ASSESSING THE IMPACTS OF CLIMATE CHANGE ON THE HYDROLOGY OF THE INDRAWATI RIVER BASIN, NEPAL

Abstract. This study details climate change assessment of the hydrological regime of Indrawati basin of Nepal. The study uses Soil and Water Assessment Tool (SWAT) model to delineate, discretize and parameterize the Indrawati basin to compute model's input parameters. The model was then run for 1990–2014 to simulate the discharge at the outlet (Dholalghat). The coefficient of determination R2 and Nash-Sutcliffe (ENS) were used to evaluate model calibration and validation. The results found were satisfactory for the gauging station R2 = 0.951 and ENS = 0.901 for calibration and R2 = 0.937 and. ENS = 0.906 for validation. The calibrated hydrological model was run for the future climate change scenario using the RegCM4-LMDZ4 data and the relative changes with the baseline scenarios were analyzed. The comparison suggests that the historical trend of flow is decreasing at the rate of 0.55 m3/s per year. According to RegCM4-LMDZ4 simulations, the trend is going to continue but at a flatter rate. The decreasing trend is observed to be very less. The characteristic peak flow month in the historical scenario is August but the RegCM4-LMDZ4 led simulated flows suggest a shift in monthly peak to October suggesting decrease in monsoon flows and a subsequent significant increase in flows from October to January

Viewpoint – Pouring money down the drain: Can we break the habit by reconceiving wastes as resources?

As water-sector professionals re-discover the value in the 'waste' conveyed in 'waste'water, this Viewpoint argues that the theory of plural rationality (also known as Cultural Theory) may accelerate the switch from waste management to resource recovery. Accordingly, it extends the framing of plural rationality, from its traditional applications in matters of governance and social and economic analysis, to the beginnings of a set of plural schools of engineering thought. This sounds controversial. Indeed, we hope it is. For all too often ways to resolve water issues end up in the impasse of two deeply entrenched positions: the 'technocratic reductionism' of the 'quick engineering fix' to problem solving; and the 'participatory holism' of the 'local, socially sensitive, integrationist' approach. Plural rationality sees this is an impoverished duopoly. Our very strong preference is to find ways of promoting the creative interplay among plural (more than two), mutually opposed, contending ways of framing a problem and resolving it. This, we argue, should not only expand the portfolio of possible alternatives for technology-policy interventions, but also lead to the chosen alternative being preferable — in social, economic, and environmental terms — to what might otherwise have happened. Such solutions are called 'clumsy' in plural rationality theory. We use a synopsis of a case history of restoring water quality in the River Rhine in Europe, within a wider account of the sweep of resource recovery spanning two centuries (late 18th Century through early 21st Century), to illustrate how clumsiness works. This, however, does not extend to our elaborating our proposed set of plural schools of engineering thought beyond just its very beginnings. Our Viewpoint allows us merely to start framing the challenge of developing, and eventually applying, such a notion

Plant breeding can be made more efficient by having fewer, better crosses

BACKGROUND: Crop yields have to increase to provide food security for the world’s growing population. To achieve these yield increases there will have to be a significant contribution from genetic gains made by conventional plant breeding. However, the breeding process is not efficient because crosses made between parental combinations that fail to produce useful varieties consume over 99% of the resources. RESULTS: We tested in a rice-breeding programme if its efficiency could be improved by using many fewer, but more judiciously chosen crosses than usual. In a 15-year programme in Nepal, with varietal testing also in India and Bangladesh, we made only six crosses that were stringently chosen on complementary parental performance. We evaluated their success by the adoption and official release of the varieties they produced. We then modelled optimum cross number using assumptions based on our experimental results. Four of the six crosses succeeded. This was a fifty-fold improvement over breeding programmes that employ many crosses where only about one, or fewer, crosses in 200 succeed. Based on these results, we modelled the optimum number of crosses by assuming there would be a decline in the reliability of the breeder’s prediction of the value of each cross as more crosses were made (because there is progressively less information on the traits of the parents). Fewer-cross programmes were more likely to succeed and did so using fewer resources. Making more crosses reduced the overall probability of success of the breeding programme. CONCLUSIONS: The efficiency of national and international breeding programmes would be increased by making fewer crosses among more carefully chosen parents. This would increase the number of higher yielding varieties that are delivered to farmers and hence help to improve food security

STUDY OF RIVER CHANNEL MIGRATION AND IDENTIFICATION OF POTENTIAL SUGARCANE CULTIVATION AREA IN THE MOHANA-MACHELI WATERSHED USING REMOTE SENSING

Channel migration becomes the main characteristic of major rivers of Mohana-Macheli watershed of western Nepal. Study of river channel migration of major rivers of watershed using freely available remote sensing show that the channel has shifted to as high as 1000 meters from the original river path over the span of 9 years (2009–2017). The channel migration directly affects the land use and it has direct effect on the flood plain settlements of the study area. Cultivation of sugarcane in sand area is one of the mitigating measures of flood effects and prevent river bank erosion. The study shows that the area of sand is changing disproportionately in the region. This paper presents an enhanced change detection method of river channel migration using remotely sensed images and identification of sand area using classification and interpretation technique

Improving the diagnostic yield of high-resolution esophageal manometry for GERD: The straight leg-raise international study

