A closer look at creativity as search

Publisher PD

Solar battery with interconnecting means for plural cells Patent

Solar battery with interconnecting means for plural cell

IL-17 can be protective or deleterious in murine pneumococcal pneumonia

Streptococcus pneumoniae is the major bacterial cause of community-acquired pneumonia, and the leading agent of childhood pneumonia deaths worldwide. Nasal colonization is an essential step prior to infection. The cytokine IL-17 protects against such colonization and vaccines that enhance IL-17 responses to pneumococcal colonization are being developed. The role of IL-17 in host defence against pneumonia is not known. To address this issue, we have utilized a murine model of pneumococcal pneumonia in which the gene for the IL-17 cytokine family receptor, Il17ra, has been inactivated. Using this model, we show that IL-17 produced predominantly from γδ T cells protects mice against death from the invasive TIGR4 strain (serotype 4) which expresses a relatively thin capsule. However, in pneumonia produced by two heavily encapsulated strains with low invasive potential (serotypes 3 and 6B), IL-17 significantly enhanced mortality. Neutrophil uptake and killing of the serotype 3 strain was significantly impaired compared to the serotype 4 strain and depletion of neutrophils with antibody enhanced survival of mice infected with the highly encapsulated SRL1 strain. These data strongly suggest that IL-17 mediated neutrophil recruitment to the lungs clears infection from the invasive TIGR4 strain but that lung neutrophils exacerbate disease caused by the highly encapsulated pneumococcal strains. Thus, whilst augmenting IL-17 immune responses against pneumococci may decrease nasal colonization, this may worsen outcome during pneumonia caused by some strains

Material handling device Patent

Device which separates and screens particles of soil samples for vidicon viewing in vacuum and reduced gravity environment

Initial experimental evidence that the ability to choose between items alters attraction to familiar versus novel persons in different ways for men and women

Nonhuman species may respond to novel mates with increased sexual motivation (‘The Coolidge Effect1). In humans, novel technological advances, such as online dating platforms, are thought to result in ‘Choice Overload’2. This may undermine the goal of finding a meaningful relationship3, orienting the user toward novel possible partners versus committing to a partner. Here, we used a paradigm measuring change in attraction to familiar faces (i.e. rated on second viewing4) to investigate Coolidge-like phenomena in humans primed with choice of potential online dating partners. We examined two pre-registered hypotheses (https://osf.io/xs74r/files/). First, whether experimentally priming choice (viewing a slideshow of online dating images) directly reduces the attractiveness of familiar preferred sex faces compared to our control condition. Second, whether the predicted effect is stronger for men than women given the role of the Coolidge effect in male sexual motivation5.<br/

Sky effect on solar cells calibrated at 80,000 feet

Sky radiation effects on output of solar cells at 80,000 fee