PENGARUH KOMPOSISI BIOAKTIVATOR KOTORAN SAPI DAN DAUN GAMAL (GLIRICIDIA SEPIUM) DENGAN NUTRISI UBI JALAR TERHADAP KUALITAS KOMPOS

A research conducted about effect of bioaktivator of cow feces and gamal (gliricidiasepium) leaves with sweet potato nutrition toward the compost quality. This research hadpurpose to know the compost characteristics of cow`s dung composition and gamal. Thecharacteristic determined to 60% of cow`s dung and 40% gamal leaves used purple sweetpotatoes nutrition and water that made constant. The variation of cow`s dung and gamal leaveswas 90%: 10%, 50%: 50%, 30%: 70%. The research result show that in the 14th days therewere compost characteristics to produce compost based on SNI 19-7030-2004 andrequirements of the minister of agriculture number 70/Permentan/SR.140/10/2011. Thevariations of cow`s dung and gamal leaves did not effect towards C/N ratio compost

PEMANFAATAN ABU LAYANG (FLY ASH) SEBAGAI ADSORBEN PADA MINYAK JELANTAH

A research on the conducted on the use of fly ash as an adsorbent in used cooking oil. This research was conducted with the aim to know the characteristics of fly ash without activation and activation with 6M HCl and to improve the quality of used cooking oil from adsorbent processing based on the Indonesian national standard (SNI). This research was conducted in several stages, namely surface acidity with the titration method, determination of surface area with the blue methylene method, determination of functional groups by FTIR analysis and oil quality based on parameters of acid number, peroxide number and smoke point. The results showed that the acidity of the surface of the fly ash was activated and without activation of 4 and 3.6 m2 / g respectively. surface area of ​​fly ash without activation 17,480 m2/g at contact time 80 and activated fly ash 18,471 m2/g at contact time 70. FTIR spectra of fly ash without activation 795,38 and 779.95 cm-1 and activated 795.38 and 778,02 cm-1 which is a symmetrical stretching adsorption band of symmetric ≡Si-O (≡Si-O-Si≡). Fly ash used for refining used cooking oil (2,468 mg KOH / g) is able to reduce the acid number 0.361 mg KOH / g in activated fly ash and 0.561 mg KOH / g for fly ash without activation, the peroxide number for activated fly ash decreased by 72.34% compared to fly ash without activation 69.14%, oil smoke point purification results from activated fly ash 203ºC and without activation 210ºC which is close to the new oil smoke point value of 200ºC. When compared with SNI, the values ​​of acid numbers, peroxide numbers and smoke points meet the standard

X-ray and UV spectroscopy of Galactic diffuse hot gas along the LMC X--3 sight line

We present Suzaku spectra of X-ray emission in the fields just off the LMC X-3 sight line. OVII, OVIII, and NeIX emission lines are clearly detected, suggesting the presence of an optically thin thermal plasma with an average temperature of 2.4E6. This temperature is significantly higher than that inferred from existing X-ray absorption line data obtained with Chandra grating observations of LMC X-3, strongly suggesting that the gas is not isothermal. We then jointly analyze these data to characterize the spatial and temperature distributions of the gas. Assuming a vertical exponential Galactic disk model, we estimate the gas temperature and density at the Galactic plane and their scale heights as 3.6(2.9, 4.7)E6 K and 1.4(0.3, 3.4)E-3 cm^{-3} and 1.4(0.2, 5.2) kpc and $2.8(1.0, 6.4)$ kpc, respectively. This characterization can account for all the \ovi line absorption, as observed in a FUSE spectrum of LMC X-3, but only predicts less than one tenth of the OVI line emission intensity typically detected at high Galactic latitudes. The bulk of the OVI emission most likely arises at interfaces between cool and hot gases.Comment: 10 pages, 7 figures, 3 tables, accepted for publication in ApJ, 200

Suzaku measurement of Abell 2204's intracluster gas temperature profile out to 1800 kpc

Context: Measurements of intracluster gas temperatures out to large radii are important for the use of clusters for precision cosmology and for studies of cluster physics. Previous attempts to measure robust temperatures at cluster virial radii failed. Aims: The goal of this work is to measure the temperature profile of the very relaxed galaxy cluster Abell 2204 out to large radii, possibly reaching the virial radius. Methods: Taking advantage of its low particle background due to its low-Earth orbit, Suzaku data are used to measure the outer temperature profile of Abell 2204. These data are combined with Chandra and XMM-Newton data of the same cluster in order to make the connection to the inner regions, unresolved by Suzaku, and to determine the smearing due to Suzaku's PSF. Results: The temperature profile of Abell 2204 is determined from 10 kpc to 1800 kpc, close to an estimate of r200 (the approximation to the virial radius). The temperature rises steeply from below 4 keV in the very center up to more than 8 keV in the intermediate range and then decreases again to about 4 keV at the largest radii. Varying the measured particle background normalization artificially by +-10 percent does not change the results significantly. Predictions for outer temperature profiles based on hydrodynamic simulations show good agreement. In particular, we find the observed temperature profile to be slightly steeper but consistent with a drop of a factor of 0.6 from 0.3 r200 to r200, as predicted by simulations. Conclusions: Temperature measurements up to the virial radius seem feasible with Suzaku, when a careful analysis of the different background components and the effects of the PSF is performed. The result obtained here indicates that numerical simulations capture the intracluster gas physics well in cluster outskirts.Comment: 7 pages; Astronomy and Astrophysics, accepted; additional systematic effects have been quantified, results unchanged; also available at http://www.reiprich.ne

