Die Therapeutischen eigenschaften der "Kamilla-med"-Losung

U ovom radu izneti su rezultati istraživanja rastvora » Kamilla-med « , koja su izvršena na 123 bolesnika, sa progresivnim parodontopatijama, ili nekim drugim oralnim oboljenjima. Za procenu terapijskih vrednosti, korišćena su objektivna merila (indeks inflamacije). » Kamilla-med « može da se koristi kao antiseptik. Može da se koristi za smirivanje inflamatornih stanja oralne sluzokože i za ublažavanje nekih subjektivnih simptoma u ustima. Nisu poznate kontraindikacije za njegovu upotrebu.The results of the analysis of the effect of » Kamilia-Med« solution carried out in 123 patients with progressive parodontal diseases and other oral diseases are presented in this paper. The therapeutic effects of this solution were estimated by objective methods (index of inflammation). It can be used as an antiseptic as well as for the alleviation of inflammatory conditions of oral mucous membrane or for the relief of some subjective symptoms in the oral cavity. Contraindications to its use are not known.In dieser Arbeit wird über Resultate der Untersuchungen von Kamilla-Med berichtet. Bei 123 Patienten mit progressiven Parodontopathien und anderen oralen Erkrankungen, wurde Kamilla-Med angewendet. Die therapeutischen Eigenschaften wurden am Index der Inflamation gewertet. Es konnte festgestellt werden, dass Kamilia-Med ein gutes Antisepticum ist. Es mildert den entzündlichen Zustand der oralen Schleimhaut und beeinflusst günstig subjektive Symptome. Kontraindikationen sind nicht bekannt

Attitudes of Ghanaian women toward genetic testing for sickle cell trait

ObjectiveTo explore the attitudes of Ghanaian women toward genetic testing for the sickle cell trait and to investigate key factors that promote or impede the decision to pursue knowledge of the carrier status.MethodsA survey, administered in person to Ghanaian women, collected demographic information and information on the participants’ knowledge about their carrier status, their attitudes toward genetic testing, and their perceptions of the implications of being a carrier. The results for women who had previously undergone testing and those who had not were compared.ResultsOf 124 participants, 75 had been tested for the sickle cell trait and 49 had not. Some 53% of the women who had been tested did not know their carrier status. Most women agreed that getting a prenatal genetic test was important. However, nontested women were more likely to lack the financial resources to undergo testing, to think that testing is futile because sickle cell disease is not curable, and to believe that the outcome of their child’s health is determined by God.ConclusionThe women tended to have favorable attitudes toward genetic testing, but numerous barriers remained that precluded knowledge of their carrier status or the pursuit of this knowledge.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/135529/1/ijgo264.pd

Experiments with Distributed Theatre

The Tempest was probably the last play that Shakespeare wrote alone. It is unlikely that he would contemplate it being performed 400 years later, and

Contrasting Properties of α7-Selective Orthosteric and Allosteric Agonists Examined on Native Nicotinic Acetylcholine Receptors.

Subtype-selective ligands are important tools for the pharmacological characterisation of neurotransmitter receptors. This is particularly the case for nicotinic acetylcholine receptors (nAChRs), given the heterogeneity of their subunit composition. In addition to agonists and antagonists that interact with the extracellular orthosteric nAChR binding site, a series of nAChR allosteric modulators have been identified that interact with a distinct transmembrane site. Here we report studies conducted with three pharmacologically distinct nicotinic ligands, an orthosteric agonist (compound B), a positive allosteric modulator (TQS) and an allosteric agonist (4BP-TQS). The primary focus of the work described in this study is to examine the suitability of these compounds for the characterisation of native neuronal receptors (both rat and human). However, initial experiments were conducted on recombinant nAChRs demonstrating the selectivity of these three compounds for α7 nAChRs. In patch-clamp recordings on rat primary hippocampal neurons we found that all these compounds displayed pharmacological properties that mimicked closely those observed on recombinant α7 nAChRs. However, it was not possible to detect functional responses with compound B, an orthosteric agonist, using a fluorescent intracellular calcium assay on either rat hippocampal neurons or with human induced pluripotent stem cell-derived neurons (iCell neurons). This is, presumably, due to the rapid desensitisation of α7 nAChR that is induced by orthosteric agonists. In contrast, clear agonist-evoked responses were observed in fluorescence-based assays with the non-desensitising allosteric agonist 4BP-TQS and also when compound B was co-applied with the non-desensitising positive allosteric modulator TQS. In summary, we have demonstrated the suitability of subtype-selective orthosteric and allosteric ligands for the pharmacological identification and characterisation of native nAChRs and the usefulness of ligands that minimise receptor desensitisation for the characterisation of α7 nAChRs in fluorescence-based assays

Distributed Theatre: Connecting (with) Remote Audiences

In September 2014, Miracle Theatre performed “the Tempest” simultaneously at two different locations to two separate audiences. Both audiences were linked together using an advanced video system, where several cameras captured the play. This is just one example of the radical shift in performing arts, where small theatre companies can use the Internet and a range of digital tools for reaching a wider remote audience. During the last years, we have explored how tele-presence has an effect on the performing arts, on the artists, and on the audiences. This p

Ventilation and oxygenation of major trauma patients in ICU

Centrul Național Stiințifico-Practic de Medicină de Urgență, Catedra Anesteziologie Reanimatologie Nr. 1, USMF „N. Testemițanu”, Conferinţa a XI-a Naţională a ortopezilor-tramatologi din Republica Moldova “Politraumatisme – concepţii contemporane de diagnostic şi tratament”, 21 mai 2009, Chișinău, Republica MoldovaAstăzi traumatismul este comparat cu o epidemie. Unul din obiectivele de bază a managementului traumatismului major este oxigenarea și ventilația pulmonară. În articolul nostru am studiat câteva aspecte de VAP (ventilația artificială pulmonară) în traumatismele majore – indicațiile și regimurile VAP, ca unul din componenții complexului de tratament în traumatismul major cât și câteva aspecte ale strategiei ventilației pulmonare protective (protective lung ventilation).Currently trauma is recognized as an epidemic. One of priority directions in major trauma management is oxygenation and ventilation. In our article we have studied some aspects of mechanical ventilation in major trauma: indications and modes, as one important component in the management of major trauma, some aspects of use of protective lung ventilation