1,842 research outputs found

    Well-being Consciousness and College Access Borderlands: Staff Perspectives on Supporting Students’ Well-Being

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    More than 2550 pre-college preparation and college access programs in the United States are designed to increase the postsecondary enrollment and degree obtainment rates for historically excluded college students, including low-income and Students of Color. Less known is how these programs address the social emotional, and well-being needs of college-going Black and Indigenous women enrolling at Predominately White Institutions (PWIs). Guided by Gloria Anzaldúa’s Borderlands theory, this study analyzed interviews with five current and former college access program staff to uncover if and how college access programs define and implement well-being into college access initiatives. Findings revealed varied racialized and gendered conceptions and expectations of well-being, as well as competing outcome-based threats to developing a well-being consciousness. This study contributes new scholarship on the cultivation of well-being in college access spaces from the perspective of college access staff

    A VLT/VIMOS view of two PlanckPlanck multiple-cluster systems: structure and galaxy properties

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    We analysed spectroscopic data obtained with VLT-VIMOS for two multiple-cluster systems, PLCKG214.6+36.9214.6+36.9 and PLCKG334.838.0334.8-38.0, discovered via their thermal Sunyaev-Zel'dovich signal by PlanckPlanck. Combining the Optical spectroscopy, for the redshift determination, and photometric data from galaxy surveys (SDSS, WISE, DESI), we were able to study the structure of the two multiple-cluster systems, to determine their nature and the properties of their member galaxies. We found that the two systems are populated mainly with passive galaxies and that PLCKG214.6+36.9214.6+36.9 consists of a pair of clusters at redshift z=0.445z = 0.445 and a background isolated cluster at z=0.498z = 0.498, whereas the system PLCKG334.838.0334.8-38.0 is a chance association of three independent clusters at redshifts z=0.367z = 0.367, z=0.292z =0.292, and z=0.33z = 0.33. We also find evidence for remaining star formation activity in the highest-redshift cluster of PLCKG214.6+36.9214.6+36.9, at z=0.498z = 0.498.Comment: 12 pages, 9 Figures, 5 Tables. Submitted to A&A, comments are welcom

    Electrical Switching Dynamics in Circular and Rectangular Ge2Sb2Te5 Nanopillar Phase Change Memory Devices

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    We have measured the critical phase change conditions induced by electrical pulses in Ge2Sb2Te5 nanopillar phase change memory devices by constructing a comprehensive resistance map as a function of pulse parameters (width, amplitude and trailing edge). Our measurements reveal that the heating scheme and the details of the contact geometry play the dominant role in determining the final phase composition of the device such that a non-uniform heating scheme promotes partial amorphization/crystallization for a wide range of pulse parameters enabling multiple resistance levels for data storage applications. Furthermore we find that fluctuations in the snap-back voltage and set/reset resistances in repeated switching experiments are related to the details of the current distribution such that a uniform current injection geometry (i.e. circular contact) favors more reproducible switching parameters. This shows that possible geometrical defects in nanoscale phase change memory devices may play an essential role in the performance of the smallest possible devices through modification of the exact current distribution in the active chalcogenide layer. We present a three-dimensional finite element model of the electro-thermal physics to provide insights into the underlying physical mechanisms of the switching dynamics as well as to quantitatively account for the scaling behaviour of the switching currents in both circular and rectangular contact geometries. The calculated temporal evolution of the heat distribution within the pulse duration shows distinct features in rectangular contacts providing evidence for locally hot spots at the sharp corners of the current injection site due to current crowding effects leading to the observed behaviour

    Stochastic search and joint fine-mapping increases accuracy and identifies previously unreported associations in immune-mediated diseases

