The Negativity Bias Predicts Response Rate To Behavioral Activation For Depression

Background and Objectives: This treatment study investigated the extent to which asymmetric dimensions of affective responding, specifically the positivity offset and the negativity bias, at pretreatment altered the rate of response to Behavioral Activation treatment for depression. Method: Forty-one depressed participants were enrolled into 16 weekly sessions of BA. An additional 36 lifetime healthy participants were evaluated prospectively for 16 weeks to compare affective responding between healthy and remitted patients at post-treatment. All participants were assessed at Weeks 0, 8 and 16 using repeated measures, involving a structured clinical interview for DSM-IV Axis I disorders, questionnaires, and a computerized task designed to measure affective responses to unpleasant, neutral, and pleasant images. Results: The negativity bias at pre-treatment predicted the rate of response to BA, while the positivity offset did not. Limitations: Only one treatment condition was used in this study and untreated depressed participants were not enrolled, limiting our ability to compare the effect of BA. Conclusions: Baseline negativity bias may serve as a signal for patients to engage in and benefit from the goal-directed BA strategies, thereby accelerating rate of response

Active Sampling-based Binary Verification of Dynamical Systems

Nonlinear, adaptive, or otherwise complex control techniques are increasingly relied upon to ensure the safety of systems operating in uncertain environments. However, the nonlinearity of the resulting closed-loop system complicates verification that the system does in fact satisfy those requirements at all possible operating conditions. While analytical proof-based techniques and finite abstractions can be used to provably verify the closed-loop system's response at different operating conditions, they often produce conservative approximations due to restrictive assumptions and are difficult to construct in many applications. In contrast, popular statistical verification techniques relax the restrictions and instead rely upon simulations to construct statistical or probabilistic guarantees. This work presents a data-driven statistical verification procedure that instead constructs statistical learning models from simulated training data to separate the set of possible perturbations into "safe" and "unsafe" subsets. Binary evaluations of closed-loop system requirement satisfaction at various realizations of the uncertainties are obtained through temporal logic robustness metrics, which are then used to construct predictive models of requirement satisfaction over the full set of possible uncertainties. As the accuracy of these predictive statistical models is inherently coupled to the quality of the training data, an active learning algorithm selects additional sample points in order to maximize the expected change in the data-driven model and thus, indirectly, minimize the prediction error. Various case studies demonstrate the closed-loop verification procedure and highlight improvements in prediction error over both existing analytical and statistical verification techniques.Comment: 23 page

Twice The Negativity Bias And Half The Positivity Offset: Evaluative Responses To Emotional Information In Depression

Background and objectives: Humans have the dual capacity to assign a slightly pleasant valence to neutral stimuli (the positivity offset) to encourage approach behaviors, as well as to assign a higher negative valence to unpleasant images relative to the positive valence to equally arousing and extreme pleasant images (the negativity bias) to facilitate defensive strategies. We conducted an experimental psychopathology study to examine the extent to which the negativity bias and the positivity offset differ in participants with and without major depression. Method: Forty-one depressed and thirty-six healthy participants were evaluated using a structured clinical interview for DSM-IV Axis I disorders, questionnaires, and a computerized task designed to measure implicit affective responses to unpleasant, neutral, and pleasant stimuli. Results: The negativity bias was significantly higher and the positivity offset was significantly lower in depressed relative to healthy participants. Limitations: Entry criteria enrolling medication-free participants with minimal DSM-IV comorbidity may limit generalizability of the findings. Conclusions: This study advances our understanding of the positive and negative valence systems in depression, highlighting the irregularities in the positive valence system

Properties of some conformal field theories with M-theory duals

By studying classes of supersymmetric solutions of D=11 supergravity with AdS_5 factors, we determine some properties of the dual four-dimensional N=1 superconformal field theories. For some explicit solutions we calculate the central charges and also the conformal dimensions of certain chiral primary operators arising from wrapped membranes. For the most general class of solutions we show that there is a consistent Kaluza-Klein truncation to minimal D=5 gauged supergravity. This latter result allows us to study some aspects of the dual strongly coupled thermal plasma with a non-zero R-charge chemical potential and, in particular, we show that the ratio of the shear viscosity to the entropy density has the universal value of 1/4 pi.Comment: Consistent truncation extended to include fermions. Reference added. 28 page

