Superconductivity-Induced Anderson Localisation

We have studied the effect of a random superconducting order parameter on the localization of quasi-particles, by numerical finite size scaling of the Bogoliubov-de Gennes tight-binding Hamiltonian. Anderson localization is obtained in d=2 and a mobility edge where the states localize is observed in d=3. The critical behavior and localization exponent are universal within error bars both for real and complex random order parameter. Experimentally these results imply a suppression of the electronic contribution to thermal transport from states above the bulk energy gap.Comment: 4 pages, revtex file, 3 postscript figure

Targeted DamID in C. elegans reveals a direct role for LIN-22 and NHR-25 in antagonising the epidermal stem cell fate

Transcription factors are key players in gene networks controlling cell fate specification during development. In multicellular organisms, they often display complex patterns of expression and binding to their targets, hence tissue-specificity is required in the characterisation of transcription factor-target interactions. We introduce here Targeted DamID (TaDa) as a method for tissue-specific transcription factor target identification in intact C. elegans animals. We employ TaDa to recover targets in the epidermis for two key transcription factors, the HES1 homologue LIN-22 and the NR5A1/2 nuclear hormone receptor NHR-25. We demonstrate a direct link between LIN-22 and the Wnt signalling pathway through repression of the Frizzled receptor lin-17. We also find a direct role for NHR-25 in promoting cell differentiation via repressing the expression of stem cell-promoting GATA factors. Our results expand our understanding of the epidermal gene network and highlight the potential of TaDa to dissect the architecture of tissue-specific gene regulatory networks

Distributed Sum-Rate Maximization of Cellular Communications with Multiple Reconfigurable Intelligent Surfaces

The technology of Reconfigurable Intelligent Surfaces (RISs) has lately attracted considerable interest from both academia and industry as a low-cost solution for coverage extension and signal propagation control. In this paper, we study the downlink of a multi-cell wideband communication system comprising single-antenna Base Stations (BSs) and their associated single-antenna users, as well as multiple passive RISs. We assume that each BS controls a separate RIS and performs Orthogonal Frequency Division Multiplexing (OFDM) transmissions. Differently from various previous works where the RIS unit elements are considered as frequency-flat phase shifters, we model them as Lorentzian resonators and present a joint design of the BSs' power allocation, as well as the phase profiles of the multiple RISs, targeting the sum-rate maximization of the multi-cell system. We formulate a challenging distributed nonconvex optimization problem, which is solved via successive concave approximation. The distributed implementation of the proposed design is discussed, and the presented simulation results showcase the interplay of the various system parameters on the sum rate, verifying the performance boosting role of RISs.Comment: 5 pages, 1 figure. Presented in IEEE SPAWC 202

© Author(s) 2009. This work is distributed under the Creative Commons Attribution 3.0 License. Natural Hazards

Relationship between lightning and model simulated microphysical parameters over the central and eastern Mediterranea

Diagnosis and outcome of oesophageal Crohn's disease

BACKGROUND AND AIMS: Crohn's disease (CD) can involve any part of the gastrointestinal tract. We aimed to characterize clinical, endoscopic, histologic features and treatment outcomes of CD patients with oesophageal involvement. METHODS: We collected cases through a retrospective multicentre European Crohn's and Colitis Organisation CONFER [COllaborative Network For Exceptionally Rare case reports] project. Clinical data were recorded in a standardized case report form. RESULTS: A total of 40 patients were reported [22 males, mean (±SD, range) age at oesophageal CD diagnosis: 25 (±13.3, 10-71) years and mean time of follow-up: 67 (±68.1, 3-240) months]. Oesophageal involvement was established at CD diagnosis in 26 patients (65%) and during follow-up in 14. CD was exclusively located in the oesophagus in 2 patients. Thirteen patients (32.2%) were asymptomatic at oesophageal disease diagnosis. Oesophageal strictures were present in 5 patients and fistulizing oesophageal disease in one. Eight patients exhibited granulomas on biopsies. Proton-pump inhibitors (PPIs) were administered in 37 patients (92.5%). Three patients underwent endoscopic dilation for symptomatic strictures and none oesophageal-related surgery. Diagnosis in pre-established CD resulted in treatment modifications in 9/14 patients. Clinical remission of oesophageal disease was seen in 33/40 patients (82.5%) after a mean time of 7 (±5.6, 1-18) months. Follow-up endoscopy was performed in 29/40 patients and 26/29 (89.7%) achieved mucosal healing. CONCLUSION: In this case series the endoscopic and histologic characteristics of isolated oesophageal CD were similar to those reported in other sites of involvement. Treatment was primarily conservative, with PPIs administered in the majority of patients and modifications in pre-existing IBD-related therapy occurring in two thirds of them. Clinical and endoscopic remission was achieved in more than 80% of the patients.info:eu-repo/semantics/publishedVersio

