Civil society organisations, social innovation and health research in Europe

Background. European Union strategies and programmes identify research and innovation as a critical dimension for future economic and social development. While European research policy emphasises support for industry, the health field includes not-for-profit civil society organisations providing social innovation. Yet the perspectives of civil society organisations towards health research in Europe are not well understood. Methods. STEPS (Strengthening Engagement with Public Health Research) was funded by the European Commission’s Science in Society research programme. Within the study, we interviewed by telephone respondents of 13 European health civil society organisations which represented collectively local and national organisations Results. Research was valued positively by the respondents. Health civil society organisations did not seek to do research themselves, but recognised the opportunity of funds in this field and welcomed the possibility of collaborating in research, of using the results from research and of providing input to research agendas. Links between research and users provides knowledge for the public and improves impacts on policy. Research and evaluation can help in demonstrating the benefit of innovative activities, and give support and legitimacy. However, the cultures of, and incentives for, researchers and health civil society organisations are different, and collaboration requires building trust, a shared language, and for the power relations and objectives to match. Conclusions. Health civil society organisations contribute social innovation in organising services and activities such as advocacy that cannot be satisfactorily met by industry. Engaging civil society organisations in research and innovation will strengthen the European Research Area

Bioprocesses

The application of remote sensing techniques to the study of eutrophication in natural waters and the location and characterization of fronts is considered. The specific problem to be studied is examined along with the feasibility and capabability of remote sensing techniques for each application

Spectrophotometric Redshifts. A New Approach to the Reduction of Noisy Spectra and its Application to GRB090423

We have developed a new method, close in philosophy to the photometric redshift technique, which can be applied to spectral data of very low signal-to-noise ratio. Using it we intend to measure redshifts while minimising the dangers posed by the usual extraction techniques. GRB afterglows have generally very simple optical spectra over which the separate effects of absorption and reddening in the GRB host, the intergalactic medium, and our own Galaxy are superimposed. We model all these effects over a series of template afterglow spectra to produce a set of clean spectra that reproduce what would reach our telescope. We also model carefully the effects of the telescope-spectrograph combination and the properties of noise in the data, which are then applied on the template spectra. The final templates are compared to the two-dimensional spectral data, and the basic parameters (redshift, spectral index, Hydrogen absorption column) are estimated using statistical tools. We show how our method works by applying it to our data of the NIR afterglow of GRB090423. At z ~ 8.2, this was the most distant object ever observed. We use the spectrum taken by our team with the Telescopio Nazionale Galileo to derive the GRB redshift and its intrinsic neutral Hydrogen column density. Our best fit yields z=8.4^+0.05/-0.03 and N(HI)<5x10^20 cm^-2, but with a highly non-Gaussian uncertainty including the redshift range z [6.7, 8.5] at the 2-sigma confidence level. Our method will be useful to maximise the recovered information from low-quality spectra, particularly when the set of possible spectra is limited or easily parameterisable while at the same time ensuring an adequate confidence analysis.Comment: 6 pages, 6 figures. Accepted for publication in Astronomy and Astrophysic

Barrier and internal wave contributions to the quantum probability density and flux in light heavy-ion elastic scattering

We investigate the properties of the optical model wave function for light heavy-ion systems where absorption is incomplete, such as $\alpha + ^{40}$Ca and $\alpha + ^{16}$O around 30 MeV incident energy. Strong focusing effects are predicted to occur well inside the nucleus, where the probability density can reach values much higher than that of the incident wave. This focusing is shown to be correlated with the presence at back angles of a strong enhancement in the elastic cross section, the so-called ALAS (anomalous large angle scattering) phenomenon; this is substantiated by calculations of the quantum probability flux and of classical trajectories. To clarify this mechanism, we decompose the scattering wave function and the associated probability flux into their barrier and internal wave contributions within a fully quantal calculation. Finally, a calculation of the divergence of the quantum flux shows that when absorption is incomplete, the focal region gives a sizeable contribution to nonelastic processes.Comment: 16 pages, 15 figures. RevTeX file. To appear in Phys. Rev. C. The figures are only available via anonynous FTP on ftp://umhsp02.umh.ac.be/pub/ftp_pnt/figscat

Buoyancy waves in Pluto's high atmosphere: Implications for stellar occultations

We apply scintillation theory to stellar signal fluctuations in the high-resolution, high signal/noise, dual-wavelength data from the MMT observation of the 2007 March 18 occultation of P445.3 by Pluto. A well-defined high wavenumber cutoff in the fluctuations is consistent with viscous-thermal dissipation of buoyancy waves (internal gravity waves) in Pluto's high atmosphere, and provides strong evidence that the underlying density fluctuations are governed by the gravity-wave dispersion relation.Comment: Accepted 18 June 2009 for publication in Icaru

