Eliminating Recursion from Monadic Datalog Programs on Trees

We study the problem of eliminating recursion from monadic datalog programs on trees with an infinite set of labels. We show that the boundedness problem, i.e., determining whether a datalog program is equivalent to some nonrecursive one is undecidable but the decidability is regained if the descendant relation is disallowed. Under similar restrictions we obtain decidability of the problem of equivalence to a given nonrecursive program. We investigate the connection between these two problems in more detail

Potentially harmful advantage to athletes: a putative connection between UGT2B17 gene deletion polymorphism and renal disorders with prolonged use of anabolic androgenic steroids

ABSTRACT: BACKGROUND AND OBJECTIVE: With prolonged use of anabolic androgenic steroids (AAS), occasional incidents of renal disorders have been observed. Independently, it has also been established that there are considerable inter-individual and inter-ethnic differences, in particular with reference to the uridine diphosphate-glucuronosyltransferase 2B17 (UGT2B17) gene, in metabolising these compounds. This report postulates the association of deletion polymorphism in the UGT2B17 gene with the occurrence of renal disorders on chronic exposure to AAS. PRESENTATION OF THE HYPOTHESIS: The major deactivation and elimination pathway of AASs is through glucuronide conjugation, chiefly catalyzed by the UGT2B17 enzyme, followed by excretion in urine. Excretion of steroids is affected in individuals with a deletion mutation in the UGT2B17 gene. We hypothesize that UGT2B17 deficient individuals are more vulnerable to developing renal disorders with prolonged use of AAS owing to increases in body mass index and possible direct toxic effects of steroids on the kidneys. Elevated serum levels of biologically active steroids due to inadequate elimination can lead to prolonged muscle build up. An increase in body mass index may cause renal injuries due to sustained elevated glomerular pressure and flow rate. TESTING THE HYPOTHESIS: In the absence of controlled clinical trials in humans, observational studies can be carried out. Real time PCR with allelic discrimination should be employed to examine the prevalence of different UGT2B17 genotypes in patients with impaired renal function and AAS abuse. In individuals with the UGT2B17 deletion polymorphism, blood tests, biofluid analyses, urinalysis, and hair analyses following the administration of an anabolic steroid can be used to determine the fate of the substance once in the body. IMPLICATIONS OF THE HYPOTHESIS: If the hypothesis is upheld, anabolic steroid users with a deletion mutation in the UGT2B17 gene may be exposed to an increased risk of developing renal disorders. In the current detecting - sanctioning anti-doping system, athletes motivated by the potential to evade detection owing to their unique genetic make-up could subject themselves to a serious health consequence. More research on AAS metabolism in the presence of UGT2B17 gene deletion is required. Benefit - harm evaluations in therapeutic use of anabolic steroids should also consider this potential link between UGT2B17 gene deletion polymorphism and renal disorders

The Characterization of Salmonella isolated from Pig Meat in Northern Ireland by PFGE and Antibiotic Resistance Profiles

The emergence of antibiotic resistance and especially multiple antibiotic resistance Salmonella has become a concern for the pig industry throughout the EU. Pig herds and pork are considered as principal reservoirs for the multi-resistant Salmonella type Typhimunum DT104, which has acquired resistance to ampicillin, chloramphenicol, streptomycm, sulphonamides and tetracycline. This resistance pattern is also known as ACSSuT. In this study Porcine Salmonella strains were isolated between December 2005 and December 2006. The strains origmated from an abattoir study sampling the \u27oyster\u27 cut. The Antimicrobial Resistance Profiles of all Salmonella isolates in this study were determined by disk diffusion tests. Twelve antibiotics were utilized throughout the profiling procedure Pulsed Field Gel Electrophoresis (PFGE), which is regarded as the Gold Standard for the typmg and strain identification of Salmonella isolates, was used to determine DNA fingerprints of the Salmonella isolates using the restriction enzyme Xbal (Invitrogen) The fragments were then separated by PFGE in a Chef DR II system (Bio-Rad). This enabled comparison of Salmonella isolated in this study

The Physiological, Physical, and Biomechanical Demands of Walking Football:Implications for Exercise Prescription and Future Research in Older Adults

