Architettura stratigrafica ed evoluzione del Golfo di Pozzuoli negli ultimi 15 ka:una nuova prospettiva sulla caldera del Tufo Giallo Napoletano,Campi Flegrei, margine tirrenico orientale.

I Campi Flegrei rappresentano un distretto vulcanico attivo che si sviluppa al confine tra il settore emerso e sommerso del margine continentale campano. Il distretto vulcanico occupa una superficie di circa 200 km2, è strutturalmente dominato da una caldera di collasso del diametro di circa 8 km formatasi in seguito all’eruzione del Tufo Giallo Napoletano (TGN), un deposito ignimbritico del volume di 30-50 km3 Dense Rock Equivalent, datato a 15 ka B.P. circa, ed è attivo da almeno 78 ka B.P circa. L’obiettivo di questo lavoro è di ricostruire l’architettura stratigrafica e l’evoluzione vulcanotettonica tardo-Quaternaria del sistema caldera di collasso - faglia anulare - risorgenza intra-calderica del settore sommerso della caldera del TGN. A tal fine è stata analizzata una fitta maglia di profili sismici a riflessione monocanale di alta (Sparker) ed altissima (Subbottom Chirp) risoluzione. I dati sismici sono stati successivamente integrati sia con quelli ottenuti dall’analisi di carotaggi a gravità e batimetrici multibeam che con quelli disponibili in letteratura e, nell’insieme, analizzati in ambiente GIS. I nuovi dati indicano che il settore interno dell’area collassata a seguito dell’eruzione del TGN evolve inizialmente in condizioni di mare basso. L’area intra-calderica viene successivamente interessata dalla formazione di una struttura antiforme (risorgenza intra-calderica) il cui tasso di sollevamento è stato comparabile con l’innalzamento eustatico nell’intervallo Pleistocene superiore – Olocene [Lambeck et al., 2011]. A circa 10 ka B.P. il settore centrale della struttura risorgente raggiunge l’esposizione subaerea (terrazzo morfologico de “La Starza”). La calibrazione dei profili sismici Chirp con markers tefro-stratigrafici riconosciuti in un carotaggio e datati al 1538 A.D., 79 A.D. indica l’instaurarsi di un periodo di subsidenza in epoca post-Romana, registrato dall’annegamento di 10-25 m del cuneo di progradazione infralittorale rispetto alle profondità di equilibrio funzionale attualmente segnalate in area Mediterranea. L’interpretazione sismostratigrafica rivela, inoltre, la presenza di fluidi che risalgono attraverso la zona di faglia anulare che delimita la caldera del TGN. Bibliografia Lambeck, K., Antonioli, F., Anzidei, M., Ferranti, L., Leoni, G., Scicchitano, G., Silenzi, S., (2011). Sea level change along the Italian coast during the holocene and projections for the future. Quaternary International, 232, 250-257

Seismic expression of the shallow structure of The Neapolitan Yellow Tuff (NYT) caldera offshore the Campi Flegrei

In this study we integrate high-resolution swath bathymetry, single-channel reflection seismic data and gravity core data, to provide new insights into the shallow structure and latest Quaternary to Holocene evolution of the submerged sector of the Neapolitan Yellow Tuff (NYT) caldera (Campi Flegrei) in the Pozzuoli Bay. The new data allow for a reconstruction of the offshore geometry of the NYT caldera collapse \u2013 ring fault system, along with the style and timing of deformation of the inner caldera resurgence. Our interpretation shows that the NYT eruption (~15 ka BP) was associated with a caldera collapse bounded by an inward-dipping ring fault system. The ring fault system consists in a 1-2 km wide fault zone that encircles an inner caldera region ~ 5 km in diameter and is often marked by the occurrence of pore fluids ascending through the fault zone, up to the seafloor, particularly in the western sector of the bay. A shallow magmatic intrusion along the ring fault zone was also detected offshore Bagnoli in the eastern part of the Pozzuoli Bay (Sacchi et al., 2014). Following the NYT eruption, the inner caldera region underwent significant deformation and resurgence with a maximum cumulative uplift of the offshore structure in the order of 180 m. The net uplift rate of the caldera resurgent dome was ~ 9 - 12 mm/year during the period 15.0 \u2013 6.6 ka BP. The style of deformation of the resurgent structure can be described in terms of a broad doming, accompanied by subordinate brittle deformation, mostly concentrated in a small apical graben at the summit of the resurgent dome (Cole et al., 2005). Chronostratigraphic calibration of seismic profiles obtained by three tephra layers cored in the Pozzuoli Bay indicates 5 to 25 m of post-Roman differential subsidence and tilting towards ESE of the inner caldera resurgence, as recorded by the drowning of the infralittoral prograding wedge below the present-day storm wave base

