Evidence for the existence of powder sub-populations in micronized materials : Aerodynamic size-fractions of aerosolized powders possess distinct physicochemical properties

This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.Purpose: To investigate the agglomeration behaviour of the fine ( 12.8 µm) particle fractions of salmeterol xinafoate (SX) and fluticasone propionate (FP) by isolating aerodynamic size fractions and characterising their physicochemical and re-dispersal properties. Methods: Aerodynamic fractionation was conducted using the Next Generation Impactor (NGI). Re-crystallized control particles, unfractionated and fractionated materials were characterized for particle size, morphology, crystallinity and surface energy. Re-dispersal of the particles was assessed using dry dispersion laser diffraction and NGI analysis. Results: Aerosolized SX and FP particles deposited in the NGI as agglomerates of consistent particle/agglomerate morphology. SX particles depositing on Stages 3 and 5 had higher total surface energy than unfractionated SX, with Stage 5 particles showing the greatest surface energy heterogeneity. FP fractions had comparable surface energy distributions and bulk crystallinity but differences in surface chemistry. SX fractions demonstrated higher bulk disorder than unfractionated and re-crystallized particles. Upon aerosolization, the fractions differed in their intrinsic emission and dispersion into a fine particle fraction (< 5.0 µm). Conclusions: Micronized powders consisted of sub-populations of particles displaying distinct physicochemical and powder dispersal properties compared to the unfractionated bulk material. This may have implications for the efficiency of inhaled drug deliveryPeer reviewe

Update on the Clinical Utility of Vestibular Evoked Myogenic Potentials

Vestibular-evoked myogenic potentials (VEMPs) supplement the vestibular test battery by providing diagnostic information about otolith organ function. The purpose of this presentation is to provide an update on the clinical use of the cervical VEMP and ocular VEMP as clinical tests of otolith functio

Constraining fine tuning in composite Higgs models with partially composite leptons

Minimal Composite Higgs Models (MCHM) have long provided a solution to the hierarchy problem of the Standard Model, yet suffer from various sources of fine tuning that are becoming increasingly problematic with the lack of new physics observations at the LHC. We develop a new fine tuning measure that accurately counts each contribution to fine tuning (single, double, triple, etc) that can occur in a theory with np parameters, that must reproduce no observables. We then use a novel scanning procedure to perform a comprehensive study of three different two-site, 4D, SO(5) → SO(4) MCHMs with all third generation fermions included, distinguished by the choice of the lepton embeddings. These are the MCHM5 − 5 − 55 − 5 − 5, MCHM14 − 14 − 105 − 5 − 5 and MCHM14 − 1 − 105 − 5 − 5, where MCHMl − τ − νq − t − b has the lepton doublet partner in representation l, tau partner in representation τ, and so on. We find that embedding at least one massive lepton in the symmetric 14 of SO(5) moderately reduces the tuning for the case of low top partner masses (in line with previous results), but that this is balanced against the increased complexity of the model when one properly accounts for all sources of fine tuning. We study both the current relative fine-tuning of each scenario, and the future prospects. Noting that the different scenarios behave differently with respect to future improvements in collider measurements, we find that the MCHM14 − 1 − 105 − 5 − 5 enjoys a relatively low increase in fine tuning even for a future lower bound on the top partner masses of 3.4 TeV (or equivalently a maximum Higgs-fermion or Higgs-gluon coupling deviation of 2%).James Barnard, Daniel Murnane, Martin White, Anthony G. William

Particle size segregation in granular flow in silos

Segregation and layering of alumina in storage silos are investigated, with a view to predicting output quality versus time, given known variations in input quality on emplacement. A variety of experiments were conducted, existing relevant publications were reviewed, and the basis for an algorithm for predicting the effect of withdrawing from a central flowing region, in combination with variations in quality due to geometric, layering and segregation effects, is described in this report

Picosecond ionization dynamics in femtosecond filaments at high pressures

We investigate the plasma dynamics inside a femtosecond-pulse-induced filament generated in an argon gas for a wide range of pressures up to 60 bar. At higher pressures, we observe ionization immediately following a pulse, with up to a threefold increase in the electron density within 30 ps after the filamentary propagation of a femtosecond pulse. Our study suggests that this picosecond evolution can be attributed to collisional ionization including Penning and associative ionizations and electron-impact ionization of excited atoms generated during the pulse. The dominance of excited atoms over ionized atoms at the end of the pulse also indicates an intrapulse inhibition of avalanche ionization. This delayed ionization dynamics provides evidence for diagnosing atomic and molecular excitation and ionization in intense laser interaction with high-pressure gases