Assessment of General Education of Doctoral Students Matriculating in an Educational Leadership Program in a Southern New England University

Higher education usually reserves talk of “general education” to the undergraduate experience. When entering graduate schools, graduate students have dissimilar and diverse undergraduate experiences in general education. Some graduate students have benefit of a solidly constructed undergraduate curriculum, while others have experienced broad distribution or no requirements whatsoever. Demography, language, and their disciplinary curriculum serve to divide them. Interdisciplinary programs have students usually study within the confines of two or more disciplines, and still they would be studying and researching within their disciplinary structures. Even bi-lingual and multi-lingual students still act within their linguistic structures. Stimpson (2002) created a term “General Education for Graduate Education” recommending that some form of general education be provided (course work in her case) in graduate education. At the highest level of education, the doctorate, we wanted to know the influence of the doctoral program’s cohort structure (as a Professional Learning Community) and its related environment on the enhancement of a student’s general education. We hypothesized that the students’ cohort structure and peer-to-peer (conversations) interactions in various settings increased the presence of general education indicators

Fatigue behavior of hybrid and bonded single lap joints made of composite material

Joining of composite materials can be performed with different techniques and, in particular, trough mechanical fasteners, bonding, hybrid solutions. In last years, hybrid (bolted/bonded) joints are attracting the interest of several companies and scientific community, since the use of both techniques permit to overcome some critical aspects connected to the separate usage of adhesive and bolts, i.e., negative effects of the environmental conditions on adhesive, localized stresses at the notch. This paper aims to improve the knowledge about the fatigue behavior of hybrid CFRP (Carbon Fiber Reinforced Polymer) joints. For the purpose, experimental fatigue and static tests are performed on hybrid and bonded joints and the results herein discussed. Results are post-processed with the main goal to highlight the benefits led to the hybrid technique with respect to the bonding one

Towards a More Sustainable Photocatalyzed α-Arylation of Amines: Green Solvents, Catalyst Recycling and Low Loading

A more sustainable and efficient protocol for the photocatalytic α-amino arylation promoted by fac-Ir(ppy)3 was developed. Three noteworthy results were achieved: i) the replacement of toxic medium DMA with the greener solvents NBP and NHP, and the concurrent improvement of the process efficiency by lowering both the amine and the base amount; ii) the development of a recycling protocol for both the sustainable solvent NHP and the commercially available costly photocatalyst fac-Ir(ppy)3, achieving environmental and economic benefits. This approach to the photocatalyst recovery avoids very demanding catalyst structural modifications; iii) the protocol in green solvents proved to be scalable up to 10 mmol of limiting reagent, maintaining excellent performance also lowering the photocatalyst loading down to 0.05 mol%. This is the first example of photocatalytic α-arylation of amines promoted by such a low amount of catalyst. Lastly, the versatility of this approach was demonstrated by extending the use of the green solvent NBP to another photoredox process

Capillary barriers during rainfall events in pyroclastic deposits of the vesuvian area

In the present paper, the capillary barrier formation at the interface between soil layers, which is characterized by textural discontinuities, has been analyzed. This mechanism has been investigated by means of a finite element model of a two-layer soil stratification. The two considered formations, belonging to the pyroclastic succession of the “Pomici di Base” Plinian eruption (22 ka, Santacroce et al., 2008) of the Somma–Vesuvius volcano, are affected by shallow instability phenomena likely caused by progressive saturation during the rainfall events. This mechanism could be compatible with the formation of capillary barriers at the interface between layers of different grain size distributions during infiltration. One-dimensional infiltration into the stratified soil was parametrically simulated considering rainfall events of increasing intensity and duration. The variations in the suction and degree of saturation over time allowed for the evaluation of stability variations in the layers, which were assumed as part of stratified unsaturated infinite slopes

Electronic Structure of Low-Temperature Solution-Processed Amorphous Metal Oxide Semiconductors for Thin-Film Transistor Applications.

The electronic structure of low temperature, solution-processed indium-zinc oxide thin-film transistors is complex and remains insufficiently understood. As commonly observed, high device performance with mobility >1 cm2 V-1 s-1 is achievable after annealing in air above typically 250 °C but performance decreases rapidly when annealing temperatures ≤200 °C are used. Here, the electronic structure of low temperature, solution-processed oxide thin films as a function of annealing temperature and environment using a combination of X-ray photoelectron spectroscopy, ultraviolet photoelectron spectroscopy, and photothermal deflection spectroscopy is investigated. The drop-off in performance at temperatures ≤200 °C to incomplete conversion of metal hydroxide species into the fully coordinated oxide is attributed. The effect of an additional vacuum annealing step, which is beneficial if performed for short times at low temperatures, but leads to catastrophic device failure if performed at too high temperatures or for too long is also investigated. Evidence is found that during vacuum annealing, the workfunction increases and a large concentration of sub-bandgap defect states (re)appears. These results demonstrate that good devices can only be achieved in low temperature, solution-processed oxides if a significant concentration of acceptor states below the conduction band minimum is compensated or passivated by shallow hydrogen and oxygen vacancy-induced donor levels.The authors acknowledge funding from the European Union Seventh Framework Programme (FP7/2007–2013) under Grant Agreement No.°263042. J.S. wants to thank the Engineering and Physical Sciences Research Council and the A.G. Leventis Foundation for funding.This is the final version of the article. It first appeared at http://onlinelibrary.wiley.com/doi/10.1002/adfm.201404375/ful

