152 research outputs found
A SingleâCell Perspective of the Mammalian Liver in Health and Disease
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/154943/1/hep31149_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/154943/2/hep31149.pd
hnRNPU/TrkB Defines a Chromatin Accessibility Checkpoint for Liver Injury and Nonalcoholic Steatohepatitis Pathogenesis
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/154982/1/hep30921-sup-0001-Supinfo.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/154982/2/hep30921.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/154982/3/hep30921_am.pd
Cooperative photoinduced metastable phase control in strained manganite films
A major challenge in condensed matter physics is active control of quantum
phases. Dynamic control with pulsed electromagnetic fields can overcome
energetic barriers enabling access to transient or metastable states that are
not thermally accessible. Here we demonstrate strain-engineered tuning of
La2/3Ca1/3MnO3 into an emergent charge-ordered insulating phase with extreme
photo-susceptibility where even a single optical pulse can initiate a
transition to a long-lived metastable hidden metallic phase. Comprehensive
single-shot pulsed excitation measurements demonstrate that the transition is
cooperative and ultrafast, requiring a critical absorbed photon density to
activate local charge excitations that mediate magnetic-lattice coupling that,
in turn, stabilize the metallic phase. These results reveal that strain
engineering can tune emergent functionality towards proximal macroscopic states
to enable dynamic ultrafast optical phase switching and control
Remdesivir for 5 or 10 Days in Patients With Severe Covid-19
Background: Remdesivir is an RNA polymerase inhibitor with potent antiviral activity in vitro and efficacy in animal models of coronavirus disease 2019 (Covid-19). Methods: We conducted a randomized, open-label, phase 3 trial involving hospitalized patients with confirmed SARS-CoV-2 infection, oxygen saturation of 94% or less while they were breathing ambient air, and radiologic evidence of pneumonia. Patients were randomly assigned in a 1:1 ratio to receive intravenous remdesivir for either 5 days or 10 days. All patients received 200 mg of remdesivir on day 1 and 100 mg once daily on subsequent days. The primary end point was clinical status on day 14, assessed on a 7-point ordinal scale. Results: In total, 397 patients underwent randomization and began treatment (200 patients for 5 days and 197 for 10 days). The median duration of treatment was 5 days (interquartile range, 5 to 5) in the 5-day group and 9 days (interquartile range, 5 to 10) in the 10-day group. At baseline, patients randomly assigned to the 10-day group had significantly worse clinical status than those assigned to the 5-day group (P = 0.02). By day 14, a clinical improvement of 2 points or more on the ordinal scale occurred in 64% of patients in the 5-day group and in 54% in the 10-day group. After adjustment for baseline clinical status, patients in the 10-day group had a distribution in clinical status at day 14 that was similar to that among patients in the 5-day group (P = 0.14). The most common adverse events were nausea (9% of patients), worsening respiratory failure (8%), elevated alanine aminotransferase level (7%), and constipation (7%). Conclusions: In patients with severe Covid-19 not requiring mechanical ventilation, our trial did not show a significant difference between a 5-day course and a 10-day course of remdesivir. With no placebo control, however, the magnitude of benefit cannot be determined. (Funded by Gilead Sciences; GS-US-540-5773 ClinicalTrials.gov number, NCT04292899.)
Percutaneous Microwave Ablation in the Spleen for Treatment of Hypersplenism in Cirrhosis Patients
Association between polymorphisms in DNA repair genes and survival of non-smoking female patients with lung adenocarcinoma
Peritoneal tuberculosis presenting with portal vein thrombosis and transudative Ascites - a diagnostic dilemma: case report
Association between polymorphisms in XRCC1 gene and clinical outcomes of patients with lung cancer: a meta-analysis
Patterns of smoking and its association with psychosocial work conditions among blue-collar and service employees of hospitality venues in Shenyang, PR China
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