Near-capacity dirty-paper code design : a source-channel coding approach

This paper examines near-capacity dirty-paper code designs based on source-channel coding. We first point out that the performance loss in signal-to-noise ratio (SNR) in our code designs can be broken into the sum of the packing loss from channel coding and a modulo loss, which is a function of the granular loss from source coding and the target dirty-paper coding rate (or SNR). We then examine practical designs by combining trellis-coded quantization (TCQ) with both systematic and nonsystematic irregular repeat-accumulate (IRA) codes. Like previous approaches, we exploit the extrinsic information transfer (EXIT) chart technique for capacity-approaching IRA code design; but unlike previous approaches, we emphasize the role of strong source coding to achieve as much granular gain as possible using TCQ. Instead of systematic doping, we employ two relatively shifted TCQ codebooks, where the shift is optimized (via tuning the EXIT charts) to facilitate the IRA code design. Our designs synergistically combine TCQ with IRA codes so that they work together as well as they do individually. By bringing together TCQ (the best quantizer from the source coding community) and EXIT chart-based IRA code designs (the best from the channel coding community), we are able to approach the theoretical limit of dirty-paper coding. For example, at 0.25 bit per symbol (b/s), our best code design (with 2048-state TCQ) performs only 0.630 dB away from the Shannon capacity

Nested turbo codes for the costa problem

Driven by applications in data-hiding, MIMO broadcast channel coding, precoding for interference cancellation, and transmitter cooperation in wireless networks, Costa coding has lately become a very active research area. In this paper, we first offer code design guidelines in terms of source- channel coding for algebraic binning. We then address practical code design based on nested lattice codes and propose nested turbo codes using turbo-like trellis-coded quantization (TCQ) for source coding and turbo trellis-coded modulation (TTCM) for channel coding. Compared to TCQ, turbo-like TCQ offers structural similarity between the source and channel coding components, leading to more efficient nesting with TTCM and better source coding performance. Due to the difference in effective dimensionality between turbo-like TCQ and TTCM, there is a performance tradeoff between these two components when they are nested together, meaning that the performance of turbo-like TCQ worsens as the TTCM code becomes stronger and vice versa. Optimization of this performance tradeoff leads to our code design that outperforms existing TCQ/TCM and TCQ/TTCM constructions and exhibits a gap of 0.94, 1.42 and 2.65 dB to the Costa capacity at 2.0, 1.0, and 0.5 bits/sample, respectively

“New public Management reforms, an empirical study of human resources critical factors, in the context of the Greek Public sector”

This work is an endeavour on the subject of the Critical Success Factors imposed by Human Resources, in the process of reforms, under the context of New Public Management, particularly, as this applies in the Greek Public Sector and more specifically in the cases of ISO implementation. The fundamental issues it attempts to elucidate are the Human Resources policies that must be applied, so that employees become an integral element for the successful implementation of any introduced reforms. Many scholars have pointed out the gap in literature regarding the effect of New Public Management (NPM) reforms on the human factor. Moreover, in the current Greek reality, in the context of the economic recession and the debt crisis, where public administration reforms are mandatory, the thorough examination of the vital issues, pertaining to Human Resources, consists a major priority. The qualitative research method applied with the employees of the reformed organisations has further aspired to ponder and determine what really matters during the transformational process from the employees’ point of view. The conclusions we have reached underpin the importance of Human Resources motivational factors in the reform process, taking into consideration that the employee is the catalyst for any change effort. Some of those factors were found to be also part of the ISO concept per se, thus, their implementation would boost the employees’ morale, while others must be carefully analysed, planned and implemented by all the stakeholders to further facilitate the change process. We have to bear in mind that, especially under the current dire economic environment, quality reforms could be a challenge, as they combine fiscal discipline and at the same time aspire to increase the employees’ and citizens’ satisfaction. This study goes further to suggest that, the implementation of ISO reforms could help all the participants, provided that the decision makers take into serious consideration the Critical Success Factors outlined herewith, that have been extracted from a survey conducted pertinent to our research. This study focused on the reforms/ISO process as implemented by the Intermediate Managing Authority of the Ionian Islands. Further research on the implications from the implementation of NMP doctrines on Human Resources should be conducted in other Greek governmental organisations, in order to reaffirm the results and possibly enhance the suggested model. Conclusively, our ultimate target is to assist decision makers and encourage them to utilise the arguments depicted, towards the successful implementation of NPM doctrines