The Neapolitan Yellow Tuff caldera offshore the Campi Flegrei: Stratal architecture and kinematic reconstruction during the last 15 ky

In this study we integrate high-resolution swath bathymetry, single channel reflection seismic data and gravity core data, to provide new insights into the shallow structure and latest Quaternary to Holocene evolution of the submerged sector of the Neapolitan Yellow Tuff (NYT) caldera (Campi Flegrei) in the Pozzuoli Bay. The new data allow for a reconstruction of the offshore geometry of the NYT caldera collapse\u2013ring fault system, along with the style and timing of deformation of the inner caldera resurgence. Our interpretation shows that the NYT eruption (~15 ka BP) was associated with a caldera collapse bounded by an inward-dipping ring fault system. The ring fault system consists in a 1\u20132 km wide fault zone that encircles an inner caldera region ~5 km in diameter and is often marked by the occurrence of pore fluids ascending through the fault zone, up to the seafloor, particularly in the western sector of the bay. A shallow magmatic intrusion along the ring fault zone was also detected offshore Bagnoli in the eastern part of the Pozzuoli Bay. Following the NYT eruption, the inner caldera region underwent significant deformation and resurgence with a maximum cumulative uplift of the offshore structure in the order of 180 m. The net uplift rate of the caldera resurgent dome was ~9\u201312 mm/year during the period 15.0\u20136.6 ka BP. The style of deformation of the resurgent structure can be described in terms of a broad doming, accompanied by subordinate brittle deformation, mostly concentrated in a small apical graben at the summit of the resurgent dome. Chronostratigraphic calibration of seismic profiles obtained by three tephra layers cored in the Pozzuoli Bay indicates 5 to 25 m of post-Roman differential subsidence and tilting towards ESE of the inner caldera resurgence, as recorded by the drowning of the infralittoral prograding wedge below the present-day storm wave base

Impact of Candida species colonization and azoles resistance in a neonatal intensive care unit

Background: Candida species are among the top 10 most frequently isolated nosocomial bloodstream pathogens in Europe. In particular, in neonatal intensive care units (NICUs) Candida infections are an emerging concern because of the increasing incidence, the related high morbidity and mortality rates reported. Moreover, the epidemiology of Candida infection rapidly changed in these years leading to the selection of less sensitive strains and species. Surveillance studies are mandatory to identify the local distribution of species, their antifungal susceptibility profiles and the emergence of resistance strains. Material/methods: From December 2012 we performed a cohort prospective surveillance study in our NICU, collecting weekly nasal and rectal swabs. Swabs were placed on Sabouraud agar. Candida growth on agar plates was confirmed by microscopic observation. Furthermore, Candida spp. was identified through Candida chromogenic agar (Candida chromogenic agar, Laboratorios Conda) and API\uae 20C AUX (Biom\ue9rieux). The first isolated non-C.albicans Candida (NCAC) species from colonized patients were tested with the main antifungal agents (YeastOne\uae Y010 Thermo Fisher Scientific) and the obtained MIC values were read according to CLSI. Results: From December 2012 to June 2016 we enrolled 874 neonates and analyzed respectively 2014 nasal and rectal swabs. 20/2014 (0,99%) of nasal swabs and 128/2014 (6,35%) of rectal swabs tested positive for Candida spp. The species distribution is showed in the Graph 1. 89/874 (10,18%) neonates tested positive at least in one swab. 59 isolates of NCAC species were tested with the main antifungal agents. All the tested strains were susceptible to echinocandins and amphotericin B. The susceptibility patterns for azoles are shown in the Table 1. Conclusions: Our study confirm the rule of surveillance in the prevention and control of Candida spp. healthcare related infections especially in an high risk ward such as NICU. In particular, in our NICU fluconazole prophylaxis is administered according to standard protocols from 2009.Antifungal susceptibility testes allowed to identify resistant and mutant strains whom acquired resistance so to obtain both clinical and epidemiological data promptly