Consistent Group and Coset Reductions of the Bosonic String

Dimensional reductions of pure Einstein gravity on cosets other than tori are inconsistent. The inclusion of specific additional scalar and p-form matter can change the situation. For example, a D-dimensional Einstein-Maxwell-dilaton system, with a specific dilaton coupling, is known to admit a consistent reduction on S^2= SU(2)/U(1), of a sort first envisaged by Pauli. We provide a new understanding, by showing how an S^3=SU(2) group-manifold reduction of (D+1)-dimensional Einstein gravity, of a type first indicated by DeWitt, can be broken into in two steps; a Kaluza-type reduction on U(1) followed by a Pauli-type coset reduction on S^2. More generally, we show that any D-dimensional theory that itself arises as a Kaluza U(1) reduction from (D+1) dimensions admits a consistent Pauli reduction on any coset of the form G/U(1). Extensions to the case G/H are given. Pauli coset reductions of the bosonic string on G= (G\times G)/G are believed to be consistent, and a consistency proof exists for S^3=SO(4)/SO(3). We examine these reductions, and arguments for consistency, in detail. The structures of the theories obtained instead by DeWitt-type group-manifold reductions of the bosonic string are also studied, allowing us to make contact with previous such work in which only singlet scalars are retained. Consistent truncations with two singlet scalars are possible. Intriguingly, despite the fact that these are not supersymmetric models, if the group manifold has dimension 3 or 25 they admit a superpotential formulation, and hence first-order equations yielding domain-wall solutions.Comment: Latex, 5 figures, 45 pages, minor correction

Examining cognitive, motivational and environmental factors that relate to reading performance for children with English as a first or additional language

Mixed findings exist in the literature regarding the reading skills of children with English as an Additional Language (EAL). Moreover, little research has considered how related literacy skills, motivation, and environmental factors may differ between EAL children and English monolinguals, and how these factors may contribute to reading outcomes. The present study compared 36 children with EAL and 31 monolingual English children (mean age 9 years) on measures of reading, phonology, vocabulary, motivation and environmental factors. No group differences were found in word reading and reading fluency, phonological awareness, expressive vocabulary, reading motivation, time spent reading with a parent and independently, and parental attitudes to reading. However, maternal education was lower in the EAL group and these children had more children’s books at home than their monolingual peers. The findings confirm the importance of phonological awareness and expressive vocabulary for reading performance in both groups, as well as suggesting that maternal education may indirectly relate to EAL children’s reading abilities through maternal attitudes towards reading. In contrast, in the case of monolingual children, maternal education related to number of books in the home. Implications and suggestions for future research are discussed

Kaluza-Klein Consistency, Killing Vectors, and Kahler Spaces

We make a detailed investigation of all spaces Q_{n_1... n_N}^{q_1... q_N} of the form of U(1) bundles over arbitrary products \prod_i CP^{n_i} of complex projective spaces, with arbitrary winding numbers q_i over each factor in the base. Special cases, including Q_{11}^{11} (sometimes known as T^{11}), Q_{111}^{111} and Q_{21}^{32}, are relevant for compactifications of type IIB and D=11 supergravity. Remarkable ``conspiracies'' allow consistent Kaluza-Klein S^5, S^4 and S^7 sphere reductions of these theories that retain all the Yang-Mills fields of the isometry group in a massless truncation. We prove that such conspiracies do not occur for the reductions on the Q_{n_1... n_N}^{q_1... q_N} spaces, and that it is inconsistent to make a massless truncation in which the non-abelian SU(n_i+1) factors in their isometry groups are retained. In the course of proving this we derive many properties of the spaces Q_{n_1... n_N}^{q_1... q_N} of more general utility. In particular, we show that they always admit Einstein metrics, and that the spaces where q_i=(n_i+1)/\ell all admit two Killing spinors. We also obtain an iterative construction for real metrics on CP^n, and construct the Killing vectors on Q_{n_1... n_N}^{q_1... q_N} in terms of scalar eigenfunctions on CP^{n_i}. We derive bounds that allow us to prove that certain Killing-vector identities on spheres, necessary for consistent Kaluza-Klein reductions, are never satisfied on Q_{n_1... n_N}^{q_1... q_N}.Comment: Latex, 43 pages, references added and typos correcte

