448 research outputs found

    Aerothermochemical Nonequilibrium Modeling for Oxygen Flows

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    Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/143077/1/1.T4962.pd

    Hanford Site National Environmental Policy Act (NEPA) characterization. Revision 9

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    This ninth revision of the Hanford Site National Environmental Policy Act (NEPA) Characterization presents current environmental data regarding the hanford Site and its immediate environs. This information is intended for use in preparing Chapters 4 and 6 in Hanford Site-related NEPA documents. Chapter 4.0 (Affected Environment) includes information on climate and meteorology, geology, hydrology, ecology, cultural, archaeological and historical resources, socioeconomics, and noise. Chapter 6.0 (Statutory and Regulatory Requirements) provides the preparer with the federal and state regulations, DOE directives and permits, and environmental standards directly applicable to the NEPA documents on the Hanford Site. Not all of the sections have been updated for this revision. The following lists the updated sections: climate and meteorology; ecology (threatened and endangered species section only); culture, archaeological, and historical resources; socioeconomics; all of Chapter 6

    SURVEY OF COLUMBIA RIVER BASIN STREAMS FOR COLUMBIA PEBBLESNAIL Fluminicola columbiana AND SHORTFACE LANX Fisherola nuttalli

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    At present, there are only two remaining sizable populations of Columbia pebblesnail Fluminicola columbiana; those in the Methow and Okanogan rivers, Washington. Smaller populations survive in the Hanford Reach of the Columbia River, Washington; the lower Salmon River and middle Snake River, Idaho; and possibly in Hells Canyon of the Snake River, Idaho, Washington, and Oregon; and the Grande Ronde River, Oregon and Washington. Neither large population is at present protected, and there has been a substantial documented reduction in the species' historical range. Large populations of the shortface lanx Fisherola nuttalli persist in four streams: the Deschutes River, Oregon; the Hanford Reach of the Columbia River, Washington; Hells Canyon of the Snake River, Idaho and Oregon; and the Okanogan River, Washington. Smaller populations, or ones of uncertain size, are known from the lower Salmon and middle Snake rivers, Idaho; the Grande Ronde, Washington and Oregon; Imnaha and John Day rivers, Oregon; Bonneville Dam area of the Columbia River, Washington and Oregon; and the Methow River, Washington. While substantial range reduction has occurred in this species, and the large populations are not well protected, the problem is not as severe as in the case of the Columbia pebblesnail. Both species appear to have been widespread historically in the mainstem Columbia River and the Columbia River Basin prior to the installation of the current dam system. Both are now apparently reduced within the Columbia River: Columbia pebblesnail to a population in the Hanford Reach plus six other sites that are separated by large areas of unsuitable habitat from those in the river's major mbutaries shortface lanx to two populations (in the Hanford Reach and near Bonneville Dam) plus nine other sites that are separated by large areas of unsuitable habitat from those in the river's major tributaries

    COMPETITION AMONG HOSPITALS AND ITS MEASUREMENT: THEORY AND A CASE STUDY

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    Our paper provides several insights on the characteristics of the concept of “Poles d’Excellence Rurale” (PER) through bilateral comparisons with that of Competitive Pole (CP) and cluster. The concept of PER is a French government’ initiative designed for the development of rural areas similar to that of the Competitive Pole. We emphasize important particularities of these concepts by analyzing some of their similarities and major differences.Pole d’Excellence Rurale, Competitive Pole, cluster, rural development

    Hanford Site National Environmental Policy Act (NEPA) characterization. Revision 10

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    This document describes the US Department of Energy`s (DOE) Hanford Site environment and is numbered to correspond to the chapters where such information is presented in Hanford Site NEPA related documents. The document is intended to provide a consistent description of the Hanford Site environment for the many NEPA documents that are being prepared by contractors. The two chapters in this document (Chapters 4 and 6) are numbered this way to correspond to the chapters where such information is presented in environmental impact statements (EISs) and other Site-related NEPA or CERCLA documentation. Chapter 4.0 (Affected Environment) describes the Hanford Site environment, and includes information on climate and meteorology, geology, hydrology, ecology, cultural, archaeological and historical resources, socioeconomics, and noise. Chapter 6.0 (Statutory and Regulatory Requirements) describes applicable federal and state laws and regulations, DOE directives and permits, and environmental standards directly applicable to the NEPA documents on the Hanford Site

    Impaired visual short-term memory capacity is distinctively associated with structural connectivity of the posterior thalamic radiation and the splenium of the corpus callosum in preterm-born adults

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    Preterm birth is associated with an increased risk for lasting changes in both the cortico-thalamic system and attention; however, the link between cortico-thalamic and attention changes is as yet little understood. In preterm newborns, cortico-cortical and cortico-thalamic structural connectivity are distinctively altered, with increased local clustering for cortico-cortical and decreased integrity for cortico-thalamic connectivity. In preterm-born adults, among the various attention functions, visual short-term memory (vSTM) capacity is selectively impaired. We hypothesized distinct associations between vSTM capacity and the structural integrity of cortico-thalamic and cortico-cortical connections, respectively, in preterm-born adults. A whole-report paradigm of briefly presented letter arrays based on the computationally formalized Theory of Visual Attention (TVA) was used to quantify parameter vSTM capacity in 26 preterm- and 21 full-term-born adults. Fractional anisotropy (FA) of posterior thalamic radiations and the splenium of the corpus callosum obtained by diffusion tensor imaging were analyzed by tract-based spatial statistics and used as proxies for cortico-thalamic and cortico-cortical structural connectivity. The relationship between vSTM capacity and cortico-thalamic and cortico-cortical connectivity, respectively, was significantly modified by prematurity. In full-term-born adults, the higher FA in the right posterior thalamic radiation the higher vSTM capacity; in preterm-born adults this FA-vSTM-relationship was inversed. In the splenium, higher FA was correlated with higher vSTM capacity in preterm-born adults, whereas no significant relationship was evident in full-term-born adults. These results indicate distinct associations between cortico-thalamic and cortico-cortical integrity and vSTM capacity in preterm-and full-term-born adults. Data suggest compensatory cortico-cortical fiber re-organization for attention deficits after preterm delivery

    Microcephalin and pericentrin regulate mitotic entry via centrosome-associated Chk1

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    Primary microcephaly, Seckel syndrome, and microcephalic osteodysplastic primordial dwarfism type II (MOPD II) are disorders exhibiting marked microcephaly, with small brain sizes reflecting reduced neuron production during fetal life. Although primary microcephaly can be caused by mutations in microcephalin (MCPH1), cells from patients with Seckel syndrome and MOPD II harbor mutations in ataxia telangiectasia and Rad3 related (ATR) or pericentrin (PCNT), leading to disturbed ATR signaling. In this study, we show that a lack of MCPH1 or PCNT results in a loss of Chk1 from centrosomes with subsequently deregulated activation of centrosomal cyclin B–Cdk1
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