The aim of this investigation was to profile the physiological, physical, and biomechanical responses during walking football. A total of 17 male participants (aged 66 ± 6 years) participated. Heart rate; blood lactate; accelerometer variables (biomechanical load [PlayerLoad.], changes of direction); and rating of perceived exertion were measured. Participants mean percentage of maximum heart rate was 76 ± 6%during the sessions, with rating of perceived exertion across all sessions at 13 ± 2. Blood lactate increased by ∼157% from presession (1.24 ± 0.4 mmol/L) to postsession (3.19 ± 1.7 mmol/L; p ≤ .0005). PlayerLoad. values of 353 ± 67 arbitrary units were observed, as well as ∼100 changes of direction per session. In conclusion, walking football is a moderate- to vigorous-intensity activity. The longitudinal health benefits of walking football remain to be elucidated, particularly on bone health, cardiovascular fitness, and social and mental well-being

Big data and diabetes: the applications of big data for diabetes care now and in the future

Aims: Review the current applications of Big Data in diabetes care and consider the future potential. Methods: Scoping study of the academic literature on Big Data and diabetes care. Results: Healthcare data are being produced at ever-increasing rates, and this information has the potential to transform the provision of diabetes care. Big Data is beginning to have an impact on diabetes care through data research. The use of Big Data for routine clinical care is still a future application. Conclusions: Vast amounts of healthcare data are already being produced, and the key is harnessing these to produce actionable insights. Considerable development work is required to achieve these goals

Novel Superoxide Dismutase Mimetics for Protection against Paraquat-induced Acute Renal Injury

Paraquat-induced nephrotoxicity involves severe renal damage caused by reactive oxygen species (ROS), specifically by increasing superoxide (O2●-) generation in the kidney. While proven to be of benefit in animal models of organ injury involving O2●-, superoxide dismutase (SOD) and superoxide dismutase mimetics (SODm) can suffer problems regarding their bioavailability and toxicity. Since ROS has been incriminated in the pathogenesis of several disease conditions including acute kidney injury, the search for ideal SODm therefore continues unabated. Thus, the current study aims at investigating the therapeutic potential of Manganese (II) complexes of ethylenebis (oxyethylenenitrilo) tetraacetic acid (EGTA) and ethylenebis hydroxyphenylglycine (EHPG), novel SODm, against paraquat-induced nephrotoxicity using an in vivo rodent model. Administration of a single intraperitoneal dose of 10-50 or 100 mg/kg paraquat to male Wistar rats (200-250g) produced acute kidney injury within 48 and 24 hours respectively; as evidenced by a significant increase in serum creatinine, fractional excretion of sodium and a reduction in creatinine clearance. Unlike Mn (II)-EGTA (2mg/kg), Mn (II)-EHPG (4mg/kg) was able to significantly attenuate the acute kidney injury induced by 10-50 mg/kg paraquat. These complexes were not toxic at the doses examined unlike SOD or conventional SODm which can display pro-oxidant actions at higher concentrations. Since the clinical toxicity profiles of EGTA and EHPG are already known, these novel SODm particularly Mn (II)-EHPG could be beneficial in attenuating disease conditions involving ROS generation. Keywords: Acute kidney injury, Oxidative stress, Paraquat, Superoxide anion, Superoxide dismutase mimetic

The Cost of Blindness in the Republic of Ireland 2010-2020

Aims. To estimate the prevalence of blindness in the Republic of Ireland and the associated financial and total economic cost between 2010 and 2020. Methods. Estimates for the prevalence of blindness in the Republic of Ireland were based on blindness registration data from the National Council for the Blind of Ireland. Estimates for the financial and total economic cost of blindness were based on the sum of direct and indirect healthcare and nonhealthcare costs. Results. We estimate that there were 12,995 blind individuals in Ireland in 2010 and in 2020 there will be 17,997. We estimate that the financial and total economic costs of blindness in the Republic of Ireland in 2010 were €276.6 million and €809 million, respectively, and will increase in 2020 to €367 million and €1.1 billion, respectively. Conclusions. Here, ninety-eight percent of the cost of blindness is borne by the Departments of Social Protection and Finance and not by the Department of Health as might initially be expected. Cost of illness studies should play a role in public policy making as they help to quantify the indirect or “hidden” costs of disability and so help to reveal the true cost of illness