1,281 research outputs found
Noncommutative effective theory of vortices in a complex scalar field
We derive a noncommutative theory description for vortex configurations in a
complex field in 2+1 dimensions. We interpret the Magnus force in terms of the
noncommutativity, and obtain some results for the quantum dynamics of the
system of vortices in that context
Quasi-Exact Solvability and the direct approach to invariant subspaces
We propose a more direct approach to constructing differential operators that
preserve polynomial subspaces than the one based on considering elements of the
enveloping algebra of sl(2). This approach is used here to construct new
exactly solvable and quasi-exactly solvable quantum Hamiltonians on the line
which are not Lie-algebraic. It is also applied to generate potentials with
multiple algebraic sectors. We discuss two illustrative examples of these two
applications: an interesting generalization of the Lam\'e potential which
posses four algebraic sectors, and a quasi-exactly solvable deformation of the
Morse potential which is not Lie-algebraic.Comment: 17 pages, 3 figure
Fortaleciendo los h?bitos lectores implementando la literatura infantil como estrategia l?dico pedag?gica para enriquecer las habilidades comunicativas de los ni?os y ni?as del grado preescolar
116 p. Recurso Electr?nicoEl presente proyecto de investigaci?n centra su acci?n en estimular desde edades
tempranas, la lectura y el acercamiento a los libros, como v?a para desarrollar h?bitos
lectores y enriquecer las habilidades comunicativas.
Tiene como objetivo fijar en el ni?o el h?bito de la lectura donde el principal factor es
determinar aquellas posibles causas que propician o desmotivan a los ni?os el deseo de
leer dentro de su mundo, aprender a tener un h?bito lector a temprana edad se ve como
una necesidad en el desarrollo personal y social de cada uno de los ni?os, por eso vemos
necesidad o alternativa de desarrollar estrategias l?dico pedag?gicas como la literatura
infantil, por medio de un proyecto pedag?gico de aula para fortalecer h?bitos lectores,
que le permitan transformar su inteligencia creadora, mejorar sus competencias
comunicativas entre las que aparecen, leer, escribir, hablar y escuchar adem?s permite
acercarlos de manera agradable a los textos.
Conforme con esto, se tiene como referencia la investigaci?n formativa, de igual manera
un modelo de investigaci?n cualitativo con enfoque etnogr?fico, con ?nfasis participativo
y cooperativo, utilizando instrumentos como entrevistas, cuestionarios entre otros dentro
del desarrollo del proyecto. El cual se llev? mediante dos fases, la primera se hizo
mediante la observaci?n de la cual se detect? una problem?tica y la segunda en la cual
se hizo una intervenci?n mediante el proyecto pedag?gico de aula, que dio paso a la
participaci?n activa de toda una comunidad educativa.
Palabras clave: literatura ? lectura ? h?bitos ? cuentos ? habilidades comunicativasThe present research project focuses on stimulating reading and the approaching to
books from early ages, as a way to develop reading habits and enriching communicative
skills.
Its aim is to establish the habit of reading in children, where the main factor is to determine
those possible causes that encourage or discourage children the desire to read within
their world; learning to acquire a reading habit at an early age is seen as a necessity in
the personal and social development of each child, thus, it is seen the necessity or
alternative to implement dynamic-pedagogical strategies such as children's literature,
through a pedagogical classroom project to strengthen reading habits, that allows him to
transform his creative intelligence and to improve his communicative competences such
as, reading, writing, speaking and listening; it also allows to connect them in a pleasant
way to texts.
Accordingly, the research is based on formative research, as well as a qualitative
research model with an ethnographic approach, with a participative and cooperative
emphasis, using instruments such as interviews, questionnaires and others within the
project development. This was carried out in two phases: the first one was done through
the observation in which a problematic was detected and the second one, where an
intervention was made through the classroom pedagogical project, which gave way to the
active participation of an entire educational community.
