Spatial Variations of Fundamental Constants

We show that observational limits on the possible time variation of constants of Nature are significantly affected by allowing for both space and time variation. Bekenstein's generalisation of Maxwell's equations to allow for cosmological variation of $alpha$ is investigated in a universe containing spherically symmetric inhomogeneities. The time variation of $alpha$ is determined by the local matter density and hence limits obtained in high-density geophysical enviroments are far more constraining than those obtained at high redshift. This new feature is expected to be a property of a wide class of theories for the variation of constants.Comment: 4 page

California Methanol Assessment; Volume II, Technical Report

A joint effort by the Jet Propulsion Laboratory and the California Institute of Technology Division of Chemistry and Chemical Engineering has brought together sponsors from both the public and private sectors for an analysis of the prospects for methanol use as a fuel in California, primarily for the transportation and stationary application sectors. Increasing optimism in 1982 for a slower rise in oil prices and a more realistic understanding of the costs of methanol production have had a negative effect on methanol viability in the near term (before the year 2000). Methanol was determined to have some promise in the transportation sector, but is not forecasted for large-scale use until beyond the year 2000. Similarly, while alternative use of methanol can have a positive effect on air quality (reducing NOx, SOx, and other emissions), a best case estimate is for less than 4% reduction in peak ozone by 2000 at realistic neat methanol vehicle adoption rates. Methanol is not likely to be a viable fuel in the stationary application sector because it cannot compete economically with conventional fuels except in very limited cases. On the production end, it was determined that methanol produced from natural gas will continue to dominate supply options through the year 2000, and the present and planned industry capacity is somewhat in excess of all projected needs. Nonsubsidized coal-based methanol cannot compete with conventional feedstocks using current technology, but coal-based methanol has promise in the long term (after the year 2000), providing that industry is willing to take the technical and market risks and that government agencies will help facilitate the environment for methanol. Given that the prospects for viable major markets (stationary applications and neat fuel in passenger cars) are unlikely in the 1980s and early 1990s, the next steps for methanol are in further experimentation and research of production and utilization technologies, expanded use as an octane enhancer, and selected fleet implementation. In the view of the study, it is not advantageous at this time to establish policies within California that attempt to expand methanol use rapidly as a neat fuel for passenger cars or to induce electric utility use of methanol on a widespread basis

Weak magnetic fields in white dwarfs and their direct progenitors?

We have carried out a re-analysis of polarimetric data of central stars of planetary nebulae, hot subdwarfs, and white dwarfs taken with FORS1 (FOcal Reducer and low dispersion Spectrograph) on the VLT (Very Large Telescope), and added a large number of new observations in order to increase the sample. A careful analysis of the observations using only one wavelength calibration for the polarimetrically analysed spectra and for all positions of the retarder plate of the spectrograph is crucial in order to avoid spurious signals. We find that the previous detections of magnetic fields in subdwarfs and central stars could not be confirmed while about 10% of the observed white dwarfs have magnetic fields at the kilogauss level.Comment: 6 pages, Proceedings of the 18th European White Dwarf Workshop, ASP Conference Serie

The molecular genetic analysis of the expanding pachyonychia congenita case collection

BACKGROUND: Pachyonychia congenita (PC) is a rare autosomal dominant keratinizing disorder characterized by severe, painful, palmoplantar keratoderma and nail dystrophy, often accompanied by oral leucokeratosis, cysts and follicular keratosis. It is caused by mutations in one of five keratin genes: KRT6A, KRT6B, KRT6C, KRT16 or KRT17. OBJECTIVES: To identify mutations in 84 new families with a clinical diagnosis of PC, recruited by the International Pachyonychia Congenita Research Registry during the last few years. METHODS: Genomic DNA isolated from saliva or peripheral blood leucocytes was amplified using primers specific for the PC-associated keratin genes and polymerase chain reaction products were directly sequenced. RESULTS: Mutations were identified in 84 families in the PC-associated keratin genes, comprising 46 distinct keratin mutations. Fourteen were previously unreported mutations, bringing the total number of different keratin mutations associated with PC to 105. CONCLUSIONS: By identifying mutations in KRT6A, KRT6B, KRT6C, KRT16 or KRT17, this study has confirmed, at the molecular level, the clinical diagnosis of PC in these families