On the lack of strong O-line excess in the Coma cluster outskirts from Suzaku

About half of the baryons in the local Universe are thought to reside in the so-called warm-hot intergalactic medium (WHIM) at temperatures of 0.1-10 million K. Thermal soft excess emission in the spectrum of some cluster outskirts that contains OVII and/or OVIII emission lines is regarded as evidence of the WHIM, although the origin of the lines is controversial due to strong Galactic and solar system foreground emission. We observed the Coma-11 field, where the most prominent thermal soft excess has ever been reported, with Suzaku XIS in order to make clear the origin of the excess. We did not confirm OVII or OVIII excess emission. The OVII and OVIII intensity in Coma-11 is more than 5 sigma below that reported before and we obtained 2 sigma upper limits of 2.8 and 2.9 photons cm^-2 s^-1 sr^-1 for OVII and OVIII, respectively. The intensities are consistent with those in another field (Coma-7) that we measured, and with other measurements in the Coma outskirts (Coma-7 and X Com fields with XMM-Newton). We did not confirm the spatial variation within Coma outskirts. The strong oxygen emission lines previously reported are likely due to solar wind charge exchange.Comment: 5 pages, 3 figures. Accepted for publication in Ap

Monte-Carlo Simulator and Ancillary Response Generator of Suzaku XRT/XIS System for Spatially Extended Source Analysis

We have developed a framework for the Monte-Carlo simulation of the X-Ray Telescopes (XRT) and the X-ray Imaging Spectrometers (XIS) onboard Suzaku, mainly for the scientific analysis of spatially and spectroscopically complex celestial sources. A photon-by-photon instrumental simulator is built on the ANL platform, which has been successfully used in ASCA data analysis. The simulator has a modular structure, in which the XRT simulation is based on a ray-tracing library, while the XIS simulation utilizes a spectral "Redistribution Matrix File" (RMF), generated separately by other tools. Instrumental characteristics and calibration results, e.g., XRT geometry, reflectivity, mutual alignments, thermal shield transmission, build-up of the contamination on the XIS optical blocking filters (OBF), are incorporated as completely as possible. Most of this information is available in the form of the FITS (Flexible Image Transport System) files in the standard calibration database (CALDB). This simulator can also be utilized to generate an "Ancillary Response File" (ARF), which describes the XRT response and the amount of OBF contamination. The ARF is dependent on the spatial distribution of the celestial target and the photon accumulation region on the detector, as well as observing conditions such as the observation date and satellite attitude. We describe principles of the simulator and the ARF generator, and demonstrate their performance in comparison with in-flight data.Comment: 19 pages with 8 figures, accepted for publication in PASJ Vol 58, Suzaku special issu

A physicochemical descriptor-based scoring scheme for effective and rapid filtering of kinase-like chemical space

<p>Abstract</p> <p>Background</p> <p>The current chemical space of known small molecules is estimated to exceed 10⁶⁰structures. Though the largest physical compound repositories contain only a few tens of millions of unique compounds, virtual screening of databases of this size is still difficult. In recent years, the application of physicochemical descriptor-based profiling, such as Lipinski's rule-of-five for drug-likeness and Oprea's criteria of lead-likeness, as early stage filters in drug discovery has gained widespread acceptance. In the current study, we outline a kinase-likeness scoring function based on known kinase inhibitors.</p> <p>Results</p> <p>The method employs a collection of 22,615 known kinase inhibitors from the ChEMBL database. A kinase-likeness score is computed using statistical analysis of nine key physicochemical descriptors for these inhibitors. Based on this score, the kinase-likeness of four publicly and commercially available databases, i.e., National Cancer Institute database (NCI), the Natural Products database (NPD), the National Institute of Health's Molecular Libraries Small Molecule Repository (MLSMR), and the World Drug Index (WDI) database, is analyzed. Three of these databases, i.e., NCI, NPD, and MLSMR are frequently used in the virtual screening of kinase inhibitors, while the fourth WDI database is for comparison since it covers a wide range of known chemical space. Based on the kinase-likeness score, a kinase-focused library is also developed and tested against three different kinase targets selected from three different branches of the human kinome tree.</p> <p>Conclusions</p> <p>Our proposed methodology is one of the first that explores how the narrow chemical space of kinase inhibitors and its relevant physicochemical information can be utilized to build kinase-focused libraries and prioritize pre-existing compound databases for screening. We have shown that focused libraries generated by filtering compounds using the kinase-likeness score have, on average, better docking scores than an equivalent number of randomly selected compounds. Beyond library design, our findings also impact the broader efforts to identify kinase inhibitors by screening pre-existing compound libraries. Currently, the NCI library is the most commonly used database for screening kinase inhibitors. Our research suggests that other libraries, such as MLSMR, are more kinase-like and should be given priority in kinase screenings.</p

Muscle wasting in chronic kidney disease: the role of the ubiquitin proteasome system and its clinical impact

Muscle wasting in chronic kidney disease (CKD) and other catabolic diseases (e.g. sepsis, diabetes, cancer) can occur despite adequate nutritional intake. It is now known that complications of these various disorders, including acidosis, insulin resistance, inflammation, and increased glucocorticoid and angiotensin II production, all activate the ubiquitin–proteasome system (UPS) to degrade muscle proteins. The initial step in this process is activation of caspase-3 to cleave the myofibril into its components (actin, myosin, troponin, and tropomyosin). Caspase-3 is required because the UPS minimally degrades the myofibril but rapidly degrades its component proteins. Caspase-3 activity is easily detected because it leaves a characteristic 14kD actin fragment in muscle samples. Preliminary evidence from several experimental models of catabolic diseases, as well as from studies in patients, indicates that this fragment could be a useful biomarker because it correlates well with the degree of muscle degradation in dialysis patients and in other catabolic conditions