454 research outputs found

    Efficient error correction and haplotypes reconstruction for deep sequencing of hepatitis c amplicons

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    Секция 1. Защита информации и компьютерный анализ данныхWe present two new highly efficient pyrosequencing error correction algorithms: (i) k-mer – based error correction (KEC); and (ii) empirical frequency threshold (ET). Both were compared to the recently published clustering algorithm SHORAH to evaluate the relative performance using 24 experimental datasets obtained by 454-sequencing of amplicons with known sequences. We found that all three algorithms showed similar performance in terms of finding true haplotypes, but KEC and ET methods significantly outperformed SHORAH both in terms of their ability to remove false haplotypes and to estimate the frequency of true ones

    Motivational Social Visualizations for Personalized E-Learning

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    A large number of educational resources is now available on the Web to support both regular classroom learning and online learning. However, the abundance of available content produces at least two problems: how to help students find the most appropriate resources, and how to engage them into using these resources and benefiting from them. Personalized and social learning have been suggested as potential methods for addressing these problems. Our work presented in this paper attempts to combine the ideas of personalized and social learning. We introduce Progressor + , an innovative Web-based interface that helps students find the most relevant resources in a large collection of self-assessment questions and programming examples. We also present the results of a classroom study of the Progressor +  in an undergraduate class. The data revealed the motivational impact of the personalized social guidance provided by the system in the target context. The interface encouraged students to explore more educational resources and motivated them to do some work ahead of the course schedule. The increase in diversity of explored content resulted in improving students’ problem solving success. A deeper analysis of the social guidance mechanism revealed that it is based on the leading behavior of the strong students, who discovered the most relevant resources and created trails for weaker students to follow. The study results also demonstrate that students were more engaged with the system: they spent more time in working with self-assessment questions and annotated examples, attempted more questions, and achieved higher success rates in answering them

    Restoration of Overlap Functions and Spectroscopic Factors in Nuclei

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    An asymptotic restoration procedure is applied for analyzing bound--state overlap functions, separation energies and single--nucleon spectroscopic factors by means of a model one--body density matrix emerging from the Jastrow correlation method in its lowest order approximation for 16O^{16}O and 40Ca^{40}Ca nuclei . Comparison is made with available experimental data and mean--field and natural orbital representation results.Comment: 5 pages, RevTeX style, to be published in Physical Review
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