Cool Jupiters greatly outnumber their toasty siblings : Occurrence rates from the Anglo-Australian Planet Search

This article has been accepted for publication in Monthly Notices of the Royal Astronomical Society ©2019 The Authors. Published by Oxford University Press on behalf of the Royal Astronomical Society. All rights reserved.Our understanding of planetary systems different to our own has grown dramatically in the past 30 yr. However, our efforts to ascertain the degree to which the Solar system is abnormal or unique have been hindered by the observational biases inherent to the methods that have yielded the greatest exoplanet hauls. On the basis of such surveys, one might consider our planetary system highly unusual - but the reality is that we are only now beginning to uncover the true picture. In this work, we use the full 18-yr archive of data from the Anglo-Australian Planet Search to examine the abundance of 'cool Jupiters' - analogues to the Solar system's giant planets, Jupiter and Saturn. We find that such planets are intrinsically far more common through the cosmos than their siblings, the hot Jupiters.We find that the occurrence rate of such 'cool Jupiters' is 6.73 +2.09 -1.13 per cent, almost an order of magnitude higher than the occurrence of hot Jupiters (at 0.84 +0.70 -0.20 per cent). We also find that the occurrence rate of giant planets is essentially constant beyond orbital distances of ~1 au. Our results reinforce the importance of legacy radial velocity surveys for the understanding of the Solar system's place in the cosmos.Peer reviewe

In silico identification of bacteriocin gene clusters in the gastrointestinal tract, based on the Human Microbiome Project’s reference genome database

peer-reviewedBackground The human gut microbiota comprises approximately 100 trillion microbial cells which significantly impact many aspects of human physiology - including metabolism, nutrient absorption and immune function. Disturbances in this population have been implicated in many conditions and diseases, including obesity, type-2 diabetes and inflammatory bowel disease. This suggests that targeted manipulation or shaping of the gut microbiota, by bacteriocins and other antimicrobials, has potential as a therapeutic tool for the prevention or treatment of these conditions. With this in mind, several studies have used traditional culture-dependent approaches to successfully identify bacteriocin-producers from the mammalian gut. In silico-based approaches to identify novel gene clusters are now also being utilised to take advantage of the vast amount of data currently being generated by next generation sequencing technologies. In this study, we employed an in silico screening approach to mine potential bacteriocin clusters in genome-sequenced isolates from the gastrointestinal tract (GIT). More specifically, the bacteriocin genome-mining tool BAGEL3 was used to identify potential bacteriocin producers in the genomes of the GIT subset of the Human Microbiome Project’s reference genome database. Each of the identified gene clusters were manually annotated and potential bacteriocin-associated genes were evaluated. Results We identified 74 clusters of note from 59 unique members of the Firmicutes, Bacteroidetes, Actinobacteria, Fusobacteria and Synergistetes. The most commonly identified class of bacteriocin was the >10 kDa class, formerly known as bacteriolysins, followed by lantibiotics and sactipeptides. Conclusions Multiple bacteriocin gene clusters were identified in a dataset representative of the human gut microbiota. Interestingly, many of these were associated with species and genera which are not typically associated with bacteriocin production.CJW, CMG and PDC are supported by a SFI PI award to PDC “Obesibiotics” (11/PI/1137)

First Kepler results on compact pulsators VII. Pulsating subdwarf B stars detected in the second half of the survey phase