The submerged structure and stratal architecture of the Neapolitan Yellow Tuff (NYT) caldera, offshore the Campi Flegrei, (Eastern Tyrrhenian Margin): new insights from high resolution seismics and gravity core data

The Campi Flegrei is an active volcanic area defined by a quasi-circular depression that covers some 200 km2 of the coastal zone of SW Italy, a large part of which develops off the Naples (Pozzuoli) Bay (Fig. 1). The area has been active at least since 60 ka BP ( Pappalardo et al., 1999), and is structurally dominated by a caldera, 6 km in diameter, associated with the eruption of the Neapolitan Yellow Tuff (NYT), a 40 km3 Dense Rock Equivalent (DRE) ignimbrite (Scarpati et al., 1993) dated at ca 15 ka BP (Deino et al., 2004), that covered the district now occupied by the city of Naples, the Campi Flegrei and a large area of the continental shelf off the Pozzuoli Bay. The volcanological evolution of the NYT caldera as been long described on the basis of outcrop and subsurface studies onland (Rosi & Sbrana, 1987; Orsi et al., 1996, 2004 and references therein; Di Vito et al., 1999; Perrotta et al., 2006; Fedele et al., 2011), but its offshore morphology, detailed structure and recent stratigraphic setting are still poorly understood. In this study we integrate geological and geophysical data of different resolution/penetration obtained from high-resolution reflection seismic profiles (Sparker and Chirp source) with gravity core and swath bathymetry to better constrain the shallow structure, stratigraphic architecture and latest Quaternary to Holocene evolution of the submerged sector of the NYT caldera off the Pozzuoli Bay. Our data clearly image, for the first time, the offshore geometry of the NYT caldera ring-fault zone, as well as the style and timing of volcano-tectonic deformation associated with the late stage evolution of the NYT inner caldera resurgence. Our interpretation suggests that since 15 ka the offshore sector of NYT inner caldera underwent significant deformation and uplift (with minor subsidence episodes) that occurred at almost the same rate as the post-glacial sea-level rise. Particularly, the inner Pozzuoli Bay started to deform soon after 15 ka BP, when sea-level rise was initially faster than uplift. This caused a general increase of the accommodation space that was progressively filled up by volcaniclastic sediments. Since ca. 8 ka BP, along with the mid Holocene decrease in the rate of the sea-level rise, the early NYT resurgent structure was then uplifted up to the sea-level or even to partial subaerial exposure. From ca. 8 to 5 ka BP two distinct layers of volcaniclastic resediments, mostly represented by gravity flow deposits, formed throughout the Bay. A significant post- Roman (post 2 ka BP) subsidence phase of ca 10 m is then recorded offshore Pozzuoli by the drowning of the infralittoral prograding wedge below the present-day fair-weather wave base. REFERENCES Deino AL, Orsi G, de Vita S, Piochi M (2004) The age of the Neapolitan Yellow Tuff caldera-forming eruption (Campi Flegrei caldera—Italy) assessed by 40Ar/39Ar dating method. J. Volcanol. Geotherm. Res. 133, 157–170. Di Vito M., Isaia R., Orsi G., Southon J., de Vita S., D’Antonio M., Pappalardo L., Piochi M., 1999. Volcanism and deformation since 12,000 years at the Campi Flegrei caldera (Italy), J. Volcanol. Geotherm. Res. 91 (2-4), 221-246. Fedele L., Insinga D.D., Calvert A.T., Morra V., Perrotta A., Scarpati C., 2011. 40Ar/39Ar dating of tuff vents in the Campi Flegrei caldera (southern Italy): toward a new chronostratigraphic reconstruction of the Holocene volcanic activity. Bull. Volcanol. 73, 1323-1336. Orsi G, de Vita S, Di Vito M, 1996. The restless, resurgent Campi Flegrei nested caldera (Italy): constraints on its evolution and configuration. J. Volcanol. Geotherm. Res. 74, 179–214. Orsi G., Di Vito M.A. Isaia R., 2004. Volcanic hazard assessment at the restless Campi Flegrei caldera. Bull. Volcanol. 66, 514–530. Pappalardo L., Civetta L., D’Antonio M., Deino A., Di Vito M., Orsi G., Carandente A., de Vita S., Isaia R. & Piochi M., 1999. Chemical and Srisotopical evolution of the Phlegrean magmatic system before the Campanian Ignimbrite and the Neapolitan Yellow Tuff eruptions J. Volcanol. Geotherm. Res. 91, 141-166. Perrotta A., Scarpati C., Luongo G., Morra V., 2006. The Campi Flegrei caldera boundary in the city of Naples. In: De Vivo B (ed) Volcanism in the Campania Plain: Vesuvius, Campi Flegrei and Ignimbrites. Elsevier, Amsterdam, pp 85–96 (in the series Developments in Volcanology, 9) Scarpati C., Cole P., & Perrotta A., 1993. The Neapolitan Yellow Tuff- A large volume multiphase eruption from Campi Flegrei, Southern Italy. Bull. Volcan. 55, 343-35

