seemed to affect the perceived signalling value of recruitment experiences (e.g., prior knowledge of the company, functional area of the recruiter). Also notable were the strongly negative effects of recruitment delays, particularly among male students with higher grade point averages and greater job search success. Finally, our results suggest that certain applicant reactions may be systematically related to sex, work experience, grade point average, and search success. The article concludes with practical and research implications

DREIDING: A generic force field for molecular simulations

We report the parameters for a new generic force field, DREIDING, that we find useful for predicting structures and dynamics of organic, biological, and main-group inorganic molecules. The philosophy in DREIDING is to use general force constants and geometry parameters based on simple hybridization considerations rather than individual force constants and geometric parameters that depend on the particular combination of atoms involved in the bond, angle, or torsion terms. Thus all bond distances are derived from atomic radii, and there is only one force constant each for bonds, angles, and inversions and only six different values for torsional barriers. Parameters are defined for all possible combinations of atoms and new atoms can be added to the force field rather simply. This paper reports the parameters for the "nonmetallic" main-group elements (B, C, N, 0, F columns for the C, Si, Ge, and Sn rows) plus H and a few metals (Na, Ca, Zn, Fe). The accuracy of the DREIDING force field is tested by comparing with (i) 76 accurately determined crystal structures of organic compounds involving H, C, N, 0, F, P, S, CI, and Br, (ii) rotational barriers of a number of molecules, and (iii) relative conformational energies and barriers of a number of molecules. We find excellent results for these systems

Recruiter Perceptions of Applicant Fit: Commonalities and Differences

To date, normative selection models have focused primarily on matching individual knowledges, skills, and abilities to job requirements. However, it has increasingly been argued that people should also be selected for fit to broader organizational characteristics such as strategy, culture and values. Despite the apparent reasonableness of these claims, there has been little research on how employers actually go about the task of screening or selecting for broader organizational fit. Accordingly, the present study examined how organizational recruiters assess applicant fit. Fifty-four campus recruiters in four colleges provided examples of best-fitting and worst-fitting applicants from just-completed interview schedules, along with specific descriptions of what it was that made each applicant fit or not fit . Examination of interview transcripts suggested that despite the recent emphasis on unique organizational values, strategies, or cultures in discussions of fit, by far the most frequently-mentioned determinants of fit were either (1) job-related coursework or experience, or (2) generally (rather than uniquely) desirable personal characteristics such as articulateness, positive personal appearance, and good general communication skills. However, some systematic differences were detected in the extent to which particular characteristics were sought by recruiters in different colleges or by those recruiting for different types of vacancies. Findings are related to previous research, and implications for applicants, employers, and future researchers are offered