We present five new pulsating subdwarf B (sdB) stars discovered by the Kepler spacecraft during the asteroseismology survey phase. We perform time-series analysis on the nearly continuous month-long Kepler datasets of these 5 objects; these datasets provide nearly alias-free time-series photometry at unprecedented precision. Following an iterative prewhitening process we derive the pulsational frequency spectra of these stars, separating out artefacts of known instrumental origin. We find that these new pulsating sdB stars are multiperiodic long-period pulsators of the V1093 Her type, with the number of periodicities ranging from 8 (KIC8302197) to 53 (KIC11558725). The frequencies and amplitudes are typical of g-mode pulsators of this type. We do not find any evidence for binarity in the five stars from their observed pulsation frequencies. As these are g-mode pulsators, we briefly looked for period spacings for mode identification, and found average spacings about 260s and 145s. This may indicate l=1 and 2 patterns. Some modes may show evidence of rotational splitting. These discoveries complete the list of compact pulsators found in the survey phase. Of the 13 compact pulsators, only one star was identified as a short-period (p-mode) V361Hya pulsator, while all other new pulsators turned out to be V1093 Her class objects. Among the latter objects, two of them seemed to be pure V1093 Her while the others show additional low amplitude peaks in the p-mode frequency range, suggesting their hybrid nature. Authenticity of these peaks will be tested with longer runs currently under analysis.Comment: accepted for publication in MNRA

Exoplanet properties from Lick, Keck and AAT

Doppler-shift measurements with a remarkable precision of Δλ/λ=3×10-9, corresponding to velocities of 1 m s-1, have been made repeatedly of 2500 stars located within 300 light years. The observed gravitational perturbations of the stars have revealed 250 orbiting planets, with 27 that cross in front of the host star, blocking a fraction of the starlight to allow measurement of the planet's mass, radius and density. Two new discoveries are the first good analog of Jupiter (HD 154345b) and the first system of five planets (55 Cancri). The predominantly eccentric orbits of exoplanets probably result from planet planet gravitational interactions or angular momentum exchange by mean-motion resonances. The planet mass distribution ranges from ~15 MJUP to as low as ~5 MEarth and rises toward lower masses as dN/dM~M-1.1. The distribution with orbital distance, a, rises (in logarithmic intervals) as dN/d log a~a+0.4. Extrapolation and integration suggests that 19% of all Sun-like stars harbor a gas-giant planet within 20 AU, but there remains considerable incompleteness for large orbits. Beyond 20 AU, the occurrence of gas-giant planets may be less than a few per cent as protoplanetary disk material there has lower densities and is vulnerable to destruction. Jupiter-mass planets occur more commonly around more massive stars than low mass stars. The transit of the Neptune-mass planet, Gliese 436b, yields a density of 1.55 g cm-3 suggesting that its interior has an iron silicate core surrounded by an envelope of water ice and an outer H He shell. Planets with masses as low as five Earth-masses may be commonly composed of iron nickel, rock and water along with significant amounts of H and He, making the term 'super-Earth' misleading. The transiting planet HD147506b has high orbital eccentricity but no significant orbital inclination to the line of sight, presenting a puzzle about its history. Its orbit together with the mean motion resonances of 4 of the 22 multi-planet systems provides further evidence for the role of planet planet interactions in shaping planetary architectures

Polysaccharide utilization loci and nutritional specialization in a dominant group of butyrate-producing human colonic Firmicutes

Acknowledgements The Rowett Institute of Nutrition and Health (University of Aberdeen) receives financial support from the Scottish Government Rural and Environmental Sciences and Analytical Services (RESAS). POS is a PhD student supported by the Scottish Government (RESAS) and the Science Foundation Ireland, through a centre award to the APC Microbiome Institute, Cork, Ireland. Data Summary The high-quality draft genomes generated in this work were deposited at the European Nucleotide Archive under the following accession numbers: 1. Eubacterium rectale T1-815; CVRQ01000001–CVRQ0100 0090: http://www.ebi.ac.uk/ena/data/view/PRJEB9320 2. Roseburia faecis M72/1; CVRR01000001–CVRR010001 01: http://www.ebi.ac.uk/ena/data/view/PRJEB9321 3. Roseburia inulinivorans L1-83; CVRS01000001–CVRS0 100 0151: http://www.ebi.ac.uk/ena/data/view/PRJEB9322Peer reviewedPublisher PD