Dietary supplementation of suckling lambs with anthocyanins: Effects on growth, carcass, oxidative and meat quality traits

The aim of this research was to assess the effect of the dietary inclusion in suckling lambs of a red orange and lemon extract rich in anthocyanins on growth performance, antioxidant status, carcass characteristics and of both dietary antioxidant addition and aging on meat fatty acids, colorimetric and antioxidant profile, and meat texture. The experiment was carried out using 44 Merino male lambs randomly assigned to two groups: one group received the red orange and lemon extract (RLE) (RLE; n = 22) and the control group (CON; n = 22) did not receive the anthocyanins. The RLE extract was orally administered (90 mg/kg of live weight) to each lamb every day from birth until slaughter (40 ± 1 days). Longissimus lumborum muscle was sampled and aged for 7 days. Rheological, colorimetric and oxidative parameters were affected by aging time and anthocyanins administration. The meat from RLE supplemented lambs had lower cooking loss and Warner-Blatzer Shear Force (WBSF) values. Moreover, thiobarbituric acid reactive substances (TBARS) and hydroperoxides were lower (P < 0.01) in RLE meat along the entire aging period, although in both groups they increased during aging (P < 0.01). The RLE addition affect yellowness values during aging, showing lower values in CON group at 7 d (P < 0.01). The RLE feed addition in able to positively affect oxidative animal status, and consequently animal welfare, enhancing meat oxidative stability and reducing colour deterioration during aging

Geminate and nongeminate recombination of triplet excitons formed by singlet fission.

We report the simultaneous observation of geminate and nongeminate triplet-triplet annihilation in a solution-processable small molecule TIPS-tetracene undergoing singlet exciton fission. Using optically detected magnetic resonance, we identify recombination of triplet pairs directly following singlet fission, as well as recombination of triplet excitons undergoing bimolecular triplet-triplet annihilation. We show that the two processes give rise to distinct magnetic resonance spectra, and estimate the interaction between geminate triplet excitons to be 60 neV.EPSRC [grant no. EP/J017361/1 and EP/G060738/1]. E. Oppenheimer Foundation and St. Catherine's College, Cambridge. NSF [CMMI- 1255494].This is the author accepted manuscript. The final version is available at http://journals.aps.org/prl/abstract/10.1103/PhysRevLett.112.238701

TRAP1-dependent regulation of p70S6K is involved in the attenuation of protein synthesis and cell migration: Relevance in human colorectal tumors

TNF receptor-associated protein 1 (TRAP1) is an HSP90 chaperone involved in stress protection and apoptosis in mitochondrial and extramitochondrial compartments. Remarkably, aberrant deregulation of TRAP1 function has been observed in several cancer types with potential new opportunities for therapeutic intervention in humans. Although previous studies by our group identified novel roles of TRAP1 in quality control of mitochondria-destined proteins through the attenuation of protein synthesis, molecular mechanisms are still largely unknown. To shed further light on the signaling pathways regulated by TRAP1 in the attenuation of protein synthesis, this study demonstrates that the entire pathway of cap-mediated translation is activated in cells following TRAP1 interference: consistently, expression and consequent phosphorylation of p70S6K and RSK1, two translation activating kinases, are increased upon TRAP1 silencing. Furthermore, we show that these regulatory functions affect the response to translational stress and cell migration in wound healing assays, processes involving both kinases. Notably, the regulatory mechanisms controlled by TRAP1 are conserved in colorectal cancer tissues, since an inverse correlation between TRAP1 and p70S6K expression is found in tumor tissues, thereby supporting the relevant role of TRAP1 translational regulation in vivo. Taken as a whole, these new findings candidate TRAP1 network for new anti-cancer strategies aimed at targeting the translational/quality control machinery of tumor cells

Hijacking SARS-CoV-2/ACE2 Receptor Interaction by Natural and Semi-synthetic Steroidal Agents Acting on Functional Pockets on the Receptor Binding Domain

The coronavirus disease 2019 (COVID-19) is a respiratory tract infection caused by the severe acute respiratory syndrome coronavirus (SARS)-CoV-2. In light of the urgent need to identify novel approaches to be used in the emergency phase, we have embarked on an exploratory campaign aimed at repurposing natural substances and clinically available drugs as potential anti-SARS-CoV2-2 agents by targeting viral proteins. Here we report on a strategy based on the virtual screening of druggable pockets located in the central β-sheet core of the SARS-CoV-2 Spike's protein receptor binding domain (RBD). By combining an in silico approach and molecular in vitro testing we have been able to identify several triterpenoid/steroidal agents that inhibit interaction of the Spike RBD with the carboxypeptidase domain of the Angiotensin Converting Enzyme (ACE2). In detail, we provide evidence that potential binding sites exist in the RBD of the SARS CoV-2 Spike protein and that occupancy of these pockets reduces the ability of the RBD to bind to the ACE2 consensus in vitro. Naturally occurring and clinically available triterpenoids such as glycyrrhetinic and oleanolic acids, as well as primary and secondary bile acids and their amidated derivatives such as glyco-ursodeoxycholic acid and semi-synthetic derivatives such as obeticholic acid reduces the RBD/ACE2 binding. In aggregate, these results might help to define novel approaches to COVID-19 based on SARS-CoV-2 entry inhibitors