364 research outputs found
Carcinoembryonic antigen and glucose phosphate isomerase in a human colonic cancer model (GW-39).
Levels of carcinoembryonic antigen (CEA) and glucose phosphate isomerase (GPI) have been compared in the circulating blood of hamsters bearing intra-muscular grafts of GW-39 human colonic tumour. CEA in the sera of GW-39 tumour-bearing hamsters ranged from 2-6 to 8-4 ng/ml (mean = 4-5 +/- 1-7 ng/ml). GPI in the sera of normal hamsters ranged from 332 to 749 iu/1 (mean = 602 +/- 110 iu/1) while those with 14-week-old intra-muscular grafts of a hamster amelanotic melanoma, (A.Mel.3), or GW-39 human colonic carcinoma had a range of 664 to 1267 iu/1 (mean = 1024 +/- 220 iu/1) and 1430 to 4719 iu/1 (mean = 2065 +/- 601 iu/1) respectively. Thus, the ratio of enzyme activity in GW-39, A.Mel.3, and normal hamsters was 3-4:1-7:1, indicating a significant elevation (P less than 0-01) in animals bearing a human colon carcinoma or a hamster melanoma, with particularly high values obtained in hamsters with GW-39. Sequential determinations of CEA and GPI in a group of hamsters transplanted intra-muscularly with GW-39 tumours revealed that both markers increased proportionately with duration of tumour growth, suggesting that both serum CEA and GPI may be used as measures of tumour growth. The concentration of GPI in GW-39 human colonic carcinoma xenografts was also significantly higher than that measured in normal human colon, primary human colonic cancer, or normal hamster tissues. These results support the view that GPI, in addition to CEA, is a quantitatively increased marker in this tumour model, and is liberated into the circulation in proportion to the increase in tumour mass
Joint Detection and Tracking in Videos with Identification Features
Recent works have shown that combining object detection and tracking tasks,
in the case of video data, results in higher performance for both tasks, but
they require a high frame-rate as a strict requirement for performance. This is
assumption is often violated in real-world applications, when models run on
embedded devices, often at only a few frames per second.
Videos at low frame-rate suffer from large object displacements. Here
re-identification features may support to match large-displaced object
detections, but current joint detection and re-identification formulations
degrade the detector performance, as these two are contrasting tasks. In the
real-world application having separate detector and re-id models is often not
feasible, as both the memory and runtime effectively double.
Towards robust long-term tracking applicable to reduced-computational-power
devices, we propose the first joint optimization of detection, tracking and
re-identification features for videos. Notably, our joint optimization
maintains the detector performance, a typical multi-task challenge. At
inference time, we leverage detections for tracking (tracking-by-detection)
when the objects are visible, detectable and slowly moving in the image. We
leverage instead re-identification features to match objects which disappeared
(e.g. due to occlusion) for several frames or were not tracked due to fast
motion (or low-frame-rate videos). Our proposed method reaches the
state-of-the-art on MOT, it ranks 1st in the UA-DETRAC'18 tracking challenge
among online trackers, and 3rd overall.Comment: Accepted at Image and Vision Computing Journa
A Slice-Based Change Impact Analysis for Regression Test Case Prioritization of Object-Oriented Programs
Macroscopic Dynamics of Multi-Lane Traffic
We present a macroscopic model of mixed multi-lane freeway traffic that can
be easily calibrated to empirical traffic data, as is shown for Dutch highway
data. The model is derived from a gas-kinetic level of description, including
effects of vehicular space requirements and velocity correlations between
successive vehicles. We also give a derivation of the lane-changing rates. The
resulting dynamic velocity equations contain non-local and anisotropic
interaction terms which allow a robust and efficient numerical simulation of
multi-lane traffic. As demonstrated by various examples, this facilitates the
investigation of synchronization patterns among lanes and effects of on-ramps,
off-ramps, lane closures, or accidents.Comment: For related work see
http://www.theo2.physik.uni-stuttgart.de/helbing.htm
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Sex-Specific Effects of a Wartime-Like Radiation Exposure on Cognitive Function.
Evaluating the risk for central nervous system (CNS) effects after whole-body or partial-body irradiation presents challenges due in part to the varied exposure scenarios in the context of occupational, accidental or wartime releases. Risk estimations are further complicated by the fact that robust changes in brain function are unlikely to manifest until significantly late post exposure times. Collectively, the current data regarding CNS radiation risk are conflicting in humans and a survey of the animal model data shows that it is similarly inconsistent. Due to the sparseness of such data, the current study was conducted using male and female mice to evaluate the brain for the delayed effects of a 2 Gy whole-body exposure to c rays starting six months postirradiation. Behavioral testing indicated sex-specific differences in the induction of anxiety-like behaviors and in the ability to abolish fear memories. Molecular analyses showed alterations in post-synaptic protein levels that might affect synaptic plasticity and increased levels of global DNA methylation, suggesting a potential epigenetic mechanism that might contribute to radiation-induced cognitive dysfunction. These data add to the understanding of the CNS response to whole-body irradiation and may lead to improved risk assessment and provide guidance in the development of effective radiation countermeasures to protect military personnel and civilians alike
Thoracic trident pigmentation in Drosophila melanogaster: latitudinal and altitudinal clines in Indian populations
International audienc
Thoracic trident pigmentation in Drosophila melanogaster: latitudinal and altitudinal clines in Indian populations
Modeling and Simulation of Multi-Lane Traffic Flow
A most important aspect in the field of traffic modeling is the simulation of
bottleneck situations. For their realistic description a macroscopic multi-lane
model for uni-directional freeways including acceleration, deceleration,
velocity fluctuations, overtaking and lane-changing maneuvers is systematically
deduced from a gas-kinetic (Boltzmann-like) approach. The resulting equations
contain corrections with respect to previous models. For efficient computer
simulations, a reduced model delineating the coarse-grained temporal behavior
is derived and applied to bottleneck situations.Comment: For related work see
http://www.theo2.physik.uni-stuttgart.de/helbing.htm
Adaptability and AMMI biplot analysis for yield and agronomical traits in scented rice genotypes under diverse production environments
550-562The crucial aspect of the identification of the genotypes adaptable to different production environments (systems) for the thirty-six popular scented rice varieties was countered via adaptability and AMMI biplot analysis. The varieties were evaluated for several agronomical traits (twelve) under four production environments namely, direct-seeded rice (DSR), the system of rice intensification (SRI), chemical-free cultivation (CFC) and transplanted rice (TPR). Among different production environments, SRI was found on the top followed by TPR, CFC and DSR. Genotype × environment interactions were significant for all of the traits. Based on the AMMI biplot technique, Pusa Sugandh 3, HKR -11-509 and Pusa Sugandh 5 were found suitable for grain yield per plant and general adaptation to all the environments
Adaptability and AMMI biplot analysis for yield and agronomical traits in scented rice genotypes under diverse production environments
The crucial aspect of the identification of the genotypes adaptable to different production environments (systems) for the thirty-six popular scented rice varieties was countered via adaptability and AMMI biplot analysis. The varieties were evaluated for several agronomical traits (twelve) under four production environments namely, direct-seeded rice (DSR), the system of rice intensification (SRI), chemical-free cultivation (CFC) and transplanted rice (TPR). Among different production environments, SRI was found on the top followed by TPR, CFC and DSR. Genotype × environment interactions were significant for all of the traits. Based on the AMMI biplot technique, Pusa Sugandh 3, HKR -11-509 and Pusa Sugandh 5 were found suitable for grain yield per plant and general adaptation to all the environments
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