A coordinated DNA damage response promotes adult quiescent neural stem cell activation

Stem and differentiated cells frequently differ in their response to DNA damage, which can determine tissue sensitivity. By exploiting insight into the spatial arrangement of subdomains within the adult neural subventricular zone (SVZ) in vivo, we show distinct responses to ionising radiation (IR) between neural stem and progenitor cells. Further, we reveal different DNA damage responses between neonatal and adult neural stem cells (NSCs). Neural progenitors (transit amplifying cells and neuroblasts) but not NSCs (quiescent and activated) undergo apoptosis after 2 Gy IR. This response is cell type- rather than proliferationdependent and does not appear to be driven by distinctions in DNA damage induction or repair capacity. Moreover, exposure to 2 Gy IR promotes proliferation arrest and differentiation in the adult SVZ. These 3 responses are ataxia telangiectasia mutated (ATM)- dependent and promote quiescent NSC (qNSC) activation, which does not occur in the subdomains that lack progenitors. Neuroblasts arising post-IR derive from activated qNSCs rather than irradiated progenitors, minimising damage compounded by replication or mitosis. We propose that rather than conferring sensitive cell death, apoptosis is a form of rapid cell death that serves to remove damaged progenitors and promote qNSC activation. Significantly, analysis of the neonatal (P5) SVZ reveals that although progenitors remain sensitive to apoptosis, they fail to efficiently arrest proliferation. Consequently, their repopulation occurs rapidly from irradiated progenitors rather than via qNSC activation

DISFUNZIONE MULTIORGANO (MOF) IN CORSO DI ENCEFALOPATIA NEONATALE. INDAGINE EPIDEMIOLOGICA SU UN CAMPIONE DI NEONATI OSSERVATI NEL PERIODO GENNAIO 2009 - MAGGIO 2016

encefalopatia, disfunzione multirogan

Economic burden of vulvar and vaginal intraepithelial neoplasia: retrospective cost study at a German dysplasia centre

