Materials for phantoms for terahertz pulsed imaging

Phantoms are commonly used in medical imaging for quality assurance, calibration, research and teaching. They may include test patterns or simulations of organs, but in either case a tissue substitute medium is an important component of the phantom. The aim of this work was to identify materials suitable for use as tissue substitutes for the relatively new medical imaging modality terahertz pulsed imaging. Samples of different concentrations of the candidate materials TX151 and napthol green dye were prepared, and measurements made of the frequency-dependent absorption coefficient (0.5 to 1.5 THz) and refractive index (0.5 to 1.0 THz). These results were compared qualitatively with measurements made in a similar way on samples of excised human tissue (skin, adipose tissue and striated muscle). Both materials would be suitable for phantoms where the dominant mechanism to be simulated is absorption (similar to ∼100 cm(-1) at 1 THz) and where simulation of the strength of reflections from boundaries is not important; for example, test patterns for spatial resolution measurements. Only TX151 had a frequency-dependent refractive index close to that of tissue, and could therefore be used to simulate the layered structure of skin, the complexity of microvasculature or to investigate frequency-dependent interference effects that have been noted in terahertz images

Holographic Measurement and Improvement of the Green Bank Telescope Surface

We describe the successful design, implementation, and operation of a 12 GHz holography system installed on the Robert C. Byrd Green Bank Telescope (GBT). We have used a geostationary satellite beacon to construct high-resolution holographic images of the telescope mirror surface irregularities. These images have allowed us to infer and apply improved position offsets for the 2209 actuators which control the active surface of the primary mirror, thereby achieving a dramatic reduction in the total surface error (from 390 microns to ~240 microns, rms). We have also performed manual adjustments of the corner offsets for a few panels. The expected improvement in the radiometric aperture efficiency has been rigorously modeled and confirmed at 43 GHz and 90 GHz. The improvement in the telescope beam pattern has also been measured at 11.7 GHz with greater than 60 dB of dynamic range. Symmetric features in the beam pattern have emerged which are consistent with a repetitive pattern in the aperture due to systematic panel distortions. By computing average images for each tier of panels from the holography images, we confirm that the magnitude and direction of the panel distortions, in response to the combination of gravity and thermal gradients, are in general agreement with finite-element model predictions. The holography system is now fully integrated into the GBT control system, and by enabling the telescope staff to monitor the health of the individual actuators, it continues to be an essential tool to support high-frequency observations.Comment: Accepted for publication in PASP. Contains 28 pages with 2 tables and 9 figures (several at reduced quality). The full resolution version is available at http://wwwlocal.gb.nrao.edu/ptcs/papers/Hunter2011/gbtholo.ps.gz (34MB gzip file unpacks to 134MB postscript

Bias in mean velocities and noise in variances and covariances measured using a multistatic acoustic profiler: The Nortek Vectrino Profiler

This paper compiles the technical characteristics and operating principles of the Nortek Vectrino Profiler and reviews previously reported user experiences. A series of experiments are then presented that investigate instrument behaviour and performance, with a particular focus on variations within the profile. First, controlled tests investigate the sensitivity of acoustic amplitude (and Signal-to-Noise Ratio, SNR) and pulse-to-pulse correlation coefficient, R2, to seeding concentration and cell geometry. Second, a novel methodology that systematically shifts profiling cells through a single absolute vertical position investigates the sensitivity of mean velocities, SNR and noise to: (a). emitted sound intensity and the presence (or absence) of acoustic seeding; and (b). varying flow rates under ideal acoustic seeding conditions. A new solution is derived to quantify the noise affecting the two orthogonal tristatic systems of the Vectrino Profiler and its contribution to components of the Reynolds stress tensor. Results suggest that for the Vectrino Profiler: 1. optimum acoustic seeding concentrations are ~3,000 to 6,000 mg L-1; 2. mean velocity magnitudes are biased by variable amounts in proximal cells but are consistently underestimated in distal cells; 3. noise varies parabolically with a minimum around the "sweet spot", 50 mm below the transceiver; 4. the receiver beams only intersect at the sweet spot and diverge nearer to and further from the transceiver. This divergence significantly reduces the size of the sampled area away from the sweet spot, reducing data quality; 5. the most reliable velocity data will normally be collected in the region between approximately 43 and 61 mm below the transceiver

"Delirium Day": A nationwide point prevalence study of delirium in older hospitalized patients using an easy standardized diagnostic tool

Background: To date, delirium prevalence in adult acute hospital populations has been estimated generally from pooled findings of single-center studies and/or among specific patient populations. Furthermore, the number of participants in these studies has not exceeded a few hundred. To overcome these limitations, we have determined, in a multicenter study, the prevalence of delirium over a single day among a large population of patients admitted to acute and rehabilitation hospital wards in Italy. Methods: This is a point prevalence study (called "Delirium Day") including 1867 older patients (aged 65 years or more) across 108 acute and 12 rehabilitation wards in Italian hospitals. Delirium was assessed on the same day in all patients using the 4AT, a validated and briefly administered tool which does not require training. We also collected data regarding motoric subtypes of delirium, functional and nutritional status, dementia, comorbidity, medications, feeding tubes, peripheral venous and urinary catheters, and physical restraints. Results: The mean sample age was 82.0 \ub1 7.5 years (58 % female). Overall, 429 patients (22.9 %) had delirium. Hypoactive was the commonest subtype (132/344 patients, 38.5 %), followed by mixed, hyperactive, and nonmotoric delirium. The prevalence was highest in Neurology (28.5 %) and Geriatrics (24.7 %), lowest in Rehabilitation (14.0 %), and intermediate in Orthopedic (20.6 %) and Internal Medicine wards (21.4 %). In a multivariable logistic regression, age (odds ratio [OR] 1.03, 95 % confidence interval [CI] 1.01-1.05), Activities of Daily Living dependence (OR 1.19, 95 % CI 1.12-1.27), dementia (OR 3.25, 95 % CI 2.41-4.38), malnutrition (OR 2.01, 95 % CI 1.29-3.14), and use of antipsychotics (OR 2.03, 95 % CI 1.45-2.82), feeding tubes (OR 2.51, 95 % CI 1.11-5.66), peripheral venous catheters (OR 1.41, 95 % CI 1.06-1.87), urinary catheters (OR 1.73, 95 % CI 1.30-2.29), and physical restraints (OR 1.84, 95 % CI 1.40-2.40) were associated with delirium. Admission to Neurology wards was also associated with delirium (OR 2.00, 95 % CI 1.29-3.14), while admission to other settings was not. Conclusions: Delirium occurred in more than one out of five patients in acute and rehabilitation hospital wards. Prevalence was highest in Neurology and lowest in Rehabilitation divisions. The "Delirium Day" project might become a useful method to assess delirium across hospital settings and a benchmarking platform for future surveys