Sustainable Development in the Sahel Region

Scientists from various fields have long examined the factors contributing to sustainable development in Africa. The paper investigates the topic of sustainable development focusing on a very special part of Africa, the Sahel region, which is an ecoclimatic and biogeographic region of Africa facing many challenges. Consequently, the secondary research to be presented in this paper aims to review some projects and actions taken by various organizations, like the United Nations and the African Union, that stimulate sustainable development in the Sahel region. Accordingly, it focuses on a few of those projects and actions, which, on the one hand, enable sustainable agriculture, the reduction of malnutrition and food insecurity, and water usage combined with latrine construction, and which, on the other hand, enhance natural resource management and increasing resilience to climate change. The paper concludes with some remarks regarding the efficacy of these projects and actions from the viewpoint of sustainability, and finds that even though these projects and actions are of significance, there is still a long road ahead to reach sustainable development in the Sahel region

Mechanism of formation of the honeycomb-like structures by the regime of the reversing current (RC) in the second range

Electrodeposition of copper in the hydrogen co-deposition range by the regime of reversing current (RC) in the second range has been investigated by determination of the average current efficiency for hydrogen evolution reaction and by scanning electron (SEM) and optical (OM) microscopic analysis of the obtained deposits. Keeping the cathodic current density, the cathodic and the anodic pulses constant in all experiments, the anodic current density (ja) values were varied: 40, 80, 160, 240 and 320 mA cm−2. The Cu deposits produced by the RC regimes with different anodic current density values were compared with that obtained in a constant galvanostatic regime (DC) at the current density equal to the cathodic current density in the RC regimes. The honeycomb-like structures were formed in the DC regime and by the RC regimes with ja of 40 and 80 mA cm−2. The hole size in them was in the 60–70 μm range. Due to the decrease of quantity of evolved hydrogen with increasing anodic current density, the larger dish-like holes with dendrites at their bottom and shoulder were formed with ja values of 160, 240 and 320 mA cm−2. The maximum number of holes, and hence, the largest specific surface area of the honeycomb-like electrodes was obtained with ja = 80 mA cm−2, that can be ascribed to a suppression of coalescence of neighboring hydrogen bubbles. Application of the RC regime also led to the increase of uniformity of structures, what is concluded by cross section analysis of the formed honeycomb-like electrodes. For the first time, mechanism of Cu electrodeposition in the hydrogen co-deposition range by the RC regime in the second range was proposed and discussed.This is peer-reviewed version of the article: Journal of Electroanalytical Chemistry, 2019, 833, 401-410, [https://doi.org/10.1016/j.jelechem.2018.12.021][http://cer.ihtm.bg.ac.rs/handle/123456789/2986

Challenging Misinformation: Exploring Limits and Approaches

The manipulation of information and the dissemination of “fake news” are practices that trace back to the early records of human history. Significant changes in the technological environment enabling ubiquity, immediacy and considerable anonymity, have facilitated the spreading of misinformation in unforeseen ways, raising concerns around people’s (mis)perception of social issues worldwide. As a wicked problem, limiting the harm caused by misinformation goes beyond technical solutions, requiring also regulatory and behavioural changes. This workshop proposes to unpack the challenge at hand by bringing together diverse perspectives to the problem. Based on participatory design principles, it will challenge participants to critically reflect the limits of existing socio-technical approaches and co-create scenarios in which digital platforms support misinformation resilience