Statistical mechanical aspects of joint source-channel coding

An MN-Gallager Code over Galois fields, $q$, based on the Dynamical Block Posterior probabilities (DBP) for messages with a given set of autocorrelations is presented with the following main results: (a) for a binary symmetric channel the threshold, $f_c$, is extrapolated for infinite messages using the scaling relation for the median convergence time, $t_{med} \propto 1/(f_c-f)$; (b) a degradation in the threshold is observed as the correlations are enhanced; (c) for a given set of autocorrelations the performance is enhanced as $q$ is increased; (d) the efficiency of the DBP joint source-channel coding is slightly better than the standard gzip compression method; (e) for a given entropy, the performance of the DBP algorithm is a function of the decay of the correlation function over large distances.Comment: 6 page

Evaluating the Effects of Match-Induced Fatigue on Landing Ability; the Case of the Basketball Game

International Journal of Exercise Science 14(6): 768-778, 2021. This paper examines the effect of match–induced fatigue on lower limb biomechanics, in the case of a basketball game. For this purpose, sixteen male basketball athletes, ages 18 to 22, performed a jump-landing task prior and post a recreational basketball game. The Landing Error Scoring System (LESS) was used to examine the biomechanics of landing. The Vertical jump (VJ) and the Borg Rating of Perceived Exertion (RPE) scale pre- and post-game were employed to assess the level of fatigue induced by the basketball game. In order to compare pre and post measurements, t-tests for dependent samples were used. The performance of the VJ test post-game was found to be significantly lower (t (15) = 3.83, p = 0.002) showing a large effect (Cohen’s d = 0.9) compared to pre-game measurements. Further, the LESS scores were significantly (t (15) = 2.33, p = 0.034) higher post-game with a medium effect (d = 0.5). The differences in LESS scores were due to errors in the landing technique which is bound to be influenced by biomechanics. Moreover, the Borg RPE scale was found to be significantly higher (t (15) = 10.77, p \u3c 0.001) post-game showing a very large effect (d =2.6). It is important to note, that these significant differences occurred with a merely medium level of fatigue (6.6 ± 0.3 pre-game vs 11.9 ± 1.0 post-game). The results of this study would be of great benefit to sports science teams and coaches for formulating effective strategies to improve athletes’ performance and reduce the likelihood of injury

Two Distinct Mechanisms Govern RpoS-mediated Repression of Tick-phase Genes During Mammalian Host Adaptation by Borrelia burgdorferi, the Lyme Disease Spirochete

The alternative sigma factor RpoS plays a key role modulating gene expression in Borrelia burgdorferi, the Lyme disease spirochete, by transcribing mammalian host-phase genes and repressing sigma(70)-dependent genes required within the arthropod vector. To identify cis regulatory elements involved in RpoS-dependent repression, we analyzed green fluorescent protein (GFP) transcriptional reporters containing portions of the upstream regions of the prototypical tick-phase genes ospAB, the glp operon, and bba74 As RpoS-mediated repression occurs only following mammalian host adaptation, strains containing the reporters were grown in dialysis membrane chambers (DMCs) implanted into the peritoneal cavities of rats. Wild-type spirochetes harboring ospAB- and glp-gfp constructs containing only the minimal (-35/-10) sigma(70) promoter elements had significantly lower expression in DMCs relative to growth in vitro at 37 degrees C; no reduction in expression occurred in a DMC-cultivated RpoS mutant harboring these constructs. In contrast, RpoS-mediated repression of bba74 required a stretch of DNA located between -165 and -82 relative to its transcriptional start site. Electrophoretic mobility shift assays employing extracts of DMC-cultivated B. burgdorferi produced a gel shift, whereas extracts from RpoS mutant spirochetes did not. Collectively, these data demonstrate that RpoS-mediated repression of tick-phase borrelial genes occurs by at least two distinct mechanisms. One (e.g., ospAB and the glp operon) involves primarily sequence elements near the core promoter, while the other (e.g., bba74) involves an RpoS-induced transacting repressor. Our results provide a genetic framework for further dissection of the essential gatekeeper role of RpoS throughout the B. burgdorferi enzootic cycle.IMPORTANCEBorrelia burgdorferi, the Lyme disease spirochete, modulates gene expression to adapt to the distinctive environments of its mammalian host and arthropod vector during its enzootic cycle. The alternative sigma factor RpoS has been referred to as a gatekeeper due to its central role in regulating the reciprocal expression of mammalian host- and tick-phase genes. While RpoS-dependent transcription has been studied extensively, little is known regarding the mechanism(s) of RpoS-mediated repression. We employed a combination of green fluorescent protein transcriptional reporters along with an in vivo model to define cis regulatory sequences responsible for RpoS-mediated repression of prototypical tick-phase genes. Repression of ospAB and the glp operon requires only sequences near their core promoters, whereas modulation of bba74 expression involves a putative RpoS-dependent repressor that binds upstream of the core promoter. Thus, Lyme disease spirochetes employ at least two different RpoS-dependent mechanisms to repress tick-phase genes within the mammal

Lack of effects of pioglitazone on cardiac function in patients with type 2 diabetes and evidence of left ventricular diastolic dysfunction: a tissue doppler imaging study