Efficacy and Safety of Oral Factor XIa Inhibitors in Stroke Prevention: A Systematic Review and Meta-Analysis

Anticoagulation; Factor Xia inhibitors; Ischemic strokeAnticoagulació; Inhibidors del factor Xia; Ictus isquèmicAnticoagulación; Inhibidores del factor Xia; Ictus isquémicoIntroduction: Despite preventive measures, stroke rates remain high in the primary and secondary prevention settings. Factor XIa inhibition may offer a novel, safe and effective antithrombotic option for stroke prevention. Methods: We conducted a systematic review and meta-analysis including all available randomized controlled clinical trials (RCTs) that investigated the efficacy and safety of factor XIa inhibitors versus controls in primary or secondary stroke prevention. The primary efficacy and safety outcomes of interest were symptomatic ischemic stroke (IS) and the composite of major bleeding and clinically relevant non-major bleeding. Results: Four phase II dose-finding RCTs were included, comprising a total of 4732 patients treated with factor XIa inhibitors versus 1798 controls. Treatment with factor XIa inhibitors did not reduce the risk of IS compared to controls (RR: 0.89; 95% CI: 0.67–1.17). The composite of symptomatic IS and covert infarcts on brain MRI (RR: 1.01; 95% CI: 0.87–1.18), the composite of symptomatic IS and transient ischemic attack (TIA; RR: 0.78; 95% CI: 0.61–1.01), and the composite of major adverse cardiovascular events (RR: 1.07; 95% CI: 0.87–1.31) did not differ between the treatment groups. Treatment with factor XIa inhibitors did not increase the risk of the composite of major bleeding and clinically relevant non-major bleeding (RR: 1.19; 95% CI: 0.65–2.16), major bleeding alone (RR: 1.19; 95% CI: 0.64–2.22), intracranial bleeding (RR: 0.91; 95% CI: 0.26–3.19) or all-cause mortality (RR: 1.21; 95% CI: 0.77–1.90). Conclusion: This meta-analysis provides reassuring evidence regarding the safety of factor XIa inhibitors. These findings, coupled with potential signals of efficacy in reducing IS (and TIA), underscore the importance of ongoing phase III RCTs for providing definitive data regarding the effect of factor XIa inhibition on stroke prevention

Relationship between lightning and model simulated microphysical parameters over the central and eastern Mediterranean

Aubert Marcel. Lejeaux (Jeanne). Sculpture religieuse (Bibliothèque catholique des sciences religieuses), 1934. In: Bulletin Monumental, tome 93, n°2, année 1934. pp. 267-268

Binomial level densities

It is shown that nuclear level densities in a finite space are described by a continuous binomial function, determined by the first three moments of the Hamiltonian, and the dimensionality of the underlying vector space. Experimental values for $^{55}$Mn, $^{56}$Fe, and $^{60}$Ni are very well reproduced by the binomial form, which turns out to be almost perfectly approximated by Bethe's formula with backshift. A proof is given that binomial densities reproduce the low moments of Hamiltonians of any rank: A strong form of the famous central limit result of Mon and French. Conditions under which the proof may be extended to the full spectrum are examined.Comment: 4 pages 2 figures Second version (previous not totally superseeded