The Interaction of Motivational Orientation and Social Context in a Flight Setting

The purpose of this study was to explore the effects of motivational orientation and social context on decisions made during flight. Cultural dimensions such as power distance, uncertainty avoidance and individualism have been found to correlate with aviation accident rates. Self-determination theory provides a schedule of social contexts and cues that support, control or thwart individual motivation, with the task-focused properties of intrinsic motivation and the external (group) focus of extrinsic motivation similar to descriptions of the cultural dimensions of individualism and collectivism. In addition, studies have demonstrated contextual cues may be used to prime cognitive goals, behaviors and strategies. The motivational orientation of 48 instrument pilots was measured prior to their participation in a simulated flight exercise that contained contextual primes to continue into or turn away from adverse weather conditions. Extrinsically motivated participants were observed to be vulnerable to external suggestions. This vulnerability has the potential to affect decisions made in flight. Risk assessment programs and reducing controlling factors in the flight environment can be used to mitigate this phenomenon

TGF-β Receptors PAR-ticipate in Axon Formation

How does a newborn neuron initiate and elaborate an axon? Using cutting-edge approaches, Yi et al. (2010) provide striking evidence that TGF-β signaling via the Par polarity complex is required for axon formation by neocortical pyramidal neurons

Size-Selectivity Of The Northwest Atlantic Sea Scallop (Placopecten Magellanicus) Dredge

A size-selectivity curve was constructed to characterize the performance of the New Bedford style Atlantic sea scallop (Placopecten magellanicus, Gmelin 1791) dredge when it is configured to meet the requirements of Amendment #10 to the Sea Scallop Fishery Management Plan. The curve was generated using the SELECT model on catch-at-length data, obtained by simultaneously towing a New Bedford style dredge and a nonselective National Marine Fisheries Service sea scallop survey dredge from commercial scallop vessels. Data were collected during three cruises in the Northwest Atlantic between 2005 and 2006. The resultant selectivity curve yielded a 50% retention length of 100.1 mm, a selection range of 23.6 mm, and a value of 0.77 for the efficiency of the commercial dredge relative to the survey dredge. A length of 100.1 mm corresponds to a meat weight of 17.2 g in Georges Bank and 16.8 g in the mid-Atlantic. These results can assist fisheries managers with stock assessments, fishing mortality estimates, and the interpretation of catch data from resource surveys. Additionally, the curve can be used as a baseline to evaluate the effect of future changes to sea scallop dredge configuration

Comparison of Blood and Brain Mercury Levels in Infant Monkeys Exposed to Methylmercury or Vaccines Containing Thimerosal

Thimerosal is a preservative that has been used in manufacturing vaccines since the 1930s. Reports have indicated that infants can receive ethylmercury (in the form of thimerosal) at or above the U.S. Environmental Protection Agency guidelines for methylmercury exposure, depending on the exact vaccinations, schedule, and size of the infant. In this study we compared the systemic disposition and brain distribution of total and inorganic mercury in infant monkeys after thimerosal exposure with those exposed to MeHg. Monkeys were exposed to MeHg (via oral gavage) or vaccines containing thimerosal (via intramuscular injection) at birth and 1, 2, and 3 weeks of age. Total blood Hg levels were determined 2, 4, and 7 days after each exposure. Total and inorganic brain Hg levels were assessed 2, 4, 7, or 28 days after the last exposure. The initial and terminal half-life of Hg in blood after thimerosal exposure was 2.1 and 8.6 days, respectively, which are significantly shorter than the elimination half-life of Hg after MeHg exposure at 21.5 days. Brain concentrations of total Hg were significantly lower by approximately 3-fold for the thimerosal-exposed monkeys when compared with the MeHg infants, whereas the average brain-to-blood concentration ratio was slightly higher for the thimerosal-exposed monkeys (3.5 ± 0.5 vs. 2.5 ± 0.3). A higher percentage of the total Hg in the brain was in the form of inorganic Hg for the thimerosal-exposed monkeys (34% vs. 7%). The results indicate that MeHg is not a suitable reference for risk assessment from exposure to thimerosal-derived Hg. Knowledge of the toxicokinetics and developmental toxicity of thimerosal is needed to afford a meaningful assessment of the developmental effects of thimerosal-containing vaccines

Heterotic compactifications on nearly Kahler manifolds

We consider compactifications of heterotic supergravity on anti-de Sitter space, with a six-dimensional nearly Kahler manifold as the internal space. Completing the model proposed by Frey and Lippert [10] with the particular choice of SU(3)/U(1)xU(1) for the internal manifold, we show that it satisfies not only the supersymmetry constraints but also the equations of motion with string corrections of order alpha'. Furthermore, we present a non-supersymmetric model. In both solutions we find confirmed a recent result of Ivanov [18] on the connection used for anomaly cancellation. Interestingly, the volume of the internal space is fixed by the supersymmetry constraints and/or the equations of motion.DFG/EXC/QUESTHeisenberg-Landau programRFBR/09-02-9134

Pilot Safety Evaluation of Varenicline for the Treatment of Methamphetamine Dependence.