Keywords: Literature - reading - habits - stories - communicative skill
Impact of footwear and foot deformities in patients with Parkinson?s disease: A case-series study
Background: Parkinson's disease (PD) is a common and complex neurological problem. Gait abnormalities are frequent in PD patients, and this increases the risk of falls. However, little is known about foot deformities and footwear in this vulnerable population. Here we investigate whether patients with PD use an appropriate shoe size and know if they have foot deformities or alterations. Methodology: A study of a series of observational descriptive cases in a convenience sample (n = 53 patients) diagnosed with Parkinson's disease. One trained investigator evaluated foot and ankle health. The footwear and foot measurements were obtained using a Brannock device. Results: The podiatric examination and footwear examination detected a high presence of podiatric pathologies and inappropriate footwear. This has a negative impact on the quality of life of these patients. Conclusions: This research detected an elevated number of people with foot deformities or alterations. Moreover, a high proportion of participants with PD wear inadequate footwear (in length, width, or both)
Does Lithium Deserve a Place in the Treatment Against COVID-19? A Preliminary Observational Study in Six Patients, Case Report
Lithium has shown the capacity to: a) inhibit the replication of several types of viruses, some of which are similar to the SARS-CoV-2 virus, b) increase the immune response by reducing lymphopenia, and c) reduce inflammation by preventing or reducing the cytokine storm. In the present study, we have treated six patients with severe COVID-19 infection with lithium carbonate. We found that lithium carbonate significantly reduced plasma reactive C-Protein levels, increased lymphocyte numbers and decreased the neutrophil-lymphocyte ratio, improving both inflammatory activity and the immune response in these patients. We propose that lithium carbonate may deserve a place in the treatment against COVID-19
Identification of a novel synthetic lethal vulnerability in non-small cell lung cancer by co-targeting TMPRSS4 and DDR1
Finding novel targets in non-small cell lung cancer (NSCLC) is highly needed and identification of synthetic lethality between two genes is a new approach to target NSCLC. We previously found that TMPRSS4 promotes NSCLC growth and constitutes a prognostic biomarker. Here, through large-scale analyses across 5 public databases we identified consistent co-expression between TMPRSS4 and DDR1. Similar to TMPRSS4, DDR1 promoter was hypomethylated in NSCLC in 3 independent cohorts and hypomethylation was an independent prognostic factor of disease-free survival. Treatment with 5-azacitidine increased DDR1 levels in cell lines, suggesting an epigenetic regulation. Cells lacking TMPRSS4 were highly sensitive to the cytotoxic effect of the DDR1 inhibitor dasatinib. TMPRSS4/DDR1 double knock-down (KD) cells, but not single KD cells suffered a G0/G1 cell cycle arrest with loss of E2F1 and cyclins A and B, increased p21 levels and a larger number of cells in apoptosis. Moreover, double KD cells were highly sensitized to cisplatin, which caused massive apoptosis (~40%). In vivo studies demonstrated tumor regression in double KD-injected mice. In conclusion, we have identified a novel vulnerability in NSCLC resulting from a synthetic lethal interaction between DDR1 and TMPRSS4
ZNF577 Methylation Levels in Leukocytes From Women With Breast Cancer Is Modulated by Adiposity, Menopausal State, and the Mediterranean Diet
The methylation levels of ZNF577 in breast tumors has been previously identified as a possible epigenetic mark of breast cancer associated with obesity. The aim of the current study was to investigate differences in methylation levels of ZNF577 depending on obesity, menopausal state and dietary pattern in blood leukocytes, a non-invasive sample. The methylation levels of ZNF577 of two CpG sites (CpGs) located in promoter and island previously identified as differentially methylated according to adiposity and menopausal state by 450 k array (cg10635122, cg03562414) were evaluated by pyrosequencing in DNA from the blood leukocytes of breast cancer patients [n = 90; n = 64 (71.1%) overweight/obesity and n = 26 (28.9%) normal-weight] and paired tumor tissue biopsies (n = 8 breast cancer patients with obesity; n = 3/5 premenopausal/postmenopausal women). Differences in methylation levels were evaluated at each CpGs individually and at the mean of the two evaluated CpGs. Adherence to the Mediterranean diet was evaluated using the MEDAS-validated questionnaire, and the consumption of food groups of interest was also evaluated using the recommended intakes of the Sociedad Espanola de Nutricion Comunitaria. The methylation levels of ZNF577 were correlated between paired leukocytes and breast tumor biopsies (r = 0.62; p = 0.001). Moreover, higher methylation was found in leukocytes from patients with obesity (p = 0.002) and postmenopausal patients (p = 0.022) than patients with