The Interaction in the Theory of Beta Decay

Abstract Not Provided

CRISPR-Cas antimicrobials: Challenges and future prospects

This is the final version. Available from PLoS via the DOI in this record.Antimicrobial resistance (AMR) poses a serious threat to modern medicine and may render common infections untreatable. The discovery of new antibiotics has come to a relative standstill during the last decade [1], and developing novel approaches to tackle the spread of AMR genes will require significant efforts in the coming years [2]. In 2014, several groups independently demonstrated how CRISPR-Cas (clustered regularly interspaced short palindromic repeats-CRISPR–associated), a bacterial immune system now widely used for genome editing, can selectively remove AMR genes from bacterial populations. Here, we discuss the current state of the field of CRISPR-Cas antimicrobials, the challenges ahead, and how they may be overcome.Biotechnology & Biological Sciences Research Council (BBSRC)Medical Research CouncilNatural Environment Research CouncilWellcome TrustEuropean Research CouncilPeople Programme (Marie Curie Actions) of the European Union’s Horizon 202

Diabetes and disordered eating behaviours in a community-based sample of australian adolescents

Background:People with diabetes have been shown to be at risk for disordered eating compared to their non-diabetic peers. However, the majority of studies have been conducted in relatively small samples drawn from clinical diabetes settings or registries. Community-based samples are required to better understand disordered eating behaviours in this population. In a large community-based population sample of Australian adolescents, this study aimed to (1) investigate disordered eating behaviours in adolescents reporting a diagnosis of diabetes compared to their non-diabetic peers and (2) test associations between disordered eating behaviours and insulin restriction.Methods:Secondary school students (n = 4854; mean (SD) age 14.4 (1.6) years; 47% boys) completed an online survey, including self-reported presence of diabetes, demographics, weight status, substance use, insulin restriction and disordered eating behaviours. Clinically meaningful cut-offs for disordered eating behaviours were generated for analysis.Results:Disordered eating behaviours, specifically self-induced vomiting (diabetes 19.2%, no diabetes 3.3%; p p p p Conclusion:There was a high rate of disordered eating behaviours in adolescents with diabetes compared to their peers without diabetes. The findings of this study may have the potential to inform future health promotion, prevention, and early intervention approaches for those with comorbid diabetes and disordered eating behaviours. Future longitudinal studies are required to evaluate disordered eating behaviours in those with diabetes over time in community-based samples

So you call that research? : mending methodological biases in strategy and organization departments of top business schools

We believe that all strategy and organization (SO) scholars should be able to decide for themselves whether to specialize in certain parts of the knowledge cycle or adopt a broader, multi-method view on the scientific process. In a situation of ―methodological pluralism‖, individuals might choose to contribute to the construction of new administrative theories by means of qualitative works like case studies, ethnographies, biographies, or grounded theory studies (e.g., see Denzin and Lincoln, 2000). Others could then specialize in testing these theories by means of experiments, surveys, or longitudinal econometric studies (e.g., see Lewis-Beck, 1987-2004). Again others could combine both approaches in Herculean attempts to conduct high-impact, integrative research with the potential to change the way we understand the field as a whole

Supersymmetric Fokker-Planck strict isospectrality

I report a study of the nonstationary one-dimensional Fokker-Planck solutions by means of the strictly isospectral method of supesymmetric quantum mechanics. The main conclusion is that this technique can lead to a space-dependent (modulational) damping of the spatial part of the nonstationary Fokker-Planck solutions, which I call strictly isospectral damping. At the same time, using an additive decomposition of the nonstationary solutions suggested by the strictly isospectral procedure and by an argument of Englefield [J. Stat. Phys. 52, 369 (1988)], they can be normalized and thus turned into physical solutions, i.e., Fokker-Planck probability densities. There might be applications to many physical processes during their transient periodComment: revised version, scheduled for PRE 56 (1 August 1997) as a B

Heavy Quark Effective Theory at Large Orders in 1/m1/m

The existing derivations of a heavy quark effective theory (HQET) are analyzed beyond the next-to-leading order in $1/m$. With one exception they are found to be incorrect. The problem is a wrong normalization of the heavy quark field in the effective theory. We argue that the correct effective theory should be given by a Foldy--Wouthuysen type field transformation to all orders in $1/m$. The renormalization of the resulting Lagrangian to order $1/m^2$ is performed allowing for inclusion of effects arising through vacuum polarization. Our results for the anomalous dimensions disagree with the existing ones. Some applications are considered.Comment: 24 pages, LaTeX, MZ-TH/93-13 (revised). Major change