The Salience of Vomiting in Teenagers Binge Drinking Intentions

Binge drinking among Australian teenagers has been identified as a serious health issue. Unfortunately, efforts to date to address this problem have been largely ineffective. It has been suggested that using images of teenagers vomiting in social marketing campaigns isn’t effective because vomiting is viewed as a positive outcome due its ability to signify a ‘big night’. The present study accessed online information posted by Australian teenagers to explore alcohol-related beliefs and behaviours that are reported online. A thematic analysis of the blogs suggests that for many Australian teenagers vomiting is still a deterrent to heavy drinking, and that they may be turning to illicit drugs to achieve an altered mental state with a lower risk of vomiting

Factors Associated with Poly Drug Use in Adolescents

Poly drug use in adolescents represents a significant public health issue, heightening risk for abuse, dependency, and a variety of short- and long-term psychological, psychosocial, and health consequences. However, past studies have typically examined just one or two substances in isolation and there is a lack of research that has comprehensively examined possible predictors of poly drug use in adolescents. To inform the development of comprehensive prevention programs that can simultaneously target multiple substances, the present study sought to identify psychological, environmental, and demographic factors that are most strongly associated with alcohol, tobacco, and cannabis poly drug use. Adolescents aged 15 to 17 years (n = 1661; 50.9% male) completed a survey on their use of alcohol, tobacco, and cannabis over the last 30 days. Various psychological, environmental, and demographic factors were also assessed. Weighted multiple-level logistic regression was conducted to assess the factors associated with poly drug use. In total, 20.3% of respondents had used at least one substance, 6.7% reported using two substances, and 3.3% reported using all three substances. The most common combined pattern of use was alcohol and tobacco, followed by alcohol and cannabis. Several factors emerged as significant, with conduct problems, depression, and the school environment accounting for the most variance. Specific psychological and environmental factors appear to be particularly important domains to target in adolescent substance use prevention programs. Early identification of adolescent depression and conduct problems and the development of programs that address these symptoms in youth may be effective approaches to delaying or preventing poly drug use in this population

A single amino acid change in Escherichia coli glycerol kinase abolishes glucose control of glycerol utilization in vivo.

Escherichia coli glycerol kinase (EC 2.7.1.30; ATP:glycerol 3-phosphotransferase) is a key element in glucose control of glycerol metabolism. Its catalytic activity is inhibited allosterically by the glycolytic intermediate, fructose 1,6-biphosphate, and by the phosphotransferase system phosphocarrier protein, IIIGlc (also known as IIAGlc). These inhibitors provide mechanisms by which glucose blocks glycerol utilization in vivo. We report here the cloning and sequencing of the glpK22 gene isolated from E. C. C. Lin strain 43, a strain that shows the loss of glucose control of glycerol utilization. DNA sequencing shows a single missense mutation that translates to the amino acid change Gly-304 to Ser (G-304-S) in glycerol kinase. The effects of this substitution on the functional and physical properties of the purified mutant enzyme were determined. Neither of the allosteric ligands inhibits it under conditions that produce strong inhibition of the wild-type enzyme, which is sufficient to explain the phenotype of strain 43. However, IIIGlc activates the mutant enzyme, which could not be predicted from the phenotype. In the wild-type enzyme, G-304 is located 1.3 nm from the active site and 2.5 nm from the IIIGlc binding site (M. Feese, D. W. Pettigrew, N. D. Meadow, S. Roseman, and S. J. Remington, Proc. Natl. Acad. Sci. USA 91:3544-3548, 1994). It is located in the same region as amino acid substitutions in the related protein DnaK which alter its catalytic and regulatory properties and which are postulated to interfere with a domain closure motion (A. S. Kamath-Loeb, C. Z. Lu, W.-C. Suh, M. A. Lonetto, and C. A. Gross, J. Biol. Chem. 270:30051-30059, 1995). The global effect of the G-304-S substitution on the conformation and catalytic and regulatory properties of glycerol kinase is consistent with a role for the domain closure motion in the molecular mechanism for glucose control of glycerol utilization

Cation-promoted association of a regulatory and target protein is controlled by protein phosphorylation.

xiv, 302 hlm, 21 c

The self in prejudice

Abstract: The self as a psychological construct, and the self in relation to the other has been discussed in psychological and sociological literature for decades, but not much attention has been given to the psychological development of the self in relation to the social construction of prejudice. The primary aim of this article is to explore the self in prejudice and thus the psychological processes involved in the development of self within the social context. Consequently, the aim is to explore the self in the construction and expression of prejudice from both a social and psychological approach, and to explain selfhood influences at the individual, group and community levels. I use the conceptual framework of Kohut’s self psychology as a lens to present the development of the self and thus the idea of the development of the self in relation to the other. In such exploration of self in prejudice, I present some of my ideas which include prejudice as an outcome of self-definition in the context of the other, as well as linking self in prejudice and group dynamics to attachment theory and the notion of “selfgroup’ in terms of overidentification with the in-group. While the social and the psychological in terms of the development of the self cannot be separated, I have therefore attempted to merge at some point the two bodies of thought in relation to the self in prejudice

Optics-less smart sensors and a possible mechanism of cutaneous vision in nature

Optics-less cutaneous (skin) vision is not rare among living organisms, though its mechanisms and capabilities have not been thoroughly investigated. This paper demonstrates, using methods from statistical parameter estimation theory and numerical simulations, that an array of bare sensors with a natural cosine-law angular sensitivity arranged on a flat or curved surface has the ability to perform imaging tasks without any optics at all. The working principle of this type of optics-less sensor and the model developed here for determining sensor performance may be used to shed light upon possible mechanisms and capabilities of cutaneous vision in nature

The future of Malay–Chinese relations in Malaysia

In this chapter, the Malay–Chinese relation is examined by considering the history and nature of the relationship, the ensuing intergroup conflict, and the steps taken by the government and civil society groups to address the conflict. Finally, a psychocultural approach to building peace between the two groups is proposed

The Relationship Between Belief and Credence

Sometimes epistemologists theorize about belief, a tripartite attitude on which one can believe, withhold belief, or disbelieve a proposition. In other cases, epistemologists theorize about credence, a fine-grained attitude that represents one’s subjective probability or confidence level toward a proposition. How do these two attitudes relate to each other? This article explores the relationship between belief and credence in two categories: descriptive and normative. It then explains the broader significance of the belief-credence connection and concludes with general lessons from the debate thus far