Towards Efficient Full Pose Omnidirectionality with Overactuated MAVs

Omnidirectional MAVs are a growing field, with demonstrated advantages for aerial interaction and uninhibited observation. While systems with complete pose omnidirectionality and high hover efficiency have been developed independently, a robust system that combines the two has not been demonstrated to date. This paper presents VoliroX: a novel omnidirectional vehicle that can exert a wrench in any orientation while maintaining efficient flight configurations. The system design is presented, and a 6 DOF geometric control that is robust to singularities. Flight experiments further demonstrate and verify its capabilities.Comment: 10 pages, 6 figures, ISER 2018 conference submissio

Open challenges in the management of autoimmune hepatitis

Autoimmune Hepatitis (AIH) is a rare autoimmune disease of the liver with many open questions as regards its aetiopathogenesis, natural history and clinical management. The classical picture of AIH is chronic hepatitis with fluctuating elevation of serum transaminases and Immunoglobulin G levels, the presence of circulating autoantibodies and typical histological features. However, atypical presentations do occur and are not well captured by current diagnostic scores, with important consequences in terms of missed diagnoses and delayed treatments. AIH is treated with corticosteroids and immunosuppressive drugs but up to 40% of patients do not achieve full biochemical response and are at risk of progressing to cirrhosis and liver failure. Moreover, standard therapies are associated by significant side-effects which may impair the quality of life of patients living with AIH. However, advances in the understanding of the underlying immunology of AIH is raising the prospect of novel therapies and optimisation of existing therapeutic approaches to reduce side-effect burdens and potentially restore immunological tolerance. In this review we outline the clinical characteristics, aetiopathogenesis and management of AIH and current challenges in the diagnosis and management of AIH and provide evidence underlying the evolution of diagnostic and clinical management protocols

Comparison between Fractal and Statistical Approaches to Model Size Effects in VHCF

Size effects concern the anomalous scaling of relevant mechanical properties of materials and structures over a sufficiently wide dimensional range. In the last few years, thanks to technological advances, such effects have been experimentally detected also in the very high cycle fatigue (VHCF) tests. Research groups at Politecnico di Torino are very active in this field, observing size effects on fatigue strength, fatigue life and fatigue limit up to the VHCF regime for different metal alloys. In addition, different theoretical models have been put forward to explain these effects. In the present paper, two of them are introduced, respectively based on fractal geometry and statistical concepts. Furthermore, a comparison between the models and experimental results is provided. Both models are able to predict the decrement in the fatigue life and in the conventional fatigue limit

Circuit training during physical education classes to prepare cadets for military academies tests: Analysis of an educational project

Background: The aim of this study was to test the efficacy of an eight-week physical education program based on circuit training to better improve the overall physical and military-specific performance compared to a conventional physical education program in military high school students. Methods: Sixty-four students were enrolled in this study and randomly assigned to an experimental (EG, circuit training) or a control group (CG, traditional physical education program). Immediately before and after the eight-week training period, participants were tested on strength and endurance performance, circuit training tests, and military tests. Moreover, the acquisition of the educational objectives and the pleasantness of the experimental intervention were tested using a qualitative approach. Results: Despite the higher workload in EG than CG during the training period, the effect of the experimental intervention compared to the control was only possibly to likely positive for a few strength and endurance performances and circuit training tests, respectively. A trivial effect was shown in the military tests. On the contrary, the high percentage of motivation (76%), understanding (78%) and collaboration (86%) showed by the students suggests the achievement of acquisition of the educational objectives and a fair pleasantness of the lessons. Conclusions: A lack of clear and marked effect of the experimental intervention could be ascribed to an insufficient exposure time to the training and a high subjective overall workload encountered in military high school students

Effects of Fat Supplementation in Dairy Goats on Lipid Metabolism and Health Status

Fat supplementation has long been used in dairy ruminant nutrition to increase the fat content of milk and supply energy during particularly challenging production phases. Throughout the years, advances have been made in the knowledge of metabolic pathways and technological treatments of dietary fatty acids (FAs), resulting in safer and more widely available lipid supplements. There is an awareness of the positive nutraceutical effects of the addition of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) to fat supplementation, which provides consumers with healthier animal products through manipulation of their characteristics. If it is true that benefits to human health can be derived from the consumption of animal products rich in bioactive fatty acids (FAs), then it is reasonable to think that the same effect can occur in the animals to which the supplements are administered. Therefore, recent advances in fat supplementation of dairy goats with reference to the effect on health status have been summarized. In vivo trials and in vitro analysis on cultured cells, as well as histological and transcriptomic analyses of hepatic and adipose tissue, have been reviewed in order to assess documented relationships between specific FAs, lipid metabolism, and immunity

Optimal detection of losses by thermal probes

We consider the discrimination of lossy bosonic channels and focus to the case when one of the values for the loss parameter is zero, i.e., we address the detection of a possible loss against the alternative hypothesis of an ideal lossless channel. This discrimination is performed by inputting one-mode or two-mode squeezed thermal states with fixed total energy. By optimizing over this class of states, we find that the optimal inputs are pure, thus corresponding to single- and two-mode squeezed vacuum states. In particular, we show that for any value of the damping rate smaller than a critical value there is a threshold on the energy that makes the two-mode squeezed vacuum state more convenient than the corresponding single-mode state, whereas for damping larger than this critical value two-mode squeezed vacua are always better. We then consider the discrimination in realistic conditions, where it is unlikely to have pure squeezing. Thus by fixing both input energy and squeezing, we show that two-mode squeezed thermal states are always better than their single- mode counterpart when all the thermal photons are directed into the dissipative channel. Besides, this result also holds approximately for unbalanced distribution of the thermal photons. Finally, we also investigate the role of correlations in the improvement of detection. For fixed input squeezing (single-mode or two-mode), we find that the reduction of the quantum Chernoff bound is a monotone function of the two-mode entanglement as well as the quantum mutual information and the quantum discord. We thus verify that employing squeezing in the form of correlations (quantum or classical) is always a resource for loss detection whenever squeezed thermal states are taken as input.Comment: 13 pages, 8 figures. Revised versio

Benign hereditary chorea and deletions outside NKX2-1 : what's the role of MBIP?

Heterozygous point mutations or deletions of the NKX2-1 gene cause benign hereditary chorea (BHC) or a various combinations of primary hypothyroidism, respiratory distress and neurological disorders. Deletions proximal to, but not encompassing, NKX2-1 have been described in few subjects with brain-lung-thyroid syndrome. We report on a three-generation Italian family, with 6 subjects presenting BHC and harboring a genomic deletion adjacent to NKX2-1 and including the gene MBIP, recently proposed to be relevant for the pathogenesis of brain-lung-thyroid syndrome. We observed a clear reduction of NKX2-1 transcript levels in fibroblasts from our patients compared to controls; this finding suggests that MBIP deletion affects NKX2-1 expression, mimicking haploinsufficiency caused by classical NKX2-1 related mutations