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    Abstract: Thousands of genetic variants are associated with human disease risk, but linkage disequilibrium (LD) hinders fine-mapping the causal variants. Both lack of power, and joint tagging of two or more distinct causal variants by a single non-causal SNP, lead to inaccuracies in fine-mapping, with stochastic search more robust than stepwise. We develop a computationally efficient multinomial fine-mapping (MFM) approach that borrows information between diseases in a Bayesian framework. We show that MFM has greater accuracy than single disease analysis when shared causal variants exist, and negligible loss of precision otherwise. MFM analysis of six immune-mediated diseases reveals causal variants undetected in individual disease analysis, including in IL2RA where we confirm functional effects of multiple causal variants using allele-specific expression in sorted CD4+ T cells from genotype-selected individuals. MFM has the potential to increase fine-mapping resolution in related diseases enabling the identification of associated cellular and molecular phenotypes

    Star Formation Rate Indicators in Wide-Field Infrared Survey Preliminary Release

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    With the goal of investigating the degree to which theMIR luminosity in theWidefield Infrared Survey Explorer (WISE) traces the SFR, we analyze 3.4, 4.6, 12 and 22 {\mu}m data in a sample of {\guillemotright} 140,000 star-forming galaxies or star-forming regions covering a wide range in metallicity 7.66 < 12 + log(O/H) < 9.46, with redshift z < 0.4. These star-forming galaxies or star-forming regions are selected by matching the WISE Preliminary Release Catalog with the star-forming galaxy Catalog in SDSS DR8 provided by JHU/MPA 1.We study the relationship between the luminosity at 3.4, 4.6, 12 and 22 {\mu}m from WISE and H\alpha luminosity in SDSS DR8. From these comparisons, we derive reference SFR indicators for use in our analysis. Linear correlations between SFR and the 3.4, 4.6, 12 and 22 {\mu}m luminosity are found, and calibrations of SFRs based on L(3.4), L(4.6), L(12) and L(22) are proposed. The calibrations hold for galaxies with verified spectral observations. The dispersion in the relation between 3.4, 4.6, 12 and 22 {\mu}m luminosity and SFR relates to the galaxy's properties, such as 4000 {\deg}A break and galaxy color.Comment: 10 pages, 3 figure

    Low-pass shotgun sequencing of the barley genome facilitates rapid identification of genes, conserved non-coding sequences and novel repeats

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    BACKGROUND: Barley has one of the largest and most complex genomes of all economically important food crops. The rise of new short read sequencing technologies such as Illumina/Solexa permits such large genomes to be effectively sampled at relatively low cost. Based on the corresponding sequence reads a Mathematically Defined Repeat (MDR) index can be generated to map repetitive regions in genomic sequences. RESULTS: We have generated 574 Mbp of Illumina/Solexa sequences from barley total genomic DNA, representing about 10% of a genome equivalent. From these sequences we generated an MDR index which was then used to identify and mark repetitive regions in the barley genome. Comparison of the MDR plots with expert repeat annotation drawing on the information already available for known repetitive elements revealed a significant correspondence between the two methods. MDR-based annotation allowed for the identification of dozens of novel repeat sequences, though, which were not recognised by hand-annotation. The MDR data was also used to identify gene-containing regions by masking of repetitive sequences in eight de-novo sequenced bacterial artificial chromosome (BAC) clones. For half of the identified candidate gene islands indeed gene sequences could be identified. MDR data were only of limited use, when mapped on genomic sequences from the closely related species Triticum monococcum as only a fraction of the repetitive sequences was recognised. CONCLUSION: An MDR index for barley, which was obtained by whole-genome Illumina/Solexa sequencing, proved as efficient in repeat identification as manual expert annotation. Circumventing the labour-intensive step of producing a specific repeat library for expert annotation, an MDR index provides an elegant and efficient resource for the identification of repetitive and low-copy (i.e. potentially gene-containing sequences) regions in uncharacterised genomic sequences. The restriction that a particular MDR index can not be used across species is outweighed by the low costs of Illumina/Solexa sequencing which makes any chosen genome accessible for whole-genome sequence sampling
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