Economic analysis of the implementation of autologous transfusion technologies throughout England

Objectives: This study aims to provide the first estimates of the costs and effects of the large scale introduction of autologous transfusion technologies into the United Kingdom National Health Service. Methods: A model was constructed to allow disparate data sources to be combined to produce estimates of the scale, costs, and effects of introducing four interventions. The interventions considered were preparing patients for surgery (PPS) clinics, preoperative autologous donation (PAD), intraoperative cell salvage (ICS), and postoperative cell salvage (PoCS). Results: The key determinants of cost per operation are the anticipated level of reductions in blood use, the mean level of blood use, mean length of stay, and the cost of the technology. The results show the potential for considerable reductions in blood use. The greatest reductions are anticipated to be through the use of PPS and ICS. Vascular surgery, transplant surgery, and cardiothoracic surgery appear to be the specialties that will benefit most from the technologies. Conclusions: Several simplifications were used in the production of these estimates; consequently, caution should be used in their interpretation and use. Despite the drawbacks in the methods used in the study, the model shows the scale of the issue, the importance of gathering better data, and the form that data must take. Such preliminary modeling exercises are essential for rational policy development and to direct future research and discussion among stakeholders

The me in memory:the role of the self in autobiographical memory development

This paper tests the hypothesis that self development plays a role in the offset of childhood amnesia; assessing the importance of both the capacity to anchor a memory to the self-concept, and the strength of the self-concept as an anchor. We demonstrate for the first time that the volume of 3- to 6-year-old’s specific autobiographical memories is predicted by both the volume of their self-knowledge, and their capacity for self-source monitoring within self-referencing paradigms (N =186). Moreover, there is a bidirectional relationship between self and memory, such that autobiographical memory mediates the link between self-source monitoring and self-knowledge. These predictive relationships suggests that the self memory system is active in early childhood

The Search for a Realistic String Model at LHC

We survey the low-energy supersymmetry phenomenology of a three-family Pati-Salam model constructed from intersecting D6-branes in Type IIA string theory on the T^6/(Z_2 x Z_2) orientifold which possesses many of the phenomenological properties desired in string model-building. In the model, there is no exotic matter in the low-energy spectrum, the correct mass hierarchies for quarks and leptons may be obtained, and the gauge couplings are automatically unified at the string scale. We calculate the supersymmetry breaking soft terms and the corresponding low-energy supersymmetry particle spectra for the model. We find the WMAP constrained dark matter density can be generated in this model in the stau-neutralino and chargino-neutralino coannihilation regions, with expected final states at LHC consisting of low energy leptons and O(GeV) neutrinos. Moreover, we expect final states in the supercritical string cosmology (SSC) scenario to comprise high energy leptons and O(GeV) neutrinos.Comment: 35 pages, 4 figures, accepted for publication in PR

Airframe technology for aircraft energy efficiency

The economic factors that resulted in the implementation of the aircraft energy efficiency program (ACEE) are reviewed and airframe technology elements including content, progress, applications, and future direction are discussed. The program includes the development of laminar flow systems, advanced aerodynamics, active controls, and composite structures