normal-weight or premenopausal, respectively. After adjusting for the body mass index and age, higher levels of ZNF577 methylation were also found in women with greater adherence to the Mediterranean diet (p = 0.017) or specific foods. Relevantly, the methylation levels of ZNF577 showed a good ability for fish consumption detection [area under the ROC curve (AUC) = 0.72; p = 0.016]. In conclusion, the association between methylation of ZNF577 and adiposity, menopausal state, and adherence to the Mediterranean diet can be detected in the blood leukocytes. The results guarantee the need of performing further studies in longer longitudinal cohorts in order to elucidate the role of ZNF577 methylation in the association between breast cancer, adiposity and dietary patterns
Improved personalized survival prediction of patients with diffuse large B-cell Lymphoma using gene expression profiling
BACKGROUND: Thirty to forty percent of patients with Diffuse Large B-cell Lymphoma (DLBCL) have an adverse clinical evolution. The increased understanding of DLBCL biology has shed light on the clinical evolution of this pathology, leading to the discovery of prognostic factors based on gene expression data, genomic rearrangements and mutational subgroups. Nevertheless, additional efforts are needed in order to enable survival predictions at the patient level. In this study we investigated new machine learning-based models of survival using transcriptomic and clinical data. METHODS: Gene expression profiling (GEP) of in 2 different publicly available retrospective DLBCL cohorts were analyzed. Cox regression and unsupervised clustering were performed in order to identify probes associated with overall survival on the largest cohort. Random forests were created to model survival using combinations of GEP data, COO classification and clinical information. Cross-validation was used to compare model results in the training set, and Harrel's concordance index (c-index) was used to assess model's predictability. Results were validated in an independent test set. RESULTS: Two hundred thirty-three and sixty-four patients were included in the training and test set, respectively. Initially we derived and validated a 4-gene expression clusterization that was independently associated with lower survival in 20% of patients. This pattern included the following genes: TNFRSF9, BIRC3, BCL2L1 and G3BP2. Thereafter, we applied machine-learning models to predict survival. A set of 102 genes was highly predictive of disease outcome, outperforming available clinical information and COO classification. The final best model integrated clinical information, COO classification, 4-gene-based clusterization and the expression levels of 50 individual genes (training set c-index, 0.8404, test set c-index, 0.7942). CONCLUSION: Our results indicate that DLBCL survival models based on the application of machine learning algorithms to gene expression and clinical data can largely outperform other important prognostic variables such as disease stage and COO. Head-to-head comparisons with other risk stratification models are needed to compare its usefulness
Oscillatons revisited
In this paper, we study some interesting properties of a spherically
symmetric oscillating soliton star made of a real time-dependent scalar field
which is called an oscillaton. The known final configuration of an oscillaton
consists of a stationary stage in which the scalar field and the metric
coefficients oscillate in time if the scalar potential is quadratic. The
differential equations that arise in the simplest approximation, that of
coherent scalar oscillations, are presented for a quadratic scalar potential.
This allows us to take a closer look at the interesting properties of these
oscillating objects. The leading terms of the solutions considering a quartic
and a cosh scalar potentials are worked in the so called stationary limit
procedure. This procedure reveals the form in which oscillatons and boson stars
may be related and useful information about oscillatons is obtained from the
known results of boson stars. Oscillatons could compete with boson stars as
interesting astrophysical objects, since they would be predicted by scalar
field dark matter models.Comment: 10 pages REVTeX, 10 eps figures. Updated files to match version
published in Classical and Quantum Gravit
Phenomenological Determination of the Beauty Meson Decay Parameter and the CP-Violating Angle
We fit the -matrix to all recent data with the following free
parameters: three mixing angles, the CP-violating angle in the Maiani
parametrisation, the top quark mass , and the product f_B{\cal
B}_{\B}^{1/2}, where is the -meson decay parameter and {\cal
B}_{\B} is the bag parameter. Our fits span a contiguous region in the
(f_B{\cal B}_{\B}^{1/2},\ \cos\delta)--plane, limited by 0.117\lsim f_B{\cal
B}_{\B}^{1/2}/{\rm GeV}\lsim 0.231 and --0.95 \lsim \lsim
0.70. The parameters f_B{\cal B}_{\B}^{1/2} and are strongly
positively correlated.Comment: 9 pages + 1 figure available upon request, HU-TFT-94-3
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