98 research outputs found
Automatically detecting and correcting errors in power quality monitoring data
Dependable power quality (PQ) monitoring is crucial for evaluating the impact of smart grid developments. Monitoring schemes may need to cover a relatively large network area, yet must be conducted in a cost-effective manner. Real-time communications may not be available to observe the status of a monitoring scheme or to provide time synchronization, and therefore undetected errors may be present in the data collected. This paper describes a process for automatically detecting and correcting errors in PQ monitoring data, which has been applied in an actual smart grid project. It is demonstrated how to: unambiguously recover from various device installation errors; enforce time synchronization between multiple monitoring devices and other events by correlation of measured frequency trends; and efficiently visualize PQ data without causing visual distortion, even when some data values are missing. This process is designed to be applied retrospectively to maximize the useful data obtained from a network PQ monitoring scheme, before quantitative analysis is performed. This work therefore ensures that insights gained from the analysis of the data - and subsequent network operation or planning decisions - are also valid. A case study of a UK smart grid project, involving wide-scale distribution system PQ monitoring, demonstrates the effectiveness of these contributions. All source code used for the paper is available for reuse
Revival of Philozoon Geddes for host-specialized dinoflagellates, ‘zooxanthellae’, in animals from coastal temperate zones of northern and southern hemispheres
The dinoflagellate family Symbiodiniaceae comprises numerous genera and species with large differences in diversity, ecology and
geographic distribution. An evolutionarily divergent lineage common in temperate symbiotic cnidarians and designated in the
literature by several informal names including ‘temperate–A’, AI, Phylotype A´ (A-prime) and ‘Mediterranean A’, is here assigned to
the genus Philozoon. This genus was proposed by Geddes (1882) in one of the earliest papers that recognized ‘yellow cells’ as distinct
biological entities separate from their animal and protist hosts. Using phylogenetic data from nuclear (rDNA), chloroplast (cp23S)
and mitochondrial genes (cob and cox1), as well as morphology (cell size), ecological traits (host affinity) and geographic
distributions, we emend the genus Philozoon Geddes and two of its species, P. medusarum and P. actiniarum, and describe six
new species. Each symbiont species exhibits high host fidelity for particular species of sea anemone, soft coral, stony coral and
a rhizostome jellyfish. Philozoon is most closely related to Symbiodinium (formerly Clade A), but, unlike its tropical counterpart,
occurs in hosts in shallow temperate marine habitats in northern and southern hemispheres including the Mediterranean Sea,
north-eastern Atlantic Ocean, eastern Australia, New Zealand and Chile. The existence of a species-diverse lineage adapted to
cnidarian hosts living in high latitude habitats with inherently wide fluctuations in temperature calls further attention to the
ecological and biogeographic reach of the Symbiodiniaceae
Bisabolene, a sesquiterpene from the essential oil extract of opoponax (Commiphora guidottii), exhibits cytotoxicity in breast cancer cell lines
The essential oils from Commiphora species have for centuries been recognized to possess medicinal properties. Here, we performed gas chromatography-mass spectrometry on the essential oil from opoponax (Commiphora guidotti) and identified bisabolene isomers as the main constituents of this essential oil. Opoponax essential oil, a chemical component; β-bisabolene and an alcoholic analogue, α-bisabolol, were tested for their ability to selectively kill breast cancer cells. Only β-bisabolene, a sesquiterpene constituting 5% of the essential oil, exhibited selective cytotoxic activity for mouse cells (IC50 in normal Eph4: >200 µg/ml, MG1361: 65.49 µg/ml, 4T1: 48.99 µg/ml) and human breast cancer cells (IC50 in normal MCF-10A: 114.3 µg/ml, MCF-7: 66.91 µg/ml, MDA-MB-231: 98.39 µg/ml, SKBR3: 70.62 µg/ml and BT474: 74.3 µg/ml). This loss of viability was because of the induction of apoptosis as shown by Annexin V-propidium iodide and caspase-3/7 activity assay. β-bisabolene was also effective in reducing the growth of transplanted 4T1 mammary tumours in vivo (37.5% reduction in volume by endpoint). In summary, we have identified an anti-cancer agent from the essential oil of opoponax that exhibits specific cytotoxicity to both human and murine mammary tumour cells in vitro and in vivo, and this warrants further investigation into the use of β-bisabolene in the treatment of breast cancers
Efficient Coding and Statistically Optimal Weighting of Covariance among Acoustic Attributes in Novel Sounds
