Alzheimer’s disease-associated peptide Aβ₄₂ mobilizes ER Ca²⁺ via InsP₃R-dependent and -independent mechanisms

Dysregulation of Ca2+ homeostasis is considered to contribute to the toxic action of the Alzheimer’s Disease (AD) associated Amyloid β-peptide (Aβ). Ca2+ fluxes across the plasma membrane and release from intracellular stores have both been reported to underlie the Ca2+ fluxes induced by Aβ42. Here, we investigated the contribution of Ca2+ release from the endoplasmic reticulum (ER) to the effects of Aβ42 upon Ca2+ homeostasis and the mechanism by which Aβ42 elicited these effects. Consistent with previous reports, application of soluble oligomeric forms of Aβ42 exhibited Ca2+ mobilizing properties. The Aβ42-stimulated Ca2+ signals persisted in the absence of extracellular Ca2+ indicating a significant contribution of Ca2+ release from the ER Ca2+ store to the generation of these signals. Moreover, inositol 1,4,5-trisphosphate (InsP3) signaling contributed to Aβ42-stimulated Ca2+ release. The Ca2+ mobilizing effect of Aβ42 was also observed when applied to permeabilized cells deficient in InsP3 receptors revealing an additional direct effect of internalized Aβ42 upon the ER, and a mechanism for induction of toxicity by intracellular Aβ42

Depression in Belgian first-year university students: A longitudinal study of self-definition, interpersonal relatedness, mentalizing, and integration

Despite evidence of increasing prevalence of depression in university students, few studies investigated how depression evolves over the first months at university. We investigate severity of depression among first-year university students during their first semester at university, and whether it was associated with impairments in personality, mentalizing (or reflective functioning) and social and academic integration. Participants in this two-wave prospective study were 377 Belgian first-year students in 2018 and 2019. Results showed that maladaptive interpersonal relatedness and self-definition at the start of the first semester (T1) were prospectively associated with increases in the prevalence and severity of depression at the end of the semester (T2). Uncertainty, but not certainty, with regard to mentalizing was positively associated with severity of depression at T2 and mediated the association between personality dimensions and severity of depression. The implications of these findings for depression prevention and intervention strategies in first-year university students are discussed

Undetected scars? Self-criticism, attachment, and romantic relationships among otherwise well-functioning childhood sexual abuse survivors

Background: Studies have consistently demonstrated the negative impact of childhood sexual abuse (CSA) on intimate relationships. The majority of studies have focused on revictimization in at-risk or clinical samples, with very few addressing the impact of CSA on otherwise well-functioning adults and even fewer investigating the psychological mechanisms involved. To fill this gap, this study focuses on the effect of CSA on “normative” (nonviolent) romantic relationships in otherwise well-functioning young women, and the mediating role of personality dimension self-criticism and attachment in this regard. Specifically, we investigate whether self-criticism and attachment avoidance mediate the relationship between CSA and romantic relationship satisfaction, while also examining the potential reciprocal associations between these variables. Method: The hypothesized mediation model was examined in a 2-wave, 6-month, cross-lagged longitudinal design, using structural equation modeling. Participants were 59 well-functioning (psychologically, socially, occupationally) young women drawn from an earlier study that purposefully oversampled for CSA survivors. For the purpose of the current study, data from women who had been either sexually abused by a familiar perpetrator (n = 30) or had no history of sexual trauma (n = 29) were included. Results: Consistent with expectations, self-criticism mediated the association between CSA and romantic relationship satisfaction over time. In addition, a scarring effect of romantic relationship satisfaction on attachment avoidance was demonstrated. Conclusion: Findings suggest that CSA may lead to elevated levels of self-criticism, which in turn may be linked with reduced satisfaction in romantic relationships, setting in motion a vicious cycle involving relationship satisfaction and attachment avoidance

The Effect of Childhood Emotional Maltreatment on Romantic Relationships in Young Adulthood: A Double Mediation Model Involving Self-Criticism and Attachment

Objective: Despite growing recognition of the importance of childhood emotional maltreatment (CEM) on the development of psychopathology, very few studies have addressed its impact on adult romantic relationship functioning, particularly among otherwise relatively well-functioning individuals. In an attempt to further elucidate the mechanism underlying the negative impact of CEM on romantic relationships, we tested an integrative mediational model linking CEM to romantic relationships through the impact of CEM on the development of self-criticism and adult attachment. Recent work in this context suggests that while self-criticism concerns broad cognitive-affective schemas related to achievement and failure, attachment avoidance assesses the expression of these broad schemas in close relationships (Luyten & Blatt, 2011; Sibley & Overall, 2008, 2010). Method: This hypothesized mediational model was examined in a sample of young adult undergraduates (N = 99, 85 female), using structural equation modeling. Results: The mediational model was in large part supported. Attachment avoidance, but not attachment anxiety, fully accounted for the mediating role of self-criticism in the relationship between CEM and romantic relationship satisfaction, even when controlling for the potential role of concurrent levels of posttraumatic stress disorder severity. Conclusions: Understanding the long-term psychological dynamics related to CEM and identifying mediating vulnerability factors—self-criticism and attachment avoidance—might have implications for both the assessment and treatment of individuals with a history of CEM, particularly as effective interventions to address self-criticism and attachment issues are available

