The first cosmic ray albedo proton map of the Moon

[1] Neutrons emitted from the Moon are produced by the impact of galactic cosmic rays (GCRs) within the regolith. GCRs are high-energy particles capable of smashing atomic nuclei in the lunar regolith and producing a shower of energetic protons, neutrons and other subatomic particles. Secondary particles that are ejected out of the regolith become “albedo” particles. The neutron albedo has been used to study the hydrogen content of the lunar regolith, which motivates our study of albedo protons. In principle, the albedo protons should vary as a function of the input GCR source and possibly as a result of surface composition and properties. During the LRO mission, the total detection rate of albedo protons between 60 MeV and 150 MeV has been declining since 2009 in parallel with the decline in the galactic cosmic ray flux, which validates the concept of an albedo proton source. On the other hand, the average yield of albedo protons has been increasing as the galactic cosmic ray spectrum has been hardening, consistent with a disproportionately stronger modulation of lower energy GCRs as solar activity increases. We construct the first map of the normalized albedo proton emission rate from the lunar surface to look for any albedo variation that correlates with surface features. The map is consistent with a spatially uniform albedo proton yield to within statistical uncertainties

Measurements of galactic cosmic ray shielding with the CRaTER instrument

[1] The Cosmic Ray Telescope for the Effects of Radiation (CRaTER) instrument aboard the Lunar Reconnaissance Orbiter has been measuring energetic charged particles from the galactic cosmic rays (GCRs) and solar particle events in lunar orbit since 2009. CRaTER includes three pairs of silicon detectors, separated by pieces of tissue-equivalent plastic that shield two of the three pairs from particles incident at the zenith-facing end of the telescope. Heavy-ion beams studied in previous ground-based work have been shown to be reasonable proxies for the GCRs when their energies are sufficiently high. That work, which included GCR simulations, led to predictions for the amount of dose reduction that would be observed by CRaTER. Those predictions are compared to flight data obtained by CRaTER in 2010–2011

Precise Detections of Solar Particle Events and a New View of the Moon

We have invented a new method for detecting solar particle events using data from the Cosmic Ray Telescope for the Effects of Radiation (CRaTER) on the Lunar Reconnaissance Orbiter (LRO). Using a simple function of the total particle detection rates from four of CRaTER’s six detectors, we can precisely identify solar energetic particle event periods in the CRaTER data archive. During solar quiet periods we map the distribution of a mare‐associated mixture of elements in the lunar regolith using this new method. The new map of the moon probably reflects an as‐yet unknown combination of lunar albedo protons, neutrons, and gamma rays, and most closely resembles Lunar Prospector maps of gamma rays characteristic of thorium and iron. This result will lead to multiple follow‐up studies of lunar albedo particles and may also contribute to the study of diurnally varying hydrogenation of the lunar regolith.Key PointsThe CRaTER instrument on LRO can detect and quantify small solar particle events with a simple new analysis techniqueOur new lunar map of albedo radiation resembles gamma ray maps from Lunar ProspectorFollow‐up studies will investigate contributions from neutrons, protons, and gamma rays, and signatures of hydrogen in lunar regolithPeer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/152796/1/grl60033_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/152796/2/grl60033.pd

Airborne gravity and precise positioning for geologic applications

Airborne gravimetry has become an important geophysical tool primarily because of advancements in methodology and instrumentation made in the past decade. Airborne gravity is especially useful when measured in conjunction with other geophysical data, such as magnetics, radar, and laser altimetry. The aerogeophysical survey over the West Antarctic ice sheet described in this paper is one such interdisciplinary study. This paper outlines in detail the instrumentation, survey and data processing methodology employed to perform airborne gravimetry from the multiinstrumented Twin Otter aircraft. Precise positioning from carrier-phase Global Positioning System (GPS) observations are combined with measurements of acceleration made by the gravity meter in the aircraft to obtain the free-air gravity anomaly measurement at aircraft altitude. GPS data are processed using the Kinematic and Rapid Static (KARS) software program, and aircraft vertical acceleration and corrections for gravity data reduction are calculated from the GPS position solution. Accuracies for the free-air anomaly are determined from crossover analysis after significant editing (2.98 mGal rms) and from a repeat track (1.39 mGal rms). The aerogeophysical survey covered a 300,000 km2 region in West Antarctica over the course of five field seasons. The gravity data from the West Antarctic survey reveal the major geologic structures of the West Antarctic rift system, including the Whitmore Mountains, the Byrd Subglacial Basin, the Sinuous Ridge, the Ross Embayment, and Siple Dome. These measurements, in conjunction with magnetics and ice-penetrating radar, provide the information required to reveal the tectonic fabric and history of this important region

Measurements of galactic cosmic ray shielding with the CRaTER instrument

[1] The Cosmic Ray Telescope for the Effects of Radiation (CRaTER) instrument aboard the Lunar Reconnaissance Orbiter has been measuring energetic charged particles from the galactic cosmic rays (GCRs) and solar particle events in lunar orbit since 2009. CRaTER includes three pairs of silicon detectors, separated by pieces of tissue-equivalent plastic that shield two of the three pairs from particles incident at the zenith-facing end of the telescope. Heavy-ion beams studied in previous ground-based work have been shown to be reasonable proxies for the GCRs when their energies are sufficiently high. That work, which included GCR simulations, led to predictions for the amount of dose reduction that would be observed by CRaTER. Those predictions are compared to flight data obtained by CRaTER in 2010-2011

