Non-Gaussian bubbles in the sky

We point out a possible generation mechanism of non-Gaussian bubbles in the sky due to bubble nucleation in the early universe. We consider a curvaton scenario for inflation and assume that the curvaton field phi, whose energy density is subdominant during inflation but which is responsible for the curvature perturbation of the universe, is coupled to another field sigma which undergoes false vacuum decay through quantum tunneling. For this model, we compute the skewness of the curvaton fluctuations due to its interaction with sigma during tunneling, that is, on the background of an instanton solution that describes false vacuum decay. We find that the resulting skewness of the curvaton can become large in the spacetime region inside the bubble. We then compute the corresponding skewness in the statistical distribution of the cosmic microwave background (CMB) temperature fluctuations. We find a non-vanishing skewness in a bubble-shaped region in the sky. It can be large enough to be detected in the near future, and if detected it will bring us invaluable information about the physics in the early universe.Comment: 6 pages, 6 figure

Logarithmic mathematical morphology: a new framework adaptive to illumination changes

A new set of mathematical morphology (MM) operators adaptive to illumination changes caused by variation of exposure time or light intensity is defined thanks to the Logarithmic Image Processing (LIP) model. This model based on the physics of acquisition is consistent with human vision. The fundamental operators, the logarithmic-dilation and the logarithmic-erosion, are defined with the LIP-addition of a structuring function. The combination of these two adjunct operators gives morphological filters, namely the logarithmic-opening and closing, useful for pattern recognition. The mathematical relation existing between ``classical'' dilation and erosion and their logarithmic-versions is established facilitating their implementation. Results on simulated and real images show that logarithmic-MM is more efficient on low-contrasted information than ``classical'' MM

Forced oscillations dynamic tribometer with real-time insights of lubricated interfaces

This paper presents an innovative forced oscillations dynamic tribometer, the CHRONOS tribometer, with a lubricated ball-on-flat contact configuration fitted out with an in situ optical visualization system and a triggered high-speed camera. The CHRONOS tribometer generates controlled oscillating kinematics by means of a shaker with a range of strokes from 5 μm to 2.5 mm and an oscillation frequency which can be adjusted from 5 Hz to 250 Hz. Displacement and velocity are measured using a vibrometer. The ball-on-flat mean contact pressure is set between 200 MPa and 600 MPa. During motion, the instantaneous normal and friction forces and the interfacial film thickness distribution (in the nanometer scale) are simultaneously measured. In addition to this instantaneous approach, a more macroscopic approach is developed in terms of moving averages of friction and velocity. Another parameter, the friction-velocity tilt angle, is also introduced. This last parameter may give information on the friction-velocity dependence. Eventually, the experiments performed on the CHRONOS device lead to the representation of synchronized temporal signals of displacement/velocity, friction, and lubricant central film thickness. This superimposition of key parameters reveals time effects introduced by the periodical fluid squeeze and flow in the contact

Transcriptomes of Electrophysiologically Recorded Dbx1-derived Respiratory Neurons of the preBötzinger Complex in Neonatal Mice

Breathing depends on interneurons in the preBötzinger complex (preBötC) derived from Dbx1-expressing precursors. Here we investigate whether rhythm- and pattern-generating functions reside in discrete classes of Dbx1 preBötC neurons. In a slice model of breathing with ~ 5 s cycle period, putatively rhythmogenic Type-1 Dbx1 preBötC neurons activate 100–300 ms prior to Type-2 neurons, putatively specialized for output pattern, and 300–500 ms prior to the inspiratory motor output. We sequenced Type-1 and Type-2 transcriptomes and identified differential expression of 123 genes including ionotropic receptors (Gria3, Gabra1) that may explain their preinspiratory activation profiles and Ca2+ signaling (Cracr2a, Sgk1) involved in inspiratory and sigh bursts. Surprisingly, neuropeptide receptors that influence breathing (e.g., µ-opioid and bombesin-like peptide receptors) were only sparsely expressed, which suggests that cognate peptides and opioid drugs exert their profound effects on a small fraction of the preBötC core. These data in the public domain help explain the neural origins of breathing

Healthy aging: comparative analysis of local perception and diet in two health districts of Côte d'Ivoire and Japan

Context: Good health and longevity depend on dynamic interactions between biological, social, psychological, and environmental factors. Aging is globally a big challenge, particularly with the demographic transition, including population growth, and an emerging burden to society. Knowledge, behavior, diet, and consumption of animal source food were related to aging and emerged as the key factors modulating healthy aging. Objective: The study was designed to understand the main healthy aging factors, such as knowledge, social network, and diet of elders, and to derive mutual learning from it for healthy aging. Methods: A qualitative approach has been applied to explore health-related knowledge, attitude, and diet of elders from Ebetsu (Japan) and Tiassale (Cote d'Ivoire) health districts, using focus group discussions and comparative context analysis between high- and low-income countries. Results: The study shows that living longer is a common feature of people in Japan compared to Cote d'Ivoire, where the life expectancy is still low. Both groups of elders have social networks that support them, and both offer their gained experience to society. While Japanese elders depend on pension and insurance for income and medical treatments, Ivorians depend mostly on their children and social network in old age. The worries of elders differ between the two regions. In Ebetsu, elder members of the community are concerned about the future burden they pose for the younger generation if they develop ill-health, making them more resilient to aging. In Taabo, elders are considered to be culturally and socially useful to the society. Elders in Ebetsu pointed out that for healthy aging, education on diet at a younger age, physical activities, and access to basic social services are the key aspects. This was not observed in Taabo's context. Being inactive and dependent on others were described as the most worrying situations for elders in Ebetsu, as it is perceived to increase the risk of non-communicable diseases and anxiety. Elders in Ebetsu have good knowledge on what constitutes a healthy diet, and they believe that diversifying their diet, reducing portions, and substituting red meat with good animal and vegetable proteins are best eating practices to maintain good health. In Cote d'Ivoire, the diet is imbalanced and the whole family consumes the same meal made mainly with high-energy staples and little protein. However, it is observed in both societies that adopting a good diet is very expensive. Conclusion: The consciousness of aging is universal, but healthy aging varies according to the social systems, education, and knowledge on diet transition. Physical activities, protein-energy balance in diet, and social networks are the key for healthy aging in both contexts. The challenge is to find ways to increase knowledge regarding healthy aging and to strengthen the support system so that healthy aging becomes affordable

