PEGASO: LONG DURATION BALLOONS FROM NORTH POLE

In a joint effort, the Italian Space Agency (ASI) and Andoya Rocket Range (ARR) have initiated the development of a European balloon center in Svalbard, Norway that is an ideal location for performing Long Duration Balloon (LDB) flights. After the identification of the launch location several light balloon flights have been performed since 2003. The 2004 campaign utilized a 10000 m³ balloon produced for the program by Aerostar of Sulfur Springs, Texas USA. This flight lasted 40 days and was an excellent test of the small PEGASO payload, developed (for use in Antarctica) by the National Institute of Geophysics and Volcanology (INGV) with the PNRA (Progetto Nazionale di Ricerche in Antartide) sponsorship. This payload uses an IRIDIUM based bi-directional telemetry system. During summer 2005 two flights have been performed using balloons of the same size. They carried an updated telemetry and a scientific payload which analyzed the magnetic field of the Earth. The Institute of Information Science and Technology (ISTI-CNR) team computed predictions of the balloons trajectories, both before and during flights, as well as statistical evaluations of the seasonal flight windows at the beginning of the ASI LDB program. The 2004 and 2005 missions have been defined to investigate the stratospheric winds structure and they tested the possibility for future heavy LDB flights. The Italian scientific community foresees this kind of missions from 2007-2008 campaigns. Next sections, starting from a general overview of the Italian LDB program, give the description of the Pegaso flights and, in particular, the adopted technical solutions for the on-board and ground-based equipments.PublishedVOLTERRA, PISA1.10. TTC - Telerilevamentoope

PEGASO: LONG DURATION BALLOONS FROM NORTH POLE

In a joint effort, the Italian Space Agency (ASI) and Andoya Rocket Range (ARR) have initiated the development of a European balloon center in Svalbard, Norway that is an ideal location for performing Long Duration Balloon (LDB) flights. After the identification of the launch location several light balloon flights have been performed since 2003. The 2004 campaign utilized a 10000 m³ balloon produced for the program by Aerostar of Sulfur Springs, Texas USA. This flight lasted 40 days and was an excellent test of the small PEGASO payload, developed (for use in Antarctica) by the National Institute of Geophysics and Volcanology (INGV) with the PNRA (Progetto Nazionale di Ricerche in Antartide) sponsorship. This payload uses an IRIDIUM based bi-directional telemetry system. During summer 2005 two flights have been performed using balloons of the same size. They carried an updated telemetry and a scientific payload which analyzed the magnetic field of the Earth. The Institute of Information Science and Technology (ISTI-CNR) team computed predictions of the balloons trajectories, both before and during flights, as well as statistical evaluations of the seasonal flight windows at the beginning of the ASI LDB program. The 2004 and 2005 missions have been defined to investigate the stratospheric winds structure and they tested the possibility for future heavy LDB flights. The Italian scientific community foresees this kind of missions from 2007-2008 campaigns. Next sections, starting from a general overview of the Italian LDB program, give the description of the Pegaso flights and, in particular, the adopted technical solutions for the on-board and ground-based equipments

Expression of transforming growth factor beta-1 in gastric cancer and in the gastric mucosa of first-degree relatives of patients with gastric cancer

Transforming growth factors beta (TGF-β) constitute a family of polypeptide growth factors that control cell growth, cell differentiation and migration, as well as the formation of the extracellular matrix. Recent analyses revealed the overexpression of TGF-β1 in human gastric cancers and demonstrated increased cell proliferation in the stomach of patients with gastric cancer and their first-degree relatives. Using human gastric tissues obtained from patients with gastric cancer (n = 19), biopsies from healthy first-degree relatives of gastric cancer patients (n = 18) and healthy individuals (n = 19), we analysed the expression of TGF-β1 using the reverse transcriptase polymerase chain reaction (RT-PCR) and immunohistochemistry. Fifteen of 19 patients with gastric cancer expressed TGF-β1 in the tumour. In 11 of these 15 cases TGF-β1 mRNA was also detectable in the non-tumourous stomach. Interestingly, all but two individuals with a first-degree relative diagnosed with gastric cancer exhibited TGF-β1 expression in either the antrum or corpus biopsy or both. In contrast, only one of 19 individuals without a family history of gastric cancer expressed TGF-β1 in the stomach (P< 0.0001). TGF-β1 expression is detectable in a large proportion of gastric cancers and in the stomach of healthy first-degree relatives of gastric cancer patients. Since individuals without gastric cancers in their family express TGF-β1 only in one of 19 cases, the induction of TGF-β1 expression in first-degree relatives of patients with gastric cancer points to the presence of specific molecular alterations in a subgroup of individuals with an increased risk of developing gastric cancer that may precede the development of gastric cancers. © 2000 Cancer Research Campaig