<p>Abstract</p> <p>Background</p> <p>Human papillomavirus is responsible for a variety of diseases including grade 2 and 3 vulvar and vaginal intraepithelial neoplasia. The aim of this study was to assess parts of the burden of the last diseases including treatment costs. The direct medical resource use and cost of surgery associated with neoplasia and related diagnostic procedures (statutory health insurance perspective) were estimated, as were the indirect costs (productivity losses) associated with surgical treatment and related gynaecology visits for diagnostic purposes.</p> <p>Methods</p> <p>Data from 1991-2008 were retrospectively collected from patient records of the outpatient unit of the Gynaecological Dysplasia Clinic, Heinrich Heine University, Dusseldorf, Germany. Two subgroups of patients were analysed descriptively: women undergoing one surgical procedure related to a diagnosis of vulvar and/or vaginal intraepithelial neoplasia, and women undergoing two or more surgical procedures. Target measures were per-capita medical resource consumption, direct medical cost and indirect cost.</p> <p>Results</p> <p>Of the 94 women analysed, 52 underwent one surgical intervention and 42 two or more interventions (mean of 3.0 interventions during the total period of analysis). Patients undergoing one surgical intervention accrued €881 in direct costs and €682 in indirect costs; patients undergoing more than one intervention accrued €2,605 in direct costs and €2,432 in indirect costs.</p> <p>Conclusions</p> <p>The economic burden on German statutory health insurance funds and society induced by surgical interventions and related diagnostic procedures for grade 2/3 vulvar and vaginal neoplasia should not be underrated. The cost burden is one part of the overall burden attributable to human papillomavirus infections.</p

Integrated stratigraphy for the Late Quaternary in the eastern Tyrrhenian Sea

A high-resolution integrated stratigraphy is presented for the Late Quaternary in the southern-eastern Tyrrhenian Sea. It is based on calcareous plankton taxa (planktonic foraminifera and nannoplankton) distribution, d18OGlobigerinoides ruber record, tephrostratigraphy and radiometric dating methods (210Pb and 137Cs, AMS 14C) for a composite sediment core (from the top to the bottom, C90-1m, C90 and C836) from the continental shelf of the Salerno Gulf. High sedimentation rates from ca 1 cm/100 y for the early Holocene, to 3.45 cm/100 y for the middle Holocene to 8.78 cm/100 y from late Holocene and to 20 cm/100 y for the last 600 AD, make this area an ideal marine archive of secular paleoclimate changes. Quantitative distributional trend in planktonic foraminifera identify seven known (1Fe7F) eco-biozones, and several auxiliary bioevents of high potential for Mediterranean biostratigraphic correlation. Recognised were: the acme distribution of Neogloboquadrina pachyderma r.c. between 10.800 0.400 ka BP and 5.500 0.347 ka BP, a strong increase in abundance of Globorotalia truncatulinoides r.c. and l.c. at 5.500 0.347 ka BP and at 4.571 0.96 ka BP, respectively, an acme interval of Globigerinoides quadrilobatus (between 3.702 0.048 ka BP and 2.70 0.048 ka BP) and the acme/paracme intervals of T. quinqueloba (acme between 3.350 0.054 ka BP and 1.492 0.016 ka BP; paracme between 1.492 0.016 ka BP and 0.657 0.025 ka BP; acme beginning 0.657 0.025 ka BP). These results, integrated with trends of selected calcareous nannofossil species (Florisphaera profunda, Brarudosphaera bigelowii, Gephyrocapsa oceanica and Emiliania huxleyi) and d18OG. ruber signature, are consistent with the most important pre-Holocene and early Holocene paleoclimatic and paleoceanographic phases i.e., the BöllingeAllerod, the Younger Dryas and the time interval of Sapropel S1 deposition in the eastern Mediterranean Sea. These features revealed the high potential of this shallow water environment for high-resolution stratigraphy and correlation for the western Mediterranean. In addition, the chemical characterization of seven tephra layers supplied further data about the age and the dispersal area of some well-known Campi Flegrei explosive events, inferring the possible occurrence of explosive activity at Vesuvius around the middle of the 6th century, and contributing to refine the tephrostratigraphic framework for the last 15 ka in the south-eastern Tyrrhenian Sea.Published71-852.2. Laboratorio di paleomagnetismoJCR Journalrestricte