The LuckyCam Survey for Very Low Mass Binaries II: 13 new M4.5-M6.0 Binaries

We present results from a high-angular-resolution survey of 78 very low mass (VLM) binary systems with 6.0 = 0.15 arcsec/yr. 21 VLM binaries were detected, 13 of them new discoveries. The new binary systems range in separation between 0.18 arcsec and 1.3 arcsec. The distance-corrected binary fraction is 13.5% (+6.5%/-4%), in agreement with previous results. 9 of the new binary systems have orbital radii > 10 AU, including a new wide VLM binary with 27 AU projected orbital separation. One of the new systems forms two components of a 2300 AU separation triple system. We find that the orbital radius distribution of the binaries with V-K < 6.5 in this survey appears to be different from that of redder (lower-mass) objects, suggesting a possible rapid change in the orbital radius distribution at around the M5 spectral type. The target sample was also selected to investigate X-ray activity among VLM binaries. There is no detectable correlation between excess X-Ray emission and the frequency and binary properties of the VLM systems.Comment: 11 pages, 8 figures. Submitted to MNRA

Ethical climate in a Belgian psychiatric inpatient setting: relation with burnout and engagement in psychiatric nurses

Research suggests a relation between the ethical climate – that is, the organisational conditions and practices that affect the way ethical issues with regard to patient care are discussed and decided - and job satisfaction of nurses. Yet no study to date has investigated the relationship between ethical climate and job satisfaction in psychiatric nurses. This study aimed to address this critical gap in our knowledge by investigating the relationships among ethical climate and features of both burnout and engagement based on the Job Demands-Resources Model (JD - R model) in a large cross-sectional study of 265 nurses working in a large psychiatric inpatient hospital in Flanders, Belgium. Correlational and multiple hierarchical regression analyses were used to investigate the relationship between ethical climate, burnout and engagement. In addition, based on the JD-R model, we also investigated whether engagement mediated the relationship between ethical climate on the one hand and job satisfaction and turnover intention on the other and whether ethical climate moderated the relationship between emotional burden and burnout. Results showed that a positive ethical climate was related to lower levels of emotional exhaustion and distancing and higher levels of engagement and job satisfaction. Furthermore, although ethical climate did not buffer against the effects of emotional burden on burnout, higher levels of engagement explained in part the relationship between ethical climate and job satisfaction

Consequences of divorce-based father absence during childhood for young adult well-being and romantic relationships

Objective: This research explores the implications of father absence due to divorce on young adults' well‐being and romantic relationships. Background: Studies have demonstrated the negative implications of father absence, a common consequence of divorce, on children's development. However, previous research has not systematically compared complete versus partial father absence. Method: Young adults who, as children, experienced complete (n = 38) or partial (n = 41) father absence were compared with 40 participants in a father‐presence control group. Results: Compared with those in the control group, young adults in the partial father‐absence group reported higher psychopathology and maternal overprotection, and lower maternal care, romantic intimacy, commitment, and passion. Under elevated maternal care, the partial‐absence group reported lower dyadic adjustment and consolidated sense of identity. Participants in the complete‐absence group reported higher self‐criticism and maternal overprotection and lower maternal care than controls. Conclusion: Partial father absence might have particularly pernicious consequences for young adults' well‐being. Implications: Clinical and public policy implications are discussed

Mentalizing in mothers and children with type 1 diabetes

Studies suggest that the relationship between psychosocial well-being and type 1 diabetes (T1D) is bidirectional, with T1D typically having a negative influence on psychological functioning, which in turn negatively affects the course of T1D. Here, we investigate the potential role of the capacity for mentalizing, or reflective functioning, in children and their mothers in diabetes control. We tested differences in mentalizing as assessed by the Reflective Functioning Scale in two groups of mother–son dyads with good (GDC) versus poor (PDC) diabetes control. Fifty-five boys (8–12 years old) and their mothers were recruited from the Juvenile Diabetes Foundation in Santiago, Chile. The mothers were interviewed with the Parental Development Interview and the children with the Child Attachment Interview, and both were scored for reflective functioning by using the Reflective Functioning Scale. Self-report measures of stress and diabetes outcomes were completed by the mothers and children, and levels of glycated hemoglobin (HbA1c) were assessed as an index of diabetes control. The results showed that both maternal and child reflective functioning were higher in the GDC than the PDC group and were negatively correlated with HbA1c in the total sample. Our findings suggest an important role for mentalizing in diabetes outcomes, but further prospective research is needed