A novel TPR-BEN domain interaction mediates PICH-BEND3 association

PICH is a DNA translocase required for the maintenance of chromosome stability in human cells. Recent data indicate that PICH co-operates with topoisomerase IIα to suppress pathological chromosome missegregation through promoting the resolution of ultra-fine anaphase bridges (UFBs). Here, we identify the BEN domain-containing protein 3 (BEND3) as an interaction partner of PICH in human cells in mitosis. We have purified full length PICH and BEND3 and shown that they exhibit a functional biochemical interaction in vitro. We demonstrate that the PICH-BEND3 interaction occurs via a novel interface between a TPR domain in PICH and a BEN domain in BEND3, and have determined the crystal structure of this TPR-BEN complex at 2.2 Å resolution. Based on the structure, we identified amino acids important for the TPR-BEN domain interaction, and for the functional interaction of the full-length proteins. Our data reveal a proposed new function for BEND3 in association with PICH, and the first example of a specific protein-protein interaction mediated by a BEN domain

Duplex DNA and BLM regulate gate opening by the human TopoIIIα-RMI1-RMI2 complex

Topoisomerase IIIα is a type 1A topoisomerase that forms a complex with RMI1 and RMI2 called TRR in human cells. TRR plays an essential role in resolving DNA replication and recombination intermediates, often alongside the helicase BLM. While the TRR catalytic cycle is known to involve a protein-mediated single-stranded (ss)DNA gate, the detailed mechanism is not fully understood. Here, we probe the catalytic steps of TRR using optical tweezers and fluorescence microscopy. We demonstrate that TRR forms an open gate in ssDNA of 8.5 ± 3.8 nm, and directly visualize binding of a second ssDNA or double-stranded (ds)DNA molecule to the open TRR-ssDNA gate, followed by catenation in each case. Strikingly, dsDNA binding increases the gate size (by ~16%), while BLM alters the mechanical flexibility of the gate. These findings reveal an unexpected plasticity of the TRR-ssDNA gate size and suggest that TRR-mediated transfer of dsDNA may be more relevant in vivo than previously believed

Integrating Comprehensive Geriatric Assessment for people with COPD and frailty starting pulmonary rehabilitation: the Breathe Plus feasibility trial protocol.

One in five people with COPD also lives with frailty. People living with both COPD and frailty are at increased risk of poorer health and outcomes, and face challenges to completing pulmonary rehabilitation. Integrated approaches that are adapted to the additional context of frailty are required. The aim of the present study is to determine the feasibility of conducting a randomised controlled trial of an integrated Comprehensive Geriatric Assessment for people with COPD and frailty starting pulmonary rehabilitation. This is a multicentre, mixed-methods, assessor-blinded, randomised, parallel group, controlled feasibility trial ("Breathe Plus"; ISRCTN13051922). We aim to recruit 60 people aged ≥50 with both COPD and frailty referred for pulmonary rehabilitation. Participants will be randomised 1:1 to receive usual pulmonary rehabilitation, or pulmonary rehabilitation with an additional Comprehensive Geriatric Assessment. Outcomes (physical, psycho-social and service use) will be measured at baseline, 90 days and 180 days. We will also collect service and trial process data, and conduct qualitative interviews with a sub-group of participants and staff. We will undertake descriptive analysis of quantitative feasibility outcomes (recruitment, retention, missing data, blinding, contamination, fidelity), and framework analysis of qualitative feasibility outcomes (intervention acceptability and theory, outcome acceptability). Recommendations on progression to a full trial will comprise integration of quantitative and qualitative data, with input from relevant stakeholders. This study has been approved by a UK Research Ethics Committee (ref.: 19/LO/1402). This protocol describes the first study testing the feasibility of integrating a Comprehensive Geriatric Assessment alongside pulmonary rehabilitation, and testing this intervention within a mixed-methods randomised controlled trial

Computational fact checking from knowledge networks

Traditional fact checking by expert journalists cannot keep up with the enormous volume of information that is now generated online. Computational fact checking may significantly enhance our ability to evaluate the veracity of dubious information. Here we show that the complexities of human fact checking can be approximated quite well by finding the shortest path between concept nodes under properly defined semantic proximity metrics on knowledge graphs. Framed as a network problem this approach is feasible with efficient computational techniques. We evaluate this approach by examining tens of thousands of claims related to history, entertainment, geography, and biographical information using a public knowledge graph extracted from Wikipedia. Statements independently known to be true consistently receive higher support via our method than do false ones. These findings represent a significant step toward scalable computational fact-checking methods that may one day mitigate the spread of harmful misinformation

