Model ingredients and peak mass production in heavy-ion collisions

We simulate the central reactions of $^{20}$Ne+$^{20}$Ne, $^{40}$Ar+$^{45}$Sc, $^{58}$Ni+$^{58}$Ni, $^{86}$Kr+$^{93}$Nb, $^{129}$Xe+$^{118}$Sn, $^{86}$Kr+$^{197}$Au, and $^{197}$Au+$^{197}$Au at different incident energies for different equations of state, different binary cross sections and different widths of Gaussians. A rise-and-fall behavior of the multiplicity of intermediate mass fragments (IMFs) is observed. The system size dependence of peak center-of-mass energy E$_{c.m.} ^{max}$ and peak IMF multiplicity $^{max}$ is also studied, where it is observed that E$_{c.m.}^{max}$ follows a linear behavior and $^{max}$ shows a power-law dependence. A comparison between two clusterization methods, the minimum spanning tree and the minimum spanning tree method with binding energy check (MSTB), is also made. We find that the MSTB method reduces the $^{max}$, especially in heavy systems. The power-law dependence is also observed for fragments of different sizes at E$_{c.m.} ^{max}$ and the power-law parameter $\tau$ is found to be close to unity in all cases except A$^{max}$.Comment: 6 Figures, 7 page

Socio-demographics, Oral Health Behavior, and Physical Activity: Factors in Caries Experience Among 19–59 Years Old Adults in a Malaysian Population

Dental caries is one of the common diseases that are attributed by many factors. Many from the adult population are afflicted with dental caries. This study aimed to determine the predictors of developing dental caries among adults. Three hundred and thirty four adults participated in this study. Information gathered includes their socio-demographic backgrounds, oral health behaviour, physical activity level, body mass index, body fat percentages, visceral fat level, and dental missing filled extracted teeth (DMFX) index. All standard protocols were observed and DMFX was examined using the World Health Organization (WHO) criteria. Prevalence of dental caries was 87.4%, inclusive of 61.3% of female respondents with caries experience. Most of the study participants were overweight. Only the consumption of high sugar food (p=0.03) was found to be connected between dental caries and oral health behaviours. Regression analysis (p<0.001) showed that older age (p<0.001), regular visits to dental clinic per year (p=0.012), lower education level (p=0.025), and lower physical activity (p=0.008) were significant factors in developing dental caries among this study population. Older aged adults, frequent appointment with the dentist, lower education in oral health, and lower physical activity were possible factors for dental caries presence

Solitude, Silence, and the Training of Psychotherapists: A Preliminary Study

The spiritual disciplines of silence and solitude have long been practiced within the contemplative Christian tradition as a means of character transformation and experiencing God. Do these disciplines affect the use of silence in psychotherapy for Christian clinicians in a graduate training program? Nineteen graduate students in clinical psychology were assigned to a wait-list control condition or a training program involving the disciplines of solitude and silence, and the groups were reversed after the ftrst cohort completed the spiritual disciplines training. One group, which was coincidentally comprised of more introverted individuals, demonstrated a striking increase in the number of silent periods and total duration of silence during simulated psychotherapy sessions during the period of training. The other group, more extraverted in nature, did not show significant changes in therapeutic silence during the training. These results cause us to pose research questions regarding the interaction of personality characteristics and spiritual disciplines in training Christian psychotherapists

Comparison of TCGA and GENIE genomic datasets for the detection of clinically actionable alterations in breast cancer.

Whole exome sequencing (WES), targeted gene panel sequencing and single nucleotide polymorphism (SNP) arrays are increasingly used for the identification of actionable alterations that are critical to cancer care. Here, we compared The Cancer Genome Atlas (TCGA) and the Genomics Evidence Neoplasia Information Exchange (GENIE) breast cancer genomic datasets (array and next generation sequencing (NGS) data) in detecting genomic alterations in clinically relevant genes. We performed an in silico analysis to determine the concordance in the frequencies of actionable mutations and copy number alterations/aberrations (CNAs) in the two most common breast cancer histologies, invasive lobular and invasive ductal carcinoma. We found that targeted sequencing identified a larger number of mutational hotspots and clinically significant amplifications that would have been missed by WES and SNP arrays in many actionable genes such as PIK3CA, EGFR, AKT3, FGFR1, ERBB2, ERBB3 and ESR1. The striking differences between the number of mutational hotspots and CNAs generated from these platforms highlight a number of factors that should be considered in the interpretation of array and NGS-based genomic data for precision medicine. Targeted panel sequencing was preferable to WES to define the full spectrum of somatic mutations present in a tumor

Broken Time Reversal Symmetry and Superconducting States in the Cuprates

Recently, Kaminski et al. have reported that time reversal symmetry is broken in the pseudogap phase in the high temperature superconducting material Bi_2Sr_2CaCu_2O_{2+\delta} (Bi-2212). Here we examine the role of translationally invariant broken time reversal states on d_{x^2-y^2} superconductors. In particular, we determine the change in the superconducting order parameter structure. We find that the broken time reversal pseudogap state that is consistent with the experiment of Kaminski et al., gives rise to a novel mixed singlet-triplet pairing d+ip phase. This d+ip state is shown to give rise to a helical superconducting phase. Consequences of this d+ip state on Josephson experiments are discussed.Comment: 5 pages, 1 figur

Single-Molecule Analysis of i-motif Within Self-Assembled DNA Duplexes and Nanocircles

The cytosine (C)-rich sequences that can fold into tetraplex structures known as i-motif are prevalent in genomic DNA. Recent studies of i-motif–forming sequences have shown increasing evidence of their roles in gene regulation. However, most of these studies have been performed in short single-stranded oligonucleotides, far from the intracellular environment. In cells, i-motif–forming sequences are flanked by DNA duplexes and packed in the genome. Therefore, exploring the conformational dynamics and kinetics of i-motif under such topologically constrained environments is highly relevant in predicting their biological roles. Using single-molecule fluorescence analysis of self-assembled DNA duplexes and nanocircles, we show that the topological environments play a key role on i-motif stability and dynamics. While the human telomere sequence (C3TAA)3C3 assumes i-motif structure at pH 5.5 regardless of topological constraint, it undergoes conformational dynamics among unfolded, partially folded and fully folded states at pH 6.5. The lifetimes of i-motif and the partially folded state at pH 6.5 were determined to be 6 ± 2 and 31 ± 11 s, respectively. Consistent with the partially folded state observed in fluorescence analysis, interrogation of current versus time traces obtained from nanopore analysis at pH 6.5 shows long-lived shallow blockades with a mean lifetime of 25 ± 6 s. Such lifetimes are sufficient for the i-motif and partially folded states to interact with proteins to modulate cellular processes