Exoplanetary atmosphere target selection in the era of comparative planetology

The large number of new planets expected from wide-area transit surveys means that follow-up transmission spectroscopy studies of their atmospheres will be limited by the availability of telescope assets. We argue that telescopes covering a broad range of apertures will be required, with even 1m-class instruments providing a potentially important contribution. Survey strategies that employ automated target selection will enable robust population studies. As part of such a strategy, we propose a decision metric to pair the best target to the most suitable telescope, and demonstrate its effectiveness even when only primary transit observables are available. Transmission spectroscopy target selection need not therefore be impeded by the bottle-neck of requiring prior follow-up observations to determine the planet mass. The decision metric can be easily deployed within a distributed heterogeneous network of telescopes equipped to undertake either broadband photometry or spectroscopy. We show how the metric can be used either to optimise the observing strategy for a given telescope (e.g. choice of filter) or to enable the selection of the best telescope to optimise the overall sample size. Our decision metric can also provide the basis for a selection function to help evaluate the statistical completeness of follow-up transmission spectroscopy datasets. Finally, we validate our metric by comparing its ranked set of targets against lists of planets that have had their atmospheres successfully probed, and against some existing prioritised exoplanet lists.Comment: 20 pages, 16 figures, 3 tables. Revision 3, accepted by MNRAS. Improvements include always using planetary masses where available and reliable, treatment for sky backgrounds and out-of-transit noise and a use case for defocused photometr

Is the Large Magellanic Cloud a Large Microlensing Cloud?

An expression is provided for the self-lensing optical depth of the thin LMC disk surrounded by a shroud of stars at larger scale heights. The formula is written in terms of the vertical velocity dispersion of the thin disk population. If tidal forcing causes 1-5 % of the disk mass to have a height larger than 6 kpc and 10-15 % to have a height above 3 kpc, then the self-lensing optical depth of the LMC is $0.7 - 1.9 \times 10^{-7}$, which is within the observational uncertainties. The shroud may be composed of bright stars provided they are not in stellar hydrodynamical equilibrium. Alternatively, the shroud may be built from low mass stars or compact objects, though then the self-lensing optical depths are overestimates of the true optical depth by a factor of roughly 3. The distributions of timescales of the events and their spatial variation across the face of the LMC disk offer possibilities of identifying the dominant lens population. In propitious circumstances, an experiment lifetime of less than 5 years is sufficient to decide between the competing claims of Milky Way halos and LMC lenses. However, LMC disks can sometimes mimic the microlensing properties of Galactic halos for many years and then decades of survey work are needed. In this case observations of parallax or binary caustic events offer the best hope for current experiments to deduce the lens population. The difficult models to distinguish are Milky Way halos in which the lens fraction is low (< 10 %) and fattened LMC disks composed of lenses with a typical mass of low luminosity stars or greater. A next-generation wide-area microlensing survey, such as the proposed ``SuperMACHO'' experiment, will be able to distinguish even these difficult models with just a year or two of data.Comment: 25 pages, 4 figures, The Astrophysical Journal (in press

Theory of pixel lensing towards M31 I: the density contribution and mass of MACHOs

POINT-AGAPE is an Anglo-French collaboration which is employing the Isaac Newton Telescope (INT) to conduct a pixel-lensing survey towards M31. In this paper we investigate what we can learn from pixel-lensing observables about the MACHO mass and fractional contribution in M31 and the Galaxy for the case of spherically-symmetric near-isothermal haloes. We employ detailed pixel-lensing simulations which include many of the factors which affect the observables. For a maximum MACHO halo we predict an event rate in V of up to 100 per season for M31 and 40 per season for the Galaxy. However, the Einstein radius crossing time is generally not measurable and the observed full-width half-maximum duration provides only a weak tracer of lens mass. Nonetheless, we find that the near-far asymmetry in the spatial distribution of M31 MACHOs provides significant information on their mass and density contribution. We present a likelihood estimator for measuring the fractional contribution and mass of both M31 and Galaxy MACHOs which permits an unbiased determination to be made of MACHO parameters, even from data-sets strongly contaminated by variable stars. If M31 does not have a significant population of MACHOs in the mass range 0.001-1 Solar masses strong limits will result from the first season of INT observations. Simulations based on currently favoured density and mass values indicate that, after three seasons, the M31 MACHO parameters should be constrained to within a factor four uncertainty in halo fraction and an order of magnitude uncertainty in mass (90% confidence). Interesting constraints on Galaxy MACHOs may also be possible. For a campaign lasting ten years, comparable to the lifetime of current LMC surveys, reliable estimates of MACHO parameters in both galaxies should be possible. (Abridged)Comment: 21 pages, 14 figures. Submitted to MNRA

PHYTOCHEMICAL SCREENING AND ANALYSIS POLYPHENOLIC ANTIOXIDANT ACTIVITY OF METHANOLIC EXTRACT OF WHITE DRAGON FRUIT (Hylocereus undatus)

White dragon fruit is a well known and widely used herbal medicine, especially in Asia, which contains several interesting bioactive constituents and possesses health promoting properties. The aim of this study was to analyze for the bioactive compounds, evaluate total phenolic contents and antioxidant capacities of methanolic extract of white dragon fruit. The antioxidant activity was determined by the 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity assay. Total phenolic content were determined by Folin-Ciocalteu method. Phytochemical screening of the white dragon fruit showed the presence of triterpenoid, alkaloid, flavonoid and saponin. The extract exhibited strong antioxidant activity with IC50 of 193 μg/mL, and total phenolic content of 246 μg/mL in 1 Kg dry extract