Deciphering von Hippel-Lindau (VHL/Vhl)-Associated Pancreatic Manifestations by Inactivating Vhl in Specific Pancreatic Cell Populations

The von Hippel-Lindau (VHL) syndrome is a pleomorphic familial disease characterized by the development of highly vascularized tumors, such as hemangioblastomas of the central nervous system, pheochromocytomas, renal cell carcinomas, cysts and neuroendocrine tumors of the pancreas. Up to 75% of VHL patients are affected by VHL-associated pancreatic lesions; however, very few reports in the published literature have described the cellular origins and biological roles of VHL in the pancreas. Since homozygous loss of Vhl in mice resulted in embryonic lethality, this study aimed to characterize the functional significance of VHL in the pancreas by conditionally inactivating Vhl utilizing the Cre/LoxP system. Specifically, Vhl was inactivated in different pancreatic cell populations distinguished by their roles during embryonic organ development and their endocrine lineage commitment. With Cre recombinase expression directed by a glucagon promoter in α-cells or an insulin promoter in β-cells, we showed that deletion of Vhl is dispensable for normal functions of the endocrine pancreas. In addition, deficiency of VHL protein (pVHL) in terminally differentiated α-cells or β-cells is insufficient to induce pancreatic neuroendocrine tumorigenesis. Most significantly, we presented the first mouse model of VHL-associated pancreatic disease in mice lacking pVHL utilizing Pdx1-Cre transgenic mice to inactivate Vhl in pancreatic progenitor cells. The highly vascularized microcystic adenomas and hyperplastic islets that developed in Pdx1-Cre;Vhl f/f homozygous mice exhibited clinical features similar to VHL patients. Establishment of three different, cell-specific Vhl knockouts in the pancreas have allowed us to provide evidence suggesting that VHL is functionally important for postnatal ductal and exocrine pancreas, and that VHL-associated pancreatic lesions are likely to originate from progenitor cells, not mature endocrine cells. The novel model systems reported here will provide the basis for further functional and genetic studies to define molecular mechanisms involved in VHL-associated pancreatic diseases

Development and testing of innovative patient resources for the management of coronary heart disease (CHD): a descriptive study

BACKGROUND: Although heart disease is a major cause of morbidity and mortality the majority of patients do not access existing rehabilitation programs and patient resources are not designed to facilitate patient choice and decision-making. The objective of this study was to develop and test a series of risk factor modules and corresponding patient information leaflets for secondary prevention of CHD. METHODS: In phase one, a series of risk factor modules and management options were developed following analysis of literature and interviews with health professionals. In phase two, module information leaflets were developed using published guidelines and interviews of people with CHD. In phase three, the leaflets were tested for quality (DISCERN), readability (Flesch) and suitability (SAM) and were compared to the existing cardiac rehabilitation (CR) information leaflet. Finally, the patients assessed the leaflets for content and relevance. RESULTS: Four key risk factors identified were cholesterol, blood pressure, smoking and physical inactivity. Choice management options were selected for each risk factor and included medical consultation, intensive health professional led program, home program and self direction. Patient information needs were then identified and leaflets were developed. DISCERN quality scores were high for cholesterol (62/80), blood pressure (59/80), smoking (62/80) and physical activity (62/80), all scoring 4/5 for overall rating. The mean Flesch readability score was 75, representing "fairly easy to read", all leaflets scored in the superior category for suitability and were reported to be easy to understand, useful and motivating by persons with CHD risk factors. The developed leaflets scored higher on each assessment than the existing CR leaflets. CONCLUSION: Using a progressive three phase approach, a series of risk factor modules and information leaflets were successfully developed and tested. The leaflets will contribute to shared-decision making and empowerment for persons with CHD

Speech Communication

Contains reports on five research projects.C.J. Lebel FellowshipNational Institutes of Health (Grant 5 T32 NSO7040)National Institutes of Health (Grant 5 R01 NS04332)National Institutes of Health (Grant 5 R01 NS21183)National Institutes of Health (Grant 5 P01 NS13126)National Institutes of Health (Grant 1 PO1-NS23734)National Science Foundation (Grant BNS 8418733)U.S. Navy - Naval Electronic Systems Command (Contract N00039-85-C-0254)U.S. Navy - Naval Electronic Systems Command (Contract N00039-85-C-0341)U.S. Navy - Naval Electronic Systems Command (Contract N00039-85-C-0290)National Institutes of Health (Grant RO1-NS21183), subcontract with Boston UniversityNational Institutes of Health (Grant 1 PO1-NS23734), subcontract with the Massachusetts Eye and Ear Infirmar

Speech Communication

Contains table of contents for Part IV, table of contents for Section 1, an introduction, reports on seven research projects and a list of publications.C.J. Lebel FellowshipDennis Klatt Memorial FundNational Institutes of Health Grant T32-DC00005National Institutes of Health Grant R01-DC00075National Institutes of Health Grant F32-DC00015National Institutes of Health Grant R01-DC00266National Institutes of Health Grant P01-DC00361National Institutes of Health Grant R01-DC00776National Science Foundation Grant IRI 89-10561National Science Foundation Grant IRI 88-05680National Science Foundation Grant INT 90-2471