Splitting of Folded Strings in AdS_4*CP^3

We study classically splitting of two kinds of folded string solutions in AdS_4*CP^3. Conserved charges of the produced fragments are computed for each case. We find interesting patterns among these conserved charges.Comment: minor changes, 14 pages, no figure

More about Birkhoff's Invariant and Thorne's Hoop Conjecture for Horizons

A recent precise formulation of the hoop conjecture in four spacetime dimensions is that the Birkhoff invariant $\beta$ (the least maximal length of any sweepout or foliation by circles) of an apparent horizon of energy $E$ and area $A$ should satisfy $\beta \le 4 \pi E$. This conjecture together with the Cosmic Censorship or Isoperimetric inequality implies that the length $\ell$ of the shortest non-trivial closed geodesic satisfies $\ell^2 \le \pi A$. We have tested these conjectures on the horizons of all four-charged rotating black hole solutions of ungauged supergravity theories and find that they always hold. They continue to hold in the the presence of a negative cosmological constant, and for multi-charged rotating solutions in gauged supergravity. Surprisingly, they also hold for the Ernst-Wild static black holes immersed in a magnetic field, which are asymptotic to the Melvin solution. In five spacetime dimensions we define $\beta$ as the least maximal area of all sweepouts of the horizon by two-dimensional tori, and find in all cases examined that $\beta(g) \le \frac{16 \pi}{3} E$, which we conjecture holds quiet generally for apparent horizons. In even spacetime dimensions $D=2N+2$, we find that for sweepouts by the product $S^1 \times S^{D-4}$, $\beta$ is bounded from above by a certain dimension-dependent multiple of the energy $E$. We also find that $\ell^{D-2}$ is bounded from above by a certain dimension-dependent multiple of the horizon area $A$. Finally, we show that $\ell^{D-3}$ is bounded from above by a certain dimension-dependent multiple of the energy, for all Kerr-AdS black holes.Comment: 25 page

Association between leukocyte telomere shortening and exposure to traffic pollution: a cross-sectional study on traffic officers and indoor office workers

BACKGROUND: Telomere shortening in blood leukocytes has been associated with increased morbidity and death from cardiovascular disease and cancer, but determinants of shortened telomeres, a molecular feature of biological aging, are still largely unidentified. Traffic pollution has been linked with both cardiovascular and cancer risks, particularly in older subjects. Whether exposure to traffic pollution is associated with telomere shortening has never been evaluated. METHODS: We measured leukocyte telomere length (LTL) by real-time PCR in blood DNA from 77 traffic officers exposed to high levels of traffic pollutants and 57 office workers (referents). Airborne benzene and toluene, as tracers for traffic exposure, were measured using personal passive samplers and gas-chromatography/flame-ionization detector analysis. We used covariate-adjusted multivariable models to test the effects of the exposure on LTL and obtain adjusted LTL means and 95\% Confidence Intervals (CIs). RESULTS: Adjusted mean LTL was 1.10 (95\%CI 1.04-1.16) in traffic officers and 1.27 in referents (95\%CI 1.20-1.35) [p < 0.001]. LTL decreased in association with age in both traffic officers (p = 0.01) and referents (p = 0.001), but traffic officers had shorter LTL within each age category. Among traffic officers, adjusted mean relative LTL was shorter in individuals working in high (n = 45, LTL = 1.02, 95\%CI 0.96-1.09) compared to low traffic intensity (n = 32, LTL = 1.22, 95\%CI 1.13-1.31) [p < 0.001]. In the entire study population, LTL decreased with increasing levels of personal exposure to benzene (p = 0.004) and toluene (p = 0.008). CONCLUSION: Our results indicate that leukocyte telomere length is shortened in subjects exposed to traffic pollution, suggesting evidence of early biological aging and disease risk