Gamma ray astronomy and baryonic dark matter

Recently, Dixon et al. have re-analyzed the EGRET data, finding a statistically significant diffuse $\gamma$-ray emission from the galactic halo. We show that this emission can naturally be explained within a previously-proposed model for baryonic dark matter, in which $\gamma$-rays are produced through the interaction of high-energy cosmic-ray protons with cold $H_2$ clouds clumped into dark clusters - these dark clusters supposedly populate the outer galactic halo and can show up in microlensing observations. Our estimate for the halo $\gamma$-ray flux turns out to be in remarkably good agreement with the discovery by Dixon et al. We also address future prospects to test our predictions.Comment: 9 pages, 1 figure included, to appear in ApJ 510, L103 (1999

Genome-Wide CRISPR Screen Reveals Autophagy Disruption as the Convergence Mechanism That Regulates the NRF2 Transcription Factor

The nuclear factor (erythroid 2)-like 2 (NRF2 or NFE2L2) transcription factor regulates the expression of many genes that are critical in maintaining cellular homeostasis. Its deregulation has been implicated in many diseases, including cancer and metabolic and neurodegenerative diseases. While several mechanisms by which NRF2 can be activated have gradually been identified over time, a more complete regulatory network of NRF2 is still lacking. Here we show through a genome-wide clustered regularly interspaced short palindromic repeat (CRISPR) screen that a total of 273 genes, when knocked out, will lead to sustained NRF2 activation. Pathway analysis revealed a significant overrepresentation of genes (18 of the 273 genes) involved in autophagy. Molecular validation of a subset of the enriched genes identified 8 high-confidence genes that negatively regulate NRF2 activity irrespective of cell type: ATG12, ATG7, GOSR1, IFT172, NRXN2, RAB6A, VPS37A, and the well-known negative regulator of NRF2, KEAP1 Of these, ATG12, ATG7, KEAP1, and VPS37A are known to be involved in autophagic processes. Our results present a comprehensive list of NRF2 negative regulators and reveal an intimate link between autophagy and NRF2 regulation.National Institute of Environmental Health Sciences [R21ES027920]; National Science Foundation Graduate Research Fellowship Program [DGE-1746060]; [R01CA226920]; [R01DK109555]; [R01ES026845]; [P42ES004940]; [P30ES006694]6 month embargo; accepted manuscript posted online 22 April 2019This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]

EUCLID : Dark Universe Probe and Microlensing planet Hunter

There is a remarkable synergy between requirements for Dark Energy probes by cosmic shear measurements and planet hunting by microlensing. Employing weak and strong gravitational lensing to trace and detect the distribution of matter on cosmic and Galactic scales, but as well as to the very small scales of exoplanets is a unique meeting point from cosmology to exoplanets. It will use gravity as the tool to explore the full range of masses not accessible by any other means. EUCLID is a 1.2m telescope with optical and IR wide field imagers and slitless spectroscopy, proposed to ESA Cosmic Vision to probe for Dark Energy, Baryonic acoustic oscillation, galaxy evolution, and an exoplanet hunt via microlensing. A 3 months microlensing program will already efficiently probe for planets down to the mass of Mars at the snow line, for free floating terrestrial or gaseous planets and habitable super Earth. A 12+ months survey would give a census on habitable Earth planets around solar like stars. This is the perfect complement to the statistics that will be provided by the KEPLER satellite, and these missions combined will provide a full census of extrasolar planets from hot, warm, habitable, frozen to free floating.Comment: 6 pages 3 figures, invited talk in Pathways towards habitable planets, Barcelona, Sept 200

Reliability of the Myotonometer for Assessment of Posterior Shoulder Tightness

BACKGROUND/PURPOSE: The Myotonometer® is an electronic tissue compliance meter that has been used to quantify the compliance of soft tissues. The Myotonometer® may be a valuable tool to measure the effectiveness of interventions commonly used to increase tissue compliance in individuals with posterior shoulder tightness (PST). Limited data exist on reliability and responsiveness of the Myotonometer® for assessment of soft tissues about the shoulder; therefore, the purpose of this study is to determine the intra- and inter-session reliability and responsiveness of the Myotonometer® in measuring tissue compliance of the posterior shoulder musculature in asymptomatic subjects with PST. METHODS: Fifteen asymptomatic subjects with unilateral shoulder range of motion deficits attended two measurement sessions to assess the compliance of the tissues overlying the posterior deltoid, infraspinatus, and teres musculature. Analyses of reliability and responsiveness were conducted using intra-class correlation coefficients (ICCs) and the determination of minimal detectible change (MDC). RESULTS: Intra-session ICC values ranged from 0.69 to 0.91 for all muscles with MDC never exceeding 1.0 mm. Inter-session ICC values were best for the posterior deltoid, which averaged 0.82, compared to the infraspinatus and the teres complex, which averaged 0.42 and 0.5 respectively. Inter-session MDC ranged from 0.55 to 1.20 mm across all muscles. CONCLUSIONS: Clinicians can reliably detect relatively small changes in tissue compliance within a single treatment session utilizing the Myotonometer®. The Myotonometer® can reliably detect changes between sessions for tissues overlying the posterior deltoid; however, observed change in the infraspinatus and teres musculature must be above 1 mm to achieve meaningful change and account for decreased inter-session reliability. LEVEL OF EVIDENCE: 3