The geopolitics of civil war intervention

The regional interests of third party interveners are critical determinants of intervention in civil war. Foreign policymakers often tout the importance of regional stability when justifying their intervention decisions, as civil wars have shown a distinct tendency to be geographically contagious. Third parties observe these regional diffusion properties and consider a war's likelihood of infecting its regional context when deciding whether or not to become involved. As a third party becomes increasingly able to contain a civil war's hostilities from spreading into a region of foreign policy value to the potential intervener, intervention to contain the conflict becomes increasingly likely. I draw on theories of war diffusion and intervention to construct a model of intervention decision making, focusing on third party interests in the containment of conflict hostilities. Hypotheses derived from this model are then tested on the population of potential interveners for all civil wars in the post{World War II period. The empirical results support the theoretical arguments put forth in the intervention model, as third parties are shown to intervene in confiicts that threaten the third party's regional stability interests. In addition, the relative effectiveness of intervention as a tool for containing civil war hostilities is empirically tested. The findings indicate that interventions increase the likelihood of regional contagion in the short{term, but decrease its likelihood in the longterm. The theoretical and empirical advances of this dissertation represent the first study to directly address how the contagious properties of civil conflicts affect intervention phenomena

Asymmetric three-beam binary optic grating

Binary and diffractive optical components are finding many applications in optical systems and integrated optical devices. A recent application required the development of a two-dimensional diffraction grating to perform an asymmetric, three-beam fanout. In this paper, techniques are presented for the design of arbitrary fanout grating devices. Modeling and optimization processes are demonstrated for the three-beam grating. The counter-intuitive results of the initial design are discussed, and experimental data verifying performance are presented

Two-color holography concept (T-CHI)

The Material Processing in the Space Program of NASA-MSFC was active in developing numerous optical techniques for the characterization of fluids in the vicinity of various materials during crystallization and/or solidification. Two-color holographic interferometry demonstrates that temperature and concentration separation in transparent (T-CHI) model systems is possible. The experiments were performed for particular (succinonitrile) systems. Several solutions are possible in Microgravity Sciences and Applications (MSA) experiments on future Shuttle missions. The theory of the T-CHI concept is evaluated. Although particular cases are used for explanations, the concepts developed will be universal. A breadboard system design is also presented for ultimate fabrication and testing of theoretical findings. New developments in holography involving optical fibers and diode lasers are also incorporated

Armed Intervention and Civilian Victimization in Intrastate Conflicts

Abstract Research has begun to examine the relationship between changes in the conflict environment and levels of civilian victimization. We extend this work by examining the effect of external armed intervention on the decisions of governments and insurgent organizations to victimize civilians during civil wars. We theorize that changes in the balance of power in an intrastate conflict influence combatant strategies of violence. As a conflict actor weakens relative to its adversary, it employs increasingly violent tactics toward the civilian population as a means of reshaping the strategic landscape to its benefit. The reason for this is twofold. First, declining capabilities increase resource needs at the moment that extractive capacity is in decline. Second, declining capabilities inhibit control and policing, making less violent means of defection deterrence more difficult. As both resource extraction difficulties and internal threats increase, actors' incentives for violence against the population increase. To the extent that biased military interventions shift the balance of power between conflict actors, we argue that they alter actor incentives to victimize civilians. Specifically, intervention should reduce the level of violence employed by the supported faction and increase the level employed by the opposed faction. We test these arguments using data on civilian casualties and armed intervention in intrastate conflicts from 1989 to 2004. Our results support our expectations, suggesting that interventions shift the power balance and affect the levels of violence employed by combatants

A phase I trial of ispinesib, a kinesin spindle protein inhibitor, with docetaxel in patients with advanced solid tumours

The aim of this study is to define the maximum tolerated dose (MTD), safety, pharmacokinetics (PKs) and efficacy of ispinesib (SB-715992) in combination with docetaxel. Patients with advanced solid tumours were treated with ispinesib (6–12 mg m−2) and docetaxel (50–75 mg m−2). Docetaxel was administered over 1 h followed by a 1-h infusion of ispinesib on day 1 of a 21-day schedule. At least three patients were treated at each dose level. Blood samples were collected during cycle 1 for PK analysis. Clinical response assessments were performed every two cycles using RECIST guidelines. Twenty-four patients were treated at four dose levels. Prolonged neutropaenia and febrile neutropaenia were dose limiting in six and two patients, respectively. The MTD was ispinesib 10 mg m−2 with docetaxel 60 mg m−2. Pharmacokinetic assessment demonstrated concentrations of ispinesib and docetaxel, consistent with published data from single agent studies of the drugs. Seven patients (six hormone refractory prostate cancer (HRPC), one renal cancer) had a best response of stable disease (⩾18 weeks). One patient with HRPC had a confirmed >50% prostatic-specific antigen decrease. The MTD for ispinesib and docetaxel was defined and the combination demonstrated an acceptable toxicity profile. Preliminary PK data suggest no interaction between ispinesib and docetaxel

Trade Potential and UN Peacekeeping Participation

The determinants of a country's UN peacekeeping troop contribution have been persistently studied. Trade, as a crucial self-interest motivation, is one of the important explanatory variables in the extant literature. However, the existing literature presents mixed results on the influence of trade on peacekeeping troop contributions. To capture the effect of trade on contributions precisely, we need to model expectations about future trade volume in a better way. Countries are pressured by the economic and political risks caused by the trade disruption and lobby groups to send peacekeeping troops to enable future trade or secure future investments. Therefore, trade potential, rather than realized trade, drives peacekeeping troop contributions. A gravity model is used to measure the trade potential between the UN peacekeeping mission countries and contributors, and test its relationship with the UN peacekeeping participation. Based on this measurement and a dyadic troop contribution dataset covering the period from 1990 to 2012, this article demonstrates that the counter-factual predictive trade volume is a relevant predictor of UN peacekeeping troop contributions

Small molecule binding sites on the Ras:SOS complex can be exploited for inhibition of Ras activation.

Constitutively active mutant KRas displays a reduced rate of GTP hydrolysis via both intrinsic and GTPase-activating protein-catalyzed mechanisms, resulting in the perpetual activation of Ras pathways. We describe a fragment screening campaign using X-ray crystallography that led to the discovery of three fragment binding sites on the Ras:SOS complex. The identification of tool compounds binding at each of these sites allowed exploration of two new approaches to Ras pathway inhibition by stabilizing or covalently modifying the Ras:SOS complex to prevent the reloading of Ras with GTP. Initially, we identified ligands that bound reversibly to the Ras:SOS complex in two distinct sites, but these compounds were not sufficiently potent inhibitors to validate our stabilization hypothesis. We conclude by demonstrating that covalent modification of Cys118 on Ras leads to a novel mechanism of inhibition of the SOS-mediated interaction between Ras and Raf and is effective at inhibiting the exchange of labeled GDP in both mutant (G12C and G12V) and wild type Ras