Constructing transnational solidarity: the role of campaign governance

Our inductive study of two transnational labour solidarity efforts focuses on the role of campaign governance. Specifically, we study contrasting campaign strategies, tactics and coalition structures in campaigns by two global union federations, UNI Global Union and the IUF, contextualized in terms of how these campaigns unfolded in India. Our contribution consists of two arguments. The first is that a degree of internal consistency amongst different campaign elements is important for success, and the second is that a mode of articulation that allows for local concerns in affiliate countries to find voice in global campaigns is more likely to result in concrete gains at the local level

Novel Gemcitabine Conjugated Albumin Nanoparticles: a Potential Strategy to Enhance Drug Efficacy in Pancreatic Cancer Treatment

Purpose: The present study reports a novel conjugate of gemcitabine (GEM) with bovine serum albumin (BSA) and thereof nanoparticles (GEM-BSA NPs) to potentiate the therapeutic efficacy by altering physicochemical properties, improving cellular uptake and stability of GEM. Methods: The synthesized GEM-BSA conjugate was extensively characterized by NMR, FTIR, MALDI-TOF and elemental analysis. Conjugation mediated changes in structural conformation and physicochemical properties were analysed by fluorescence, Raman and CD spectroscopy, DSC and contact angle analysis. Further, BSA nanoparticles were developed from BSA-GEM conjugate and extensively evaluated against in-vitro pancreatic cancer cell lines to explore cellular uptake pathways and therapeutic efficacy. Results: Various characterization techniques confirmed covalent conjugation of GEM with BSA. GEM-BSA conjugate was then transformed into NPs via high pressure homogenization technique with particle size 147.2 ± 7.3, PDI 0.16 ± 0.06 and ZP -19.2 ± 1.4. The morphological analysis by SEM and AFM revealed the formation of smooth surface spherical nanoparticles. Cellular uptake studies in MIA PaCa-2 (GEM sensitive) and PANC-1 (GEM resistant) pancreatic cell lines confirmed energy dependent clathrin internalization/endocytosis as a primary mechanism of NPs uptake. In-vitro cytotoxicity studies confirmed the hNTs independent transport of GEM in MIA PaCa-2 and PANC-1 cells. Moreover, DNA damage and annexin-V assay revealed significantly higher apoptosis level in case of cells treated with GEM-BSA NPs as compared to free GEM. Conclusions: GEM-BSA NPs were found to potentiate the therapeutic efficacy by altering physicochemical properties, improving cellular uptake and stability of GEM and thus demonstrated promising therapeutic potential over free drug

De-centring the securitization of asylum and migration in the European Union: Securitization, vulnerability and the role of Turkey

This article contributes to the debates on de-centring the analysis of migration governance in Europe by focusing on the potential role of external actors in the securitisation of asylum and migration in the European Union (EU). Although there has been a growing amount of literature on the securitisation of asylum and migration in the EU, the role possibly played by external actors in this securitisation process has not been considered to date. This article addresses this gap using the case of Turkey. Theoretically, it contributes to the development of the securitisation framework by de-centring the study of securitisation processes. It argues that, from the vantage point of an external actor, a securitisation process highlights the existence of a vulnerability to a specific phenomenon that is perceived to be threatening. An external actor can then decide to exploit this vulnerability for its own gain, notably by making threats that play on the fears of the other political actor. Empirically, the article demonstrates how the Turkish government has been able to exploit the vulnerability of European countries to migration flows, which had been highlighted by the social construction of asylum and migration as security issues. By repeatedly threatening to send more asylum-seekers and migrants Europe’s way, the Turkish authorities have managed to secure some significant financial and political benefits for themselves in the last few years