2,780 research outputs found
Theory and applications of supercycled symmetry-based recoupling sequences in solid-state NMR
We present the theoretical principles of supercycled symmetry-based recoupling sequences in solid-state magic-angle-spinning NMR. We discuss the construction procedure of the SR26 pulse sequence, which is a particularly robust sequence for double-quantum homonuclear dipole-dipole recoupling. The supercycle removes destructive higher-order average Hamiltonian terms and renders the sequence robust over long time intervals. We demonstrate applications of the SR26 sequence to double-quantum spectroscopy, homonuclear spin counting, and determination of the relative orientations of chemical shift anisotropy tensors
Fidelity, dynamic structure factor, and susceptibility in critical phenomena
Motivated by the growing importance of fidelity in quantum critical
phenomena, we establish a general relation between fidelity and structure
factor of the driving term in a Hamiltonian through a newly introduced concept:
fidelity susceptibility. Our discovery, as shown by some examples, facilitates
the evaluation of fidelity in terms of susceptibility using well developed
techniques such as density matrix renormalization group for the ground state,
or Monte Carlo simulations for the states in thermal equilibrium.Comment: 4 pages, 2 figures, final version accepted by PR
A note on Zolotarev optimal rational approximation for the overlap Dirac operator
We discuss the salient features of Zolotarev optimal rational approximation
for the inverse square root function, in particular, for its applications in
lattice QCD with overlap Dirac quark. The theoretical error bound for the
matrix-vector multiplication is derived. We check that
the error bound is always satisfied amply, for any QCD gauge configurations we
have tested. An empirical formula for the error bound is determined, together
with its numerical values (by evaluating elliptic functions) listed in Table 2
as well as plotted in Figure 3. Our results suggest that with Zolotarev
approximation to , one can practically preserve the exact
chiral symmetry of the overlap Dirac operator to very high precision, for any
gauge configurations on a finite lattice.Comment: 23 pages, 5 eps figures, v2:minor clarifications, and references
added, to appear in Phys. Rev.
High energy neutrinos from neutralino annihilations in the Sun
Neutralino annihilations in the Sun to weak boson and top quark pairs lead to
high-energy neutrinos that can be detected by the IceCube and KM3 experiments
in the search for neutralino dark matter. We calculate the neutrino signals
from real and virtual WW, ZZ, Zh, and production and decays,
accounting for the spin-dependences of the matrix elements, which can have
important influences on the neutrino energy spectra. We take into account
neutrino propagation including neutrino oscillations, matter-resonance,
absorption, and nu_tau regeneration effects in the Sun and evaluate the
neutrino flux at the Earth. We concentrate on the compelling Focus Point (FP)
region of the supergravity model that reproduces the observed dark matter relic
density. For the FP region, the lightest neutralino has a large bino-higgsino
mixture that leads to a high neutrino flux and the spin-dependent neutralino
capture rate in the Sun is enhanced by 10^3 over the spin-independent rate. For
the standard estimate of neutralino captures, the muon signal rates in IceCube
are identifiable over the atmospheric neutrino background for neutralino masses
above M_Z up to 400 GeV.Comment: 45 pages, 18 figures and 5 tables, PRD versio
CP asymmetry in the Higgs decay into the top pair due to the stop mixing
We investigate a potentially large CP violating asymmetry in the decay of a
neutral scalar or pseudoscalar Higgs boson into the top-anti-top pair. The
source of the CP nonconservation is the complex mixing in the (left-right) stop
sector. One of the interesting consequence is the different rates of the Higgs
boson decays into CP conjugate polarized states.Comment: 14 pages, 8 figures include
Microstructured Fibre Taper with Constant Outer Diameter
Department of Electrical Engineerin
Plasmodium falciparum ligand binding to erythrocytes induce alterations in deformability essential for invasion
The most lethal form of malaria in humans is caused by Plasmodium falciparum. These parasites invade erythrocytes, a complex process involving multiple ligand-receptor interactions. The parasite makes initial contact with the erythrocyte followed by dramatic deformations linked to the function of the Erythrocyte binding antigen family and P. falciparum reticulocyte binding-like families. We show EBA-175 mediates substantial changes in the deformability of erythrocytes by binding to glycophorin A and activating a phosphorylation cascade that includes erythrocyte cytoskeletal proteins resulting in changes in the viscoelastic properties of the host cell. TRPM7 kinase inhibitors FTY720 and waixenicin A block the changes in the deformability of erythrocytes and inhibit merozoite invasion by directly inhibiting the phosphorylation cascade. Therefore, binding of P. falciparum parasites to the erythrocyte directly activate a signaling pathway through a phosphorylation cascade and this alters the viscoelastic properties of the host membrane conditioning it for successful invasion
Accuracy of Semiclassical Methods for Shape Invariant Potentials
We study the accuracy of several alternative semiclassical methods by
computing analytically the energy levels for many large classes of exactly
solvable shape invariant potentials. For these potentials, the ground state
energies computed via the WKB method typically deviate from the exact results
by about 10%, a recently suggested modification using nonintegral Maslov
indices is substantially better, and the supersymmetric WKB quantization method
gives exact answers for all energy levels.Comment: 7 pages, Latex, and two tables in postscrip
A practical implementation of the Overlap-Dirac operator
A practical implementation of the Overlap-Dirac operator
is presented. The implementation exploits
the sparseness of and does not require full storage. A simple application
to parity invariant three dimensional SU(2) gauge theory is carried out to
establish that zero modes related to topology are exactly reproduced on the
lattice.Comment: Y-axis label in figure correcte
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Interaction between galectin-3 and cystinosin uncovers a pathogenic role of inflammation in kidney involvement of cystinosis.
Inflammation is involved in the pathogenesis of many disorders. However, the underlying mechanisms are often unknown. Here, we test whether cystinosin, the protein involved in cystinosis, is a critical regulator of galectin-3, a member of the β-galactosidase binding protein family, during inflammation. Cystinosis is a lysosomal storage disorder and, despite ubiquitous expression of cystinosin, the kidney is the primary organ impacted by the disease. Cystinosin was found to enhance lysosomal localization and degradation of galectin-3. In Ctns-/- mice, a mouse model of cystinosis, galectin-3 is overexpressed in the kidney. The absence of galectin-3 in cystinotic mice ameliorates pathologic renal function and structure and decreases macrophage/monocyte infiltration in the kidney of the Ctns-/-Gal3-/- mice compared to Ctns-/- mice. These data strongly suggest that galectin-3 mediates inflammation involved in kidney disease progression in cystinosis. Furthermore, galectin-3 was found to interact with the pro-inflammatory cytokine Monocyte Chemoattractant Protein-1, which stimulates the recruitment of monocytes/macrophages, and proved to be significantly increased in the serum of Ctns-/- mice and also patients with cystinosis. Thus, our findings highlight a new role for cystinosin and galectin-3 interaction in inflammation and provide an additional mechanistic explanation for the kidney disease of cystinosis. This may lead to the identification of new drug targets to delay cystinosis progression
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