<p>Abstract</p> <p>Background</p> <p>Thiazolidinediones, used for the treatment of patients with type 2 diabetes mellitus (DM2), are associated with an increased incidence of heart failure. We sought to investigate the effects of pioglitazone on novel echocardiographic indices of left ventricular (LV) diastolic function in DM2 patients with LV diastolic dysfunction (LVDD).</p> <p>Methods</p> <p>Eighty-eight asymptomatic DM2 patients on metformin and/or sulfonylureas, aged 64.5 ± 7.7 years, without known cardiovascular disease, with normal LV systolic function and evidence of LVDD were randomly assigned to pioglitazone 30 mg/day (n = 42) or an increase in dose of other oral agents (n = 39) for 6 months. All patients underwent transthoracic conventional and Tissue Doppler Imaging echocardiography at baseline and follow-up. The primary end-point was change in early diastolic velocity of the mitral annulus (E').</p> <p>Results</p> <p>Improvement of glycaemic control was similar in the 2 groups. A significant difference (p < 0.05) between the 2 groups was found in the treatment-induced changes in fasting insulin, the insulin resistance index HOMA, HDL cholesterol, triglycerides, diastolic blood pressure (all in favor of pioglitazone) and in body weight (increase with pioglitazone). No significant changes were observed in any echocardiographic parameter in either group and did not differ between groups (p = NS for all). E' increased non-significantly and to a similar extent in both groups (p = NS).</p> <p>Conclusions</p> <p>In asymptomatic DM2 patients with LVDD, the addition of pioglitazone to oral conventional treatment for 6 months does not induce any adverse or favorable changes in LV diastolic or systolic function despite improvements in glycaemic control, insulin sensitivity, lipid profile, and blood pressure.</p

Biodiversity of Borrelia burgdorferi Strains in Tissues of Lyme Disease Patients

Plant and animal biodiversity are essential to ecosystem health and can provide benefits to humans ranging from aesthetics to maintaining air quality. Although the importance of biodiversity to ecology and conservation biology is obvious, such measures have not been applied to strains of an invasive bacterium found in human tissues during infection. In this study, we compared the strain biodiversity of Borrelia burgdorferi found in tick populations with that found in skin, blood, synovial fluid or cerebrospinal fluid of Lyme disease patients. The biodiversity of B. burgdorferi strains is significantly greater in tick populations than in the skin of patients with erythema migrans. In turn, strains from skin are significantly more diverse than strains at any of the disseminated sites. The cerebrospinal fluid of patients with neurologic Lyme disease harbored the least pathogen biodiversity. These results suggest that human tissues act as niches that can allow entry to or maintain only a subset of the total pathogen population. These data help to explain prior clinical observations on the natural history of B. burgdorferi infection and raise several questions that may help to direct future research to better understand the pathogenesis of this infection

Central Role of the Holliday Junction Helicase RuvAB in vlsE Recombination and Infectivity of Borrelia burgdorferi

Antigenic variation plays a vital role in the pathogenesis of many infectious bacteria and protozoa including Borrelia burgdorferi, the causative agent of Lyme disease. VlsE, a 35 kDa surface-exposed lipoprotein, undergoes antigenic variation during B. burgdorferi infection of mammalian hosts, and is believed to be a critical mechanism by which the spirochetes evade immune clearance. Random, segmental recombination between the expressed vlsE gene and adjacent vls silent cassettes generates a large number of different VlsE variants within the infected host. Although the occurrence and importance of vlsE sequence variation is well established, little is known about the biological mechanism of vlsE recombination. To identify factors important in antigenic variation and vlsE recombination, we screened transposon mutants of genes known to be involved in DNA recombination and repair for their effects on infectivity and vlsE recombination. Several mutants, including those in BB0023 (ruvA), BB0022 (ruvB), BB0797 (mutS), and BB0098 (mutS-II), showed reduced infectivity in immunocompetent C3H/HeN mice. Mutants in ruvA and ruvB exhibited greatly reduced rates of vlsE recombination in C3H/HeN mice, as determined by restriction fragment polymorphism (RFLP) screening and DNA sequence analysis. In severe combined immunodeficiency (C3H/scid) mice, the ruvA mutant retained full infectivity; however, all recovered clones retained the ‘parental’ vlsE sequence, consistent with low rates of vlsE recombination. These results suggest that the reduced infectivity of ruvA and ruvB mutants is the result of ineffective vlsE recombination and underscores the important role that vlsE recombination plays in immune evasion. Based on functional studies in other organisms, the RuvAB complex of B. burgdorferi may promote branch migration of Holliday junctions during vlsE recombination. Our findings are consistent with those in the accompanying article by Dresser et al., and together these studies provide the first examples of trans-acting factors involved in vlsE recombination