Models of the ICM with Heating and Cooling: Explaining the Global and Structural X-ray Properties of Clusters

(Abridged) Theoretical models that include only gravitationally-driven processes fail to match the observed mean X-ray properties of clusters. As a result, there has recently been increased interest in models in which either radiative cooling or entropy injection play a central role in mediating the properties of the intracluster medium. Both sets of models give reasonable fits to the mean properties of clusters, but cooling only models result in fractions of cold baryons in excess of observationally established limits and the simplest entropy injection models do not treat the "cooling core" structure present in many clusters and cannot account for entropy profiles revealed by recent X-ray observations. We consider models that marry radiative cooling with entropy injection, and confront model predictions for the global and structural properties of massive clusters with the latest X-ray data. The models successfully and simultaneously reproduce the observed L-T and L-M relations, yield detailed entropy, surface brightness, and temperature profiles in excellent agreement with observations, and predict a cooled gas fraction that is consistent with observational constraints. The model also provides a possible explanation for the significant intrinsic scatter present in the L-T and L-M relations and provides a natural way of distinguishing between clusters classically identified as "cooling flow" clusters and dynamically relaxed "non-cooling flow" clusters. The former correspond to systems that had only mild levels (< 300 keV cm^2) of entropy injection, while the latter are identified as systems that had much higher entropy injection. This is borne out by the entropy profiles derived from Chandra and XMM-Newton.Comment: 20 pages, 15 figures, accepted for publication in the Astrophysical Journa

Effects of negative energy balance on liver gene and protein expression during the early postpartum period and its impacts on dairy cow fertility

End of project reportNegative energy balance (NEB) is a severe metabolic affecting high yielding dairy cows early post partum with both concurrent and latent negative effects on cow fertility as well as on milk production and cow health. The seasonal nature of Irish dairy production necessitates high cow fertility and a compact spring calving pattern in order to maximise grass utilisation. Poor dairy cow reproductive performance currently costs the Irish cattle industry in excess of €400 million annually. High milk yields have been associated with lower reproductive efficiency, and it has been suggested that this effect is probably mediated through its effects on the energy balance of the cow during lactation. The modern high genetic merit dairy cow prioritises nutrient supply towards milk production in early lactation and this demand takes precedence over the provision of optimal conditions for reproduction. In this study we used the bovine Affymetrix 23,000 gene microarray, which contains the most comprehensive set of bovine genes to be assembled and provides a means of investigating the modifying influences of energy balance on liver gene expression. Cows in severe negative energy balance (SNEB) in early lactation showed altered hepatic gene expression in metabolic processes as well as a down regulation of the insulin-like growth factor (IGF) system, where insulin like growth factor-1 (IGF-1), growth hormone receptor variant 1A (GHR1A) and insulin-like growth factor binding protein-acid labile subunit (IGFBP-ALS) were down regulated compared to the cows in the moderate negative energy balance MNEB group, consistent with a five-fold reduction in systemic concentrations of IGF1 in the SNEB group.Cows in SNEB showed elevated expression of key genes involved in the inflammatory response such as interleukin-8 (IL-8). There was a down regulation of genes involved in cellular growth in SNEB cows and moreover a negative regulator of cellular proliferation (HGFIN) was up regulated in SNEB cows, which is likely to compromise adaptation and recovery from NEB. The puma method of analysis revealed that 417 genes were differentially regulated by EB (P<0.05), of these genes 190 were up-regulated while 227 were down-regulated, with 405 genes having known biological functions. From Ingenuity Pathway Analysis (IPA), lipid catabolism was found to be the process most affected by differences in EB status

An alternative derivation of the gravitomagnetic clock effect

The possibility of detecting the gravitomagnetic clock effect using artificial Earth satellites provides the incentive to develop a more intuitive approach to its derivation. We first consider two test electric charges moving on the same circular orbit but in opposite directions in orthogonal electric and magnetic fields and show that the particles take different times in describing a full orbit. The expression for the time difference is completely analogous to that of the general relativistic gravitomagnetic clock effect in the weak-field and slow-motion approximation. The latter is obtained by considering the gravitomagnetic force as a small classical non-central perturbation of the main central Newtonian monopole force. A general expression for the clock effect is given for a spherical orbit with an arbitrary inclination angle. This formula differs from the result of the general relativistic calculations by terms of order c^{-4}.Comment: LaTex2e, 11 pages, 1 figure, IOP macros. Submitted to Classical and Quantum Gravit