Open-source resilience: a connected commons-based proposition for urban transformation

In this paper we propose the concept of ‘open-source resilience’ as a promising path towards urban transformation and greater resilience. This proposition is investigated through the process of co-designing a digital platform, providing tools for actors engaging with resilience through urban commoning processes. Such tools will have the role of sustaining commoning projects and scaling them (up and wide) by facilitating processes of knowledge-sharing and networking. To illustrate the approach, we present outcomes and observations from an initial stage of the co-design process, which resulted in a first digital prototype

Co-producing commons-based resilience: lessons from R-Urban

The co-production of resilience in European urban neighbourhoods is explored based on the experiences from a case study. Within the current ‘resilience imperative’, co-production processes involving multiple stakeholders can be a key factor for increasing cities’ resilience. Co-produced resilience processes are more successful when embedded in collaborative forms of governance such as those associated with urban commons and when fulfilling needed roles with a community. Through the application of the R-Urban approach in a neighbourhood of Colombes (near Paris), the co-production of a commons-based resilience strategy is described. This involved a group of designers as initiators and a number of citizen as stakeholders of a network of civic hubs. The specific strategies involving a participatory setting, collective governance aspects and circular economies are analysed in the light of co-production theories and practices. Internal and external challenges are identified within the implementation process. The nature of conflicts and negotiations in this co-production approach are discussed, and the role of the architects/designers as agents within the process is investigated. Reflections from this example are provided on the limits and promises of this approach and the lessons learned from R-Urban for collaborative civic resilience

Insights into the pathogenesis of nicotine addiction. Could a salivary biosensor be useful in Nicotine Replacement Therapy (NRT)?

Nicotine has gained the attention of the medical community due to its insidious addictive mechanisms which lead to chronic consumption. The multitude of compounds derived from tobacco smoke have local and systemic negative impacts, resulting in a large number of smoking-related pathologies. The present review offers insights into nicotine addiction physiopathology, as well as social and medical implications, with emphasis on its correlation with Advanced Glycation End Products (AGEs). Therapeutic strategies and new approaches to nicotine assessment and cessation treatment are discussed, noting that such strategies could take into account the possibility of slow and gradual nicotine release from a device attached to a prosthetic piece, based on salivary nicotine-concentration feedback. This approach could offer real-time and home-based self-therapy monitoring by the physician and the patient for follow-up and improve long-term cessation treatment success- Graphical abstract

Sterol Carrier Protein-2 Directly Interacts with Caveolin-1 in Vitro and in Vivo

HDL-mediated reverse-cholesterol transport as well as phosphoinositide signaling are mediated through plasma membrane microdomains termed caveolae/lipid rafts. However, relatively little is known regarding mechanism(s) whereby these lipids traffic to or are targeted to caveolae/lipid rafts. Since sterol carrier protein-2 (SCP-2) binds both cholesterol and phosphatidylinositol, the possibility that SCP-2 might interact with caveolin-1 and caveolae was examined. Double immunolabeling and laser scanning fluorescence microscopy showed that a small but significant portion of SCP-2 colocalized with caveolin-1 primarily at the plasma membrane of L-cells and more so within intracellular punctuate structures in hepatoma cells. In SCP-2 overexpressing L-cells, SCP-2 was detected in close proximity to caveolin, 48 ± 4 Å, as determined by fluorescence resonance energy transfer (FRET) and immunogold electron microscopy. Cell fractionation of SCP-2 overexpressing L-cells and Western blotting detected SCP-2 in purified plasma membranes, especially in caveolae/ lipid rafts as compared to the nonraft fraction. SCP-2 and caveolin-1 were coimmunoprecipitated from cell lysates by anti-caveolin-1 and anti-SCP-2. Finally, a yeast two-hybrid assay demonstrated that SCP-2 directly interacts with caveolin-1 in vivo. These interactions of SCP-2 with caveolin-1 were specific since a functionally related protein, phosphatidyinositol transfer protein (PITP), colocalized much less well with caveolin-1, was not in close proximity to caveolin-1 (i.e., \u3e120 Å), and was not coimmunoprecipitated by anti-caveolin-1 from cell lysates. In summary, it was shown for the first time that SCP-2 (but not PITP) selectively interacted with caveolin-1, both within the cytoplasm and at the plasma membrane. These data contribute significantly to our understanding of the role of SCP-2 in cholesterol and phosphatidylinositol targeted from intracellular sites of synthesis in the endoplasmic reticulum to caveolae/lipid rafts at the cell surface plasma membrane

A Relational Event Approach to Modeling Behavioral Dynamics

This chapter provides an introduction to the analysis of relational event data (i.e., actions, interactions, or other events involving multiple actors that occur over time) within the R/statnet platform. We begin by reviewing the basics of relational event modeling, with an emphasis on models with piecewise constant hazards. We then discuss estimation for dyadic and more general relational event models using the relevent package, with an emphasis on hands-on applications of the methods and interpretation of results. Statnet is a collection of packages for the R statistical computing system that supports the representation, manipulation, visualization, modeling, simulation, and analysis of relational data. Statnet packages are contributed by a team of volunteer developers, and are made freely available under the GNU Public License. These packages are written for the R statistical computing environment, and can be used with any computing platform that supports R (including Windows, Linux, and Mac).

Influence of parameters of welding regime on metallographic structure of materials from a joint welded in corner in „T” form

To achieve metal constructions with high importance, it can be used different steels, but steel OL 52.4k has a very wide use due to technological properties and mechanical they present. Metallographic structure of materials of a welded joint is influenced by conditions that occur in the process of welding. In the researches there have been studied the influence of parameters of welding regime on the system of metallographic structure of materials from a welded joint in corner in “T” form. There was taken into account welding process MAG using three welding regimes and using steel plates from OL 52.4k steel with a thickness of 10 / mm

Topological Photonics

Topology is revolutionizing photonics, bringing with it new theoretical discoveries and a wealth of potential applications. This field was inspired by the discovery of topological insulators, in which interfacial electrons transport without dissipation even in the presence of impurities. Similarly, new optical mirrors of different wave-vector space topologies have been constructed to support new states of light propagating at their interfaces. These novel waveguides allow light to flow around large imperfections without back-reflection. The present review explains the underlying principles and highlights the major findings in photonic crystals, coupled resonators, metamaterials and quasicrystals.Comment: progress and review of an emerging field, 12 pages, 6 figures and 1 tabl