Oocyte maturation and quality: role of cyclic nucleotides

Advance Publication first posted online on 15 July 2016 - Accepted manuscriptThe cyclic nucleotides, cAMP and cGMP, are the key molecules controlling mammalian oocyte meiosis. Their roles in oocyte biology have been at the forefront of oocyte research for decades and many of the long standing controversies in relation to the regulation of oocyte meiotic maturation are now resolved. It is now clear that the follicle prevents meiotic resumption through the actions of natriuretic peptides and cGMP inhibiting the hydrolysis of intra-oocyte cAMP and that the preovulatory gonadotrophin surge reverses these processes. The gonadotrophin surge also leads to a transient spike in cAMP in the somatic compartment of the follicle; research over the past 2 decades has conclusively demonstrated that this surge in cAMP is important for the subsequent developmental capacity of the oocyte. This is important, as oocyte in vitro maturation (IVM) systems practiced clinically do not recapitulate this cAMP surge in vitro, possibly accounting for the lower efficiency of IVM compared to clinical IVF. This review focuses in particular on this latter aspect - the role of cAMP/cGMP in the regulation of oocyte quality. We conclude that clinical practice of IVM should reflect this new understanding of the role of cyclic nucleotides, thereby creating a new generation of ART and fertility treatment options.Gilchrist RB, Luciano AM, Richani D, Zeng HT, Wang X, De Vos M, Sugimura S, Smitz J, Richard FJ and Thompson J

The HypHI project: Hypernuclear spectroscopy with stable heavy ion beams and rare isotope beams at GSI and FAIR

The HypHI collaboration aims to perform a precise hypernuclear spectroscopy with stable heavy ion beams and rare isotope beams at GSI and fAIR in order to study hypernuclei at extreme isospin, especially neutron rich hypernuclei to look insight hyperon-nucleon interactions in the neutron rich medium, and hypernuclear magnetic moments to investigate baryon properties in the nuclei. We are currently preparing for the first experiment with $^6$Li and $^{12}$C beams at 2 AGeV to demonstrate the feasibility of a precise hypernuclear spectroscopy by identifying $^{3}_{\Lambda}$H, $^{4}_{\Lambda}$H and $^{5}_{\Lambda}$He. The first physics experiment on these hypernuclei is planned for 2009. In the present document, an overview of the HypHI project and the details of this first experiment will be discussed.Comment: 5 pages, 2 figures, French-Japanese symposium 2008, Paris (France

Flat-band ferromagnetism in quantum dot superlattices

Possibility of flat-band ferromagnetism in quantum dot arrays is theoretically discussed. By using a quantum dot as a building block, quantum dot superlattices are possible. We consider dot arrays on Lieb and kagome lattices known to exhibit flat band ferromagnetism. By performing an exact diagonalization of the Hubbard Hamiltonian, we calculate the energy difference between the ferromagnetic ground state and the paramagnetic excited state, and discuss the stability of the ferromagnetism against the second nearest neighbor transfer. We calculate the dot-size dependence of the energy difference in a dot model and estimate the transition temperature of the ferromagnetic-paramagnetic transition which is found to be accessible within the present fabrication technology. We point out advantages of semiconductor ferromagnets and suggest other interesting possibilities of electronic properties in quantum dot superlattices.Comment: 15 pages, 7 figures (low resolution). High-resolution figures are available at http://www.brl.ntt.co.jp/people/tamura/Research/PublicationPapers.htm

Cumulin, an Oocyte-secreted Heterodimer of the Transforming Growth Factor-β Family, Is a Potent Activator of Granulosa Cells and Improves Oocyte Quality

Growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) are oocyte-specific growth factors with central roles in mammalian reproduction, regulating species-specific fecundity, ovarian follicular somatic cell differentiation, and oocyte quality. In the human, GDF9 is produced in a latent form, the mechanism of activation being an open question. Here, we produced a range of recombinant GDF9 and BMP15 variants, examined their in silico and physical interactions and their effects on ovarian granulosa cells (GC) and oocytes. We found that the potent synergistic actions of GDF9 and BMP15 on GC can be attributed to the formation of a heterodimer, which we have termed cumulin. Structural modeling of cumulin revealed a dimerization interface identical to homodimeric GDF9 and BMP15, indicating likely formation of a stable complex. This was confirmed by generation of recombinant heterodimeric complexes of pro/mature domains (pro-cumulin) and covalent mature domains (cumulin). Both pro-cumulin and cumulin exhibited highly potent bioactivity on GC, activating both SMAD2/3 and SMAD1/5/8 signaling pathways and promoting proliferation and expression of a set of genes associated with oocyte-regulated GC differentiation. Cumulin was more potent than pro-cumulin, pro-GDF9, pro-BMP15, or the two combined on GC. However, on cumulus-oocyte complexes, pro-cumulin was more effective than all other growth factors at notably improving oocyte quality as assessed by subsequent day 7 embryo development. Our results support a model of activation for human GDF9 dependent on cumulin formation through heterodimerization with BMP15. Oocyte-secreted cumulin is likely to be a central regulator of fertility in mono-ovular mammals