Association between age at disease onset of anti-neutrophil cytoplasmic antibody-associated vasculitis and clinical presentation and short-term outcomes

Objectives: ANCA-associated vasculitis (AAV) can affect all age groups. We aimed to show that differences in disease presentation and 6 month outcome between younger- A nd older-onset patients are still incompletely understood. Methods: We included patients enrolled in the Diagnostic and Classification Criteria for Primary Systemic Vasculitis (DCVAS) study between October 2010 and January 2017 with a diagnosis of AAV. We divided the population according to age at diagnosis: &lt;65 years or ≥65 years. We adjusted associations for the type of AAV and the type of ANCA (anti-MPO, anti-PR3 or negative). Results: A total of 1338 patients with AAV were included: 66% had disease onset at &lt;65 years of age [female 50%; mean age 48.4 years (s.d. 12.6)] and 34% had disease onset at ≥65 years [female 54%; mean age 73.6 years (s.d. 6)]. ANCA (MPO) positivity was more frequent in the older group (48% vs 27%; P = 0.001). Younger patients had higher rates of musculoskeletal, cutaneous and ENT manifestations compared with older patients. Systemic, neurologic,cardiovascular involvement and worsening renal function were more frequent in the older-onset group. Damage accrual, measured with the Vasculitis Damage Index (VDI), was significantly higher in older patients, 12% of whom had a 6 month VDI ≥5, compared with 7% of younger patients (P = 0.01). Older age was an independent risk factor for early death within 6 months from diagnosis [hazard ratio 2.06 (95% CI 1.07, 3.97); P = 0.03]. Conclusion: Within 6 months of diagnosis of AAV, patients &gt;65 years of age display a different pattern of organ involvement and an increased risk of significant damage and mortality compared with younger patients

An integrative study of the genetic, social and environmental determinants of chronic kidney disease characterized by tubulointerstitial damages in the North Central Region of Sri Lanka

Objectives: Previous investigations on chronic kidney disease of unknown etiology characterized by tubulointerstitial damages (CKDu) in the North Central Region (NCR) of Sri Lanka have supported the involvement of social, environmental and genetic factors in its pathogenesis. Methods: We conducted a social-environmental-and-genetic epidemiology study on a male population in NCR to investi2014gate the genetic and environmental contributors. We recruited 311 case-series patients and 504 control candidates. Of the 504 control candidates, 218 (43%) were eliminated because of the presence of hypertension, proteinuria, high HbA1c, high serum creatinine or high alpha-1 microglobulin in urine. Results and Discussion: None of 18 metals measured (μg/l) in urine, including Cd, As and Pb, showed significantly higher concentrations in cases compared with controls. As speciation results showed that 75-80% of total urinary As was in the form of arsenobetaine, which is non-toxic to humans. None of the metal concentrations in drinking water samples exceeded guideline values. A genome-wide association study (GWAS) was conducted to determine the genetic contributors. The GWAS yielded a genome-wide significant association with CKDu for a single nucleotide polymorphism (SNP; rs6066043; p=5.23 Ã 10-9 in quantitative trait locus analysis; p=3.73 Ã 10-8 in dichotomous analysis) in SLC13A3 (sodium-dependent dicarboxylate transporter member 3). The population attributable fraction and odds ratio for this SNP were 50% and 2.13. Genetic susceptibility was identified as the major risk factor for CKDu. However, 43% of the apparently healthy male Lankapopulation suffers from non-communicable diseases, suggesting their possible influence on CKDu progression