3,331 research outputs found
A STUDY ON STRESS MANAGEMENT IN BHARAT PLASTIC INDUSTRIES, CHENNAI
Stress is a fact of everyday life, weâve all felt it. Sometimes it acts as a negative force. If you experience stress over a prolonged period of time, it could become chronic, till you take some action. About 500 million people worldwide are believed to be suffering from neurotic, stress related and psychological problems. The challenge can, however, be tackled by joint action between life sciences, social sciences, urban planning, Stress is a fact of everyday life, weâve all felt it. Sometimes it acts as a positive force and architecture and politics. This research highlights the causes, effects and management of stress and therefore could be helpful for people who want to learn how to react to stress in a more constructive, proactive way
A STUDY ON TRAINING AND DEVELOPMENTIN SHREE AMBIKA SUGARS LIMITED AT PENNADAM
Training and Development play an important role in the effectiveness of organizations and to the experience of people in work. Training has implications for productivity, health and safety at work and personal development. All organizations employing people need to train and develop their staff. Most organizations are cognizant of this requirement and invest effort and other resources in training and development. Such investment can take the form of employing specialist training and development staff and paying salaries to staff undergoing training and development. Investment in training and development entails obtaining and maintaining space and equipment. This means they are required to give less attention to activities that are obviously more productive in terms of the organizationâs main business. However, investment in training and development is generally regarded as good management practice to maintain appropriate expertise now and in thefuture
THE RELATIONSHIP BETWEEN REWARD SYSTEMS WITH EMPLOYEESâ PERFORMANCE IN INNCON TECHNOLOGY CONSULTING AT CHENNAI
The researcher focuses on the relationship between reward systems with employeesâ performance .The primary data required for this study were collected through structured questionnaire by using simple random sampling and the secondary data were collected from journals and websites. The Collected data were analysed by using statistical tools. The results of this study highlights that there is positive relationship between reward system and employee performance
Distributed Detection over Fading MACs with Multiple Antennas at the Fusion Center
A distributed detection problem over fading Gaussian multiple-access channels
is considered. Sensors observe a phenomenon and transmit their observations to
a fusion center using the amplify and forward scheme. The fusion center has
multiple antennas with different channel models considered between the sensors
and the fusion center, and different cases of channel state information are
assumed at the sensors. The performance is evaluated in terms of the error
exponent for each of these cases, where the effect of multiple antennas at the
fusion center is studied. It is shown that for zero-mean channels between the
sensors and the fusion center when there is no channel information at the
sensors, arbitrarily large gains in the error exponent can be obtained with
sufficient increase in the number of antennas at the fusion center. In stark
contrast, when there is channel information at the sensors, the gain in error
exponent due to having multiple antennas at the fusion center is shown to be no
more than a factor of (8/pi) for Rayleigh fading channels between the sensors
and the fusion center, independent of the number of antennas at the fusion
center, or correlation among noise samples across sensors. Scaling laws for
such gains are also provided when both sensors and antennas are increased
simultaneously. Simple practical schemes and a numerical method using
semidefinite relaxation techniques are presented that utilize the limited
possible gains available. Simulations are used to establish the accuracy of the
results.Comment: 21 pages, 9 figures, submitted to the IEEE Transactions on Signal
Processin
āŠŪāŠđāŠŋāŠēāŠū āŠļāŦāŠĩāŠļāŠđāŠūāŠŊ āŠāŦāŠĨ āŠĶāŦāŠĩāŠūāŠ°āŠū āŠŪāŠđāŠŋāŠēāŠūāŠāŠĻāŠū āŠāŦāŠĩāŠĻāŠŪāŠūāŠ āŠāŠĩāŦāŠē āŠŠāŠ°āŠŋāŠĩāŠ°āŦāŠĪāŠĻ - āŠāŠ āŠ āŠāŦāŠŊāŠūāŠļ
Not availabl
The study of pregnant women with diabetes and screening for mutations related to panel of ten MODY (maturity onset diabetes of the young) genes and polymorphisms in TCF7L2
AIMS AND OBJECTIVES:
Gestational diabetes mellitus (GDM) is believed to result when a genetic predisposition is perpetuated by an increase in insulin resistance during pregnancy. However, in the subjects with GDM in our population, little is known about the genetic basis of MODY and its potential clinical significance. Due to an overlap of clinical features with the more common polygenic type 2 diabetes (T2D) and type 1 diabetes (T1D), the differentiation of patients with maturity onset diabetes of the young (MODY) is a diagnostic challenge. Therefore, we aimed to screen pregnant women with diabetes for a comprehensive panel of ten MODY genes utilizing next generation sequencing (NGS). Further, among the T2D diabetogenic genes, the common variants of TCF7L2 have been shown to be associated with T2D in Asian-Indian population. Our aim was also to investigate whether these TCF7L2 variants associated with T2D would also confer risk for gestational diabetes mellitus.
MATERIAL AND METHODS:
We included 50 south Indian women with diabetes complicating their pregnancy to screen for mutations in a comprehensive panel of ten MODY genes [HNF1A, HNF4A, GCK, PDX1, HNF1B,
NEUROD1, KLF11, CEL, PAX4 and INS]. A novel multiplex polymerase chain reaction (PCR) based target enrichment followed by NGS on the Ion Torrent Personal Genome Machine (PGM). The detected rare variants which were of pathogenic significance were confirmed by Sanger sequencing and genotype phenotype correlation was done. Further, in 166 unrelated women (117 women with gestational diabetes mellitus, 49 ethnically matched non-diabetic control subjects) DNA extraction was done using the Gentrapuregene blood method. The primers were validated by Sanger sequencing (3130 genetic analyzer) and genotyped 3 TCF7L2 polymorphisms (rs7903146, rs12255372 and rs4506565) using TaqMan allelic discrimination assay. The data was analysed using SPSS version 16.0.
RESULTS:
Mutations were identified in 16% (8/50) of the subjects screened. There were two mutations in NEUROD1, two in PDX1, one each in HNF1A, GCK, CEL and INS genes. Seven of these mutations were novel. We further proceeded to identify and confirm the presence of these mutations in the relatives of some of these patients and also the neonates. We have found that the odds ratio (OR) of TCF7L2 polymorphisms rs4506565, rs7903146, rs12255372 for the occurrence of gestational diabetes when compared with controls were 3.75(C.I=0.75-18.53,p=0.08), 1.77 (C.I=0.503-6.263,p=0.37) and 1.40 (C.I=0.24-8.11, P=0.70) respectively.
CONCLUSIONS:
Pregnant women of Asian Indian origin harbor a higher frequency of NEUROD1 and PDX1 mutations, a pattern that differs from the western literature. The NGS platform provides an accurate, rapid and cost effective method for parallelized genetic testing for MODY and hence overcomes the inherent limitation of scalability and cost of Sanger sequencing. The TCF7L2 polymorphism rs4506565 has showed a strong trend towards association with the occurrence of gestational diabetes, when compared to the other two common polymorphisms in TCF7L2 (rs7903146, rs12255372). This is the first preliminary data of TCF7L2 polymorphism associations with gestational diabetes in a south Indian population
Interactive flight control system analysis program
A summary of the development, use, and documentation of the interactive software (DIGIKON IV) for flight control system analyses is presented. A list of recommendations for future development is also included
Active flutter control for flexible vehicles, volume 1
An active flutter control methodology based on linear quadratic gaussian theory and its application to the control of a super critical wing is presented. Results of control surface and sensor position optimization are discussed. Both frequency response matching and residualization used to obtain practical flutter controllers are examined. The development of algorithms and computer programs for flutter modeling and active control design procedures is reported
- âĶ