To the extent that sensorineural systems are efficient, redundancy should be extracted to optimize transmission of information, but perceptual evidence for this has been limited. Stilp and colleagues recently reported efficient coding of robust correlation (r = .97) among complex acoustic attributes (attack/decay, spectral shape) in novel sounds. Discrimination of sounds orthogonal to the correlation was initially inferior but later comparable to that of sounds obeying the correlation. These effects were attenuated for less-correlated stimuli (r = .54) for reasons that are unclear. Here, statistical properties of correlation among acoustic attributes essential for perceptual organization are investigated. Overall, simple strength of the principal correlation is inadequate to predict listener performance. Initial superiority of discrimination for statistically consistent sound pairs was relatively insensitive to decreased physical acoustic/psychoacoustic range of evidence supporting the correlation, and to more frequent presentations of the same orthogonal test pairs. However, increased range supporting an orthogonal dimension has substantial effects upon perceptual organization. Connectionist simulations and Eigenvalues from closed-form calculations of principal components analysis (PCA) reveal that perceptual organization is near-optimally weighted to shared versus unshared covariance in experienced sound distributions. Implications of reduced perceptual dimensionality for speech perception and plausible neural substrates are discussed
Inferring Visuomotor Priors for Sensorimotor Learning
Sensorimotor learning has been shown to depend on both prior expectations and sensory evidence in a way that is consistent with Bayesian integration. Thus, prior beliefs play a key role during the learning process, especially when only ambiguous sensory information is available. Here we develop a novel technique to estimate the covariance structure of the prior over visuomotor transformations – the mapping between actual and visual location of the hand – during a learning task. Subjects performed reaching movements under multiple visuomotor transformations in which they received visual feedback of their hand position only at the end of the movement. After experiencing a particular transformation for one reach, subjects have insufficient information to determine the exact transformation, and so their second reach reflects a combination of their prior over visuomotor transformations and the sensory evidence from the first reach. We developed a Bayesian observer model in order to infer the covariance structure of the subjects' prior, which was found to give high probability to parameter settings consistent with visuomotor rotations. Therefore, although the set of visuomotor transformations experienced had little structure, the subjects had a strong tendency to interpret ambiguous sensory evidence as arising from rotation-like transformations. We then exposed the same subjects to a highly-structured set of visuomotor transformations, designed to be very different from the set of visuomotor rotations. During this exposure the prior was found to have changed significantly to have a covariance structure that no longer favored rotation-like transformations. In summary, we have developed a technique which can estimate the full covariance structure of a prior in a sensorimotor task and have shown that the prior over visuomotor transformations favor a rotation-like structure. Moreover, through experience of a novel task structure, participants can appropriately alter the covariance structure of their prior
The use of acetyl-CoA carboxylase activity and changes in wall composition as measures of embryogenesis in tissue cultures of oil palm (Elaeis guineensis).
With some lines of oil-palm tissue cultures embryogenesis occurs spontaneously within the callus grown on a medium containing 2.5 mg of 3-naphthylacetic acid/litre. One of the initial biochemical events that occurs just before the embryoid can be seen is the accumulation of fat droplets within the cells. This accumulation of lipid is correlated with an increase in acetyl-CoA carboxylase activity. The carboxylase is thus probably a rate-limiting step in fatty acid synthesis in these cells and can be used as a quantitative marker of somatic embryogenesis within the tissue. During the development of the embryoid tissue there is an increase in cell division and the differentiation of vascular cells with secondary thickened walls. These stages of the differentiation may be monitored by measuring the ratio of pectin synthesis (polygalacturonic acid formation) to hemicellulose synthesis (xylan formation)
Facilitation of learning induced by both random and gradual visuomotor task variation
Motor task variation has been shown to be a key ingredient in skill transfer, retention and structural learning. However, many studies only compare training of randomly varying tasks to either blocked or null training, and it is not clear how experiencing different non-random temporal orderings of tasks might affect meta-learning processes. Here we study learning in human subjects who experience the same set of visuomotor rotations, evenly spaced between -60° and +60°, either in a random order or in an order in which the rotation angle changed gradually. We compared subsequent learning of three test blocks of +30° → -30° → +30° rotations. The groups that underwent either random or gradual training showed significant (p<0.01) facilitation of learning in the test blocks compared to a control group who had not experienced any visuomotor rotations before. We also found that movement initiation times in the random group during the test blocks were significantly (p<0.05) lower than for the gradual or the control group. When we fit a state-space model with fast and slow learning processes to our data, we found that the differences in performance in the test block were consistent with the gradual or random task variation changing the learning and retention rates of only the fast learning process. Such adaptation of learning rates may be a key feature of ongoing meta-learning processes. Our results therefore suggest that both gradual and random task variation can induce meta-learning and that random learning has an advantage in terms of shorter initiation times, suggesting less reliance on cognitive processes
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