First record of the sawfly family Xyelidae (Hymenoptera) from Malta

Xyela cf. altenhoferi Blank, 2013 is recorded from Buskett (Malta). Its host is Pinus halepensis. This is the first species of the sawfly family Xyelidae to be found in the Maltese Islands.peer-reviewe

Sawflies (Hymenoptera: Symphyta) of the Parc Natural de s’Albufera de Mallorca

[eng]Eleven sawfly species are recorded from the largest wetland area in the Balearic Islands. Seven of these species are recorded for the first time in the archipelago, with one of them, Janus luteipes, being an addition to the recorded fauna of the Iberian Region.[cat]S’han registrat onze símfits a la zona humida més gran de les Illes Balears. Set d’aquestes espècies han estat primera cita per a l’arxipèlag, essent una d’elles, Janus luteipes, també una addició per a la fauna de la regió Ibèrica

Simulations of snow distribution and hydrology in a mountain basin

We applied a version of the Regional Hydro‐Ecologic Simulation System (RHESSys) that implements snow redistribution, elevation partitioning, and wind‐driven sublimation to Loch Vale Watershed (LVWS), an alpine‐subalpine Rocky Mountain catchment where snow accumulation and ablation dominate the hydrologic cycle. We compared simulated discharge to measured discharge and the simulated snow distribution to photogrammetrically rectified aerial (remotely sensed) images. Snow redistribution was governed by a topographic similarity index. We subdivided each hillslope into elevation bands that had homogeneous climate extrapolated from observed climate. We created a distributed wind speed field that was used in conjunction with daily measured wind speeds to estimate sublimation. Modeling snow redistribution was critical to estimating the timing and magnitude of discharge. Incorporating elevation partitioning improved estimated timing of discharge but did not improve patterns of snow cover since wind was the dominant controller of areal snow patterns. Simulating wind‐driven sublimation was necessary to predict moisture losses

The tail of the Jurassic fish Leedsichthys problematicus (Osteichthyes: Actinopterygii) collected by Alfred Nicholson Leeds - an example of the importance of historical records in palaeontology

The specimen of the tail of <i>Leedsichthys problematicus</i>, now in The Natural History Museum, London, was one of the most spectacular fossil vertebrates from the Oxford Clay Formation of Peterborough, but as an isolated find it shares no bones in common with the holotype of the genus and species. However, a letter from Alfred Nicholson Leeds and related documents cast valuable new light on the excavation of the tail, indicating that it was discovered with cranial bones, gill-rakers, and two pectoral fins, thereby including elements that can potentially be compared with those of the holotype. The documents also clearly indicate that The Natural History Museum's specimen is not part of the same individual as any other numbered specimen of <i>Leedsichthys</i> as had been speculated on other occasions. The maximum size of the animal represented by The Natural History Museum's specimen was possibly around 9 metres, considerably less than previous estimates of up to 27.6 metres for <i>Leedsichthys</i>. Historical documentary evidence should therefore be rigorously checked both when studying historical specimens in science, and in preparing text for museum display labels

Non-invasive assessment of murine PD-L1 levels in syngeneic tumor models by nuclear imaging with nanobody tracers

Blockade of the inhibitory PD-1/PD-L1 immune checkpoint axis is a promising cancer treatment. Nonetheless, a significant number of patients and malignancies do not respond to this therapy. To develop a screen for response to PD-1/PD-L1 inhibition, it is critical to develop a non-invasive tool to accurately assess dynamic immune checkpoint expression. Here we evaluated non-invasive SPECT/CT imaging of PD-L1 expression, in murine tumor models with varying PD-L1 expression, using high affinity PD-L1-specific nanobodies (Nbs). We generated and characterized 37 Nbs recognizing mouse PD-L1. Among those, four Nbs C3, C7, E2 and E4 were selected and evaluated for preclinical imaging of PD-L1 in syngeneic mice. We performed SPECT/CT imaging in wild type versus PD-L1 knock-out mice, using Technetium-99m (99mTc) labeled Nbs. Nb C3 and E2 showed specific antigen binding and beneficial biodistribution. Through the use of CRISPR/Cas9 PD-L1 knock-out TC-1 lung epithelial cell lines, we demonstrate that SPECT/CT imaging using Nb C3 and E2 identifies PD-L1 expressing tumors, but not PD-L1 non-expressing tumors, thereby confirming the diagnostic potential of the selected Nbs. In conclusion, these data show that Nbs C3 and E2 can be used to non-invasively image PD-L1 levels in the tumor, with the strength of the signal correlating with PD-L1 levels. These findings warrant further research into the use of Nbs as a tool to image inhibitory signals in the tumor environment

Is there evidence for export-led adoption of ISO 14001? A review of the literature using meta-regression

Does the export orientation of a firm affect the likelihood that it adopts an environmental management certification? We use meta-regression methods to analyze systematically the corpus of published research on export-led adoption of the largest and most prominent certification, ISO 14001. We show that the explanatory variables authors choose to include in their models reflect the tenets of stakeholder and institutional theories. We also find that the literature suffers from substantial publication bias but that, once this is accounted for appropriately, a genuine effect remains. The evidence from 20 years of published studies taken as a whole is that export does incentivize the adoption of the standard as often hypothesized by proponents of voluntary approaches and self-regulation

Self-Affirmation Improves Problem-Solving under Stress

High levels of acute and chronic stress are known to impair problem-solving and creativity on a broad range of tasks. Despite this evidence, we know little about protective factors for mitigating the deleterious effects of stress on problem-solving. Building on previous research showing that self-affirmation can buffer stress, we tested whether an experimental manipulation of self-affirmation improves problem-solving performance in chronically stressed participants. Eighty undergraduates indicated their perceived chronic stress over the previous month and were randomly assigned to either a self-affirmation or control condition. They then completed 30 difficult remote associate problem-solving items under time pressure in front of an evaluator. Results showed that self-affirmation improved problem-solving performance in underperforming chronically stressed individuals. This research suggests a novel means for boosting problem-solving under stress and may have important implications for understanding how self-affirmation boosts academic achievement in school settings. © 2013 Creswell et al