Despite the worldwide extent of methamphetamine dependence, no medication has been shown to effectively treat afflicted individuals. One relatively unexplored approach is modulation of cholinergic system function. Animal research suggests that enhancement of central cholinergic activity, possibly at nicotinic acetylcholine receptors (nAChRs), can reduce methamphetamine-related behaviors. Further, preliminary findings indicate that rivastigmine, a cholinesterase inhibitor, may reduce craving for methamphetamine after administration of the drug in human subjects. We therefore performed a double-blind, placebo-controlled, crossover pilot study of the safety and tolerability of varenicline in eight methamphetamine-dependent research subjects. Varenicline is used clinically to aid smoking cessation, and acts as a partial agonist at α4β2 nAChRs with full agonist properties at α7 nAChRs. Oral varenicline dose was titrated over 1 week to reach 1 mg bid, and then was co-administered with 30 mg methamphetamine, delivered in ten intravenous infusions of 3 mg each. Varenicline was found to be safe in combination with IV methamphetamine, producing no cardiac rhythm disturbances or alterations in vital sign parameters. No adverse neuropsychiatric sequelae were detected either during varenicline titration or following administration of methamphetamine. The results suggest that varenicline warrants further investigation as a potential treatment for methamphetamine dependence

CD40-CD40 Ligand Interactions in Experimental Allergic Encephalomyelitis and Multiple Sclerosis.

We investigated the role of CD40-CD40 ligand (CD40L) interactions in multiple sclerosis (MS) and experimental allergic encephalomyelitis (EAE). Activated helper T cells expressing CD40L (gp39) surface protein were found in MS patient brain sections, but not in brain tissue sections of normal controls or patients with other neurological disease. CD40L-positive cells were co-localized with CD40-bearing cells in active lesions (perivascular infiltrates). Most of these CD40-bearing cells proved to be of the monocytic lineage (macrophages or microglial cells), and relatively few were B cells. To functionally evaluate CD40-CD40L interactions, EAE was elicited in mice by means of proteolipid-peptide immunization. Treatment with anti-CD40L monoclonal antibody completely prevented the development of disease. Furthermore, administration of anti-CD40L monoclonal antibody, even after disease onset, shortly before maximum disability score was reached led to dramatic disease reduction. The presence of helper T cells expressing CD40L in brain tissue of MS patients and EAE animals, together with the functional evidence provided by successful experimental prevention and therapy in an animal model, indicates that blockade of CD40-CD40L-mediated cellular interactions may be a method for interference in active MS

Neuroprotective efficacy of P7C3 compounds in primate hippocampus.

There is a critical need for translating basic science discoveries into new therapeutics for patients suffering from difficult to treat neuropsychiatric and neurodegenerative conditions. Previously, a target-agnostic in vivo screen in mice identified P7C3 aminopropyl carbazole as capable of enhancing the net magnitude of postnatal neurogenesis by protecting young neurons from death. Subsequently, neuroprotective efficacy of P7C3 compounds in a broad spectrum of preclinical rodent models has also been observed. An important next step in translating this work to patients is to determine whether P7C3 compounds exhibit similar efficacy in primates. Adult male rhesus monkeys received daily oral P7C3-A20 or vehicle for 38 weeks. During weeks 2-11, monkeys received weekly injection of 5'-bromo-2-deoxyuridine (BrdU) to label newborn cells, the majority of which would normally die over the following 27 weeks. BrdU+ cells were quantified using unbiased stereology. Separately in mice, the proneurogenic efficacy of P7C3-A20 was compared to that of NSI-189, a proneurogenic drug currently in clinical trials for patients with major depression. Orally-administered P7C3-A20 provided sustained plasma exposure, was well-tolerated, and elevated the survival of hippocampal BrdU+ cells in nonhuman primates without adverse central or peripheral tissue effects. In mice, NSI-189 was shown to be pro-proliferative, and P7C3-A20 elevated the net magnitude of hippocampal neurogenesis to a greater degree than NSI-189 through its distinct mechanism of promoting neuronal survival. This pilot study provides evidence that P7C3-A20 safely protects neurons in nonhuman primates, suggesting that the neuroprotective efficacy of P7C3 compounds is likely to translate to humans as well