Nominal anchoring: Specificity, definiteness and article systems across languages

The papers in this volume address to different degrees issues on the relationship of articles systems and the pragmatic notions of definiteness and specificity in typologically diverse languages: Vietnamese, Siwi (Berber), Russian, Mopan (Mayan), Persian, Danish and Swedish. The main questions that motivate this volume are: How do languages with and without an article system go about helping the hearer to recognize whether a given noun phrase should be interpreted as definite, specific or non-specific? Is there clear-cut semantic definiteness without articles or do we find systematic ambiguity regarding the interpretation of bare noun phrases? If there is ambiguity, can we still posit one reading as the default? What exactly do articles in languages encode that are not analyzed as straightforwardly coding (in)definiteness? Do we find linguistic tools in these languages that are similar to those found in languages without articles? Most contributions report on research on different corpora and elicited data or present the outcome of various experimental studies. One paper presents a diachronic study of the emergence of article systems. On the issue of how languages with and without articles guide the hearer to the conclusion that a given noun phrase should be interpreted as definite, specific or non-specific, the studies in this paper argue for similar strategies. The languages investigated in this volume use constructions and linguistic tools that receive a final interpretation based on discourse prominence considerations and various aspects of the syntax-semantics interface. In case of ambiguity between these readings, the default interpretation is given by factors (e. g., familiarity, uniqueness) that are known to contribute to the salience of phrases, but may be overridden by discourse prominence. Articles that do not straightforwardly mark (in)definiteness encode different kinds of specificity. In the languages studied in this volume, whether they have articles or do not have an article system, we find similar factors and linguistic tools in the calculation process of interpretations. The volume contains revised selected papers from the workshop entitled Specificity, definiteness and article systems across languages held at the 40th Annual Conference of the German Linguistic Society (DGfS), 7-9 March, 2018 at the University of Stuttgart

Nominal anchoring: Specificity, definiteness and article systems across languages

The papers in this volume address to different degrees issues on the relationship of articles systems and the pragmatic notions of definiteness and specificity in typologically diverse languages: Vietnamese, Siwi (Berber), Russian, Mopan (Mayan), Persian, Danish and Swedish. The main questions that motivate this volume are: How do languages with and without an article system go about helping the hearer to recognize whether a given noun phrase should be interpreted as definite, specific or non-specific? Is there clear-cut semantic definiteness without articles or do we find systematic ambiguity regarding the interpretation of bare noun phrases? If there is ambiguity, can we still posit one reading as the default? What exactly do articles in languages encode that are not analyzed as straightforwardly coding (in)definiteness? Do we find linguistic tools in these languages that are similar to those found in languages without articles? Most contributions report on research on different corpora and elicited data or present the outcome of various experimental studies. One paper presents a diachronic study of the emergence of article systems. On the issue of how languages with and without articles guide the hearer to the conclusion that a given noun phrase should be interpreted as definite, specific or non-specific, the studies in this paper argue for similar strategies. The languages investigated in this volume use constructions and linguistic tools that receive a final interpretation based on discourse prominence considerations and various aspects of the syntax-semantics interface. In case of ambiguity between these readings, the default interpretation is given by factors (e. g., familiarity, uniqueness) that are known to contribute to the salience of phrases, but may be overridden by discourse prominence. Articles that do not straightforwardly mark (in)definiteness encode different kinds of specificity. In the languages studied in this volume, whether they have articles or do not have an article system, we find similar factors and linguistic tools in the calculation process of interpretations. The volume contains revised selected papers from the workshop entitled Specificity, definiteness and article systems across languages held at the 40th Annual Conference of the German Linguistic Society (DGfS), 7-9 March, 2018 at the University of Stuttgart