BACKGROUND & AIMS: The straight leg raise (SLR) maneuver during high-resolution manometry (HRM) can assess esophagogastric junction (EGJ) barrier function by measuring changes in intraesophageal pressure (IEP) when intra-abdominal pressure is increased. We aimed to determine whether increased esophageal pressure during SLR predicts pathologic esophageal acid exposure time (AET). METHODS: Adult patients with persistent gastroesophageal reflux disease (GERD) symptoms undergoing HRM and pH-impedance or wireless pH study off proton pump inhibitor were prospectively studied between July 2021 and March 2022. After the HRM Chicago 4.0 protocol, patients were requested to elevate 1 leg at 45º for 5 seconds while supine. The SLR maneuver was considered effective when intra-abdominal pressure increased by 50%. IEPs were recorded 5 cm above the lower esophageal sphincter at baseline and during SLR. GERD was defined as AET greater than 6%. RESULTS: The SLR was effective in 295 patients (81%), 115 (39%) of whom had an AET greater than 6%. Hiatal hernia (EGJ type 2 or 3) was seen in 135 (46%) patients. Compared with patients with an AET less than 6%, peak IEP during SLR was significantly higher in the GERD group (29.7 vs 13.9 mm Hg; P \u3c .001). Using receiver operating characteristic analysis, an increase of 11 mm Hg of peak IEP from baseline during SLR was the optimal cut-off value to predict an AET greater than 6% (area under the receiver operating characteristic curve, 0.84; sensitivity, 79%; and specificity, 85%), regardless of the presence of hiatal hernia. On multivariable analysis, an IEP pressure increase during the SLR maneuver, EGJ contractile integral, EGJ subtype 2, and EGJ subtype 3, were found to be significant predictors of AET greater than 6% CONCLUSIONS: The SLR maneuver can predict abnormal an AET, thereby increasing the diagnostic value of HRM when GERD is suspected. CLINICALTRIALS: gov ID: NCT04813029

Application of single-level and multi-level modeling approach to examine geographic and socioeconomic variation in underweight, overweight and obesity in Nepal: findings from NDHS 2016

© 2020, The Author(s). Nepal’s dual burden of undernutrition and over nutrition warrants further exploration of the population level differences in nutritional status. The study aimed to explore, for the first time in Nepal, potential geographic and socioeconomic variation in underweight and overweight and/or obesity prevalence in the country, adjusted for cluster and sample weight. Data came from 14,937 participants, including 6,172 men and 8,765 women, 15 years or older who participated in the 2016 Nepal Demography and Health Survey (NDHS). Single-level and multilevel multi-nominal logistic regression models and Lorenz curves were used to explore the inequalities in weight status. Urban residents had higher odds of being overweight and/or obese (OR: 1.89, 95% CI: 1.62–2.20) and lower odds of being underweight (OR: 0.81, 95% CI: 0.70–0.93) than rural residents. Participants from Provinces 2, and 7 were less likely to be overweight/obese and more likely to be underweight (referent: province-1). Participants from higher wealth quintile households were associated with higher odds of being overweight and/or obese (P-trend < 0.001) and lower odds of being underweight (P-trend < 0.001). Urban females at the highest wealth quintile were more vulnerable to overweight and/or obesity as 49% of them were overweight and/or obese and nearly 39% at the lowest wealth quintile were underweight

Distributions of fecal markers in wastewater from different climatic zones for human fecal pollution tracking in Australian surface waters

Recreational and potable water supplies polluted with human wastewater can pose a direct health risk to humans. Therefore, sensitive detection of human fecal pollution in environmental waters is very important to water quality authorities around the globe. Microbial source tracking (MST) utilizes human fecal markers (HFMs) to detect human wastewater pollution in environmental waters. The concentrations of these markers in raw wastewater are considered important because it is likely that a marker whose concentration is high in wastewater will be more frequently detected in polluted waters. In this study, quantitative PCR (qPCR) assays were used to determine the concentrations of fecal indicator bacteria (FIB) Escherichia coli and Enterococcus spp., HFMs Bacteroides HF183, human adenoviruses (HAdVs), and polyomaviruses (HPyVs) in raw municipal wastewater influent from various climatic zones in Australia. E. coli mean concentrations in pooled human wastewater data sets (from various climatic zones) were the highest (3.2 × 10 gene copies per ml), followed by those of HF183 (8.0 × 10 gene copies per ml) and Enterococcus spp. (3.6 × 10 gene copies per ml). HAdV and HPyV concentrations were 2 to 3 orders of magnitude lower than those of FIB and HF183. Strong positive and negative correlations were observed between the FIB and HFM concentrations within and across wastewater treatment plants (WWTPs). To identify the most sensitive marker of human fecal pollution, environmental water samples were seeded with raw human wastewater. The results from the seeding experiments indicated that Bacteroides HF183 was more sensitive for detecting human fecal pollution than HAdVs and HPyVs. Since the HF183 marker can occasionally be present in nontarget animal fecal samples, it is recommended that HF183 along with a viral marker (HAdVs or HPyVs) be used for tracking human fecal pollution in Australian environmental waters

Hormonal profile and efficacy of long pulse Nd-YAG laser in treatment of hirsutism

Background: Hormones, particularly androgens play a vital role in hair growth, differentiation and distribution. Hirsutism is a common entity among Nepalese population with skin types III, IV and V. Long pulsed lasers are commonly used for hair removal. Methods: This is a prospective analytical study done in Dhulikhel Hospital Kathmandu University Hospital, Kavre, Nepal from November 2010 to November 2011. Patients were first subjected to hormonal evaluation. Androgens, their tropic hormones, insulin resistance markers and endocrine components were measured and compared. Subjects were then categorized into two groups according to androgen levels: group A (n=30) with significantly high androgen (total testosterone and dehydroepiandrosterone sulfate) or elevated luteinizing hormone: follicle stimulating hormone ratio, consistent with Polycystic Ovarian Syndrome (PCOS) and group B (n=30). Adrenal tumour was ruled out in all patients. All patients received long pulse Nd-YAG laser (50J/cm2; 50 msec pulse duration) therapy at four weeks interval to achieve at least 50% hair reduction. Results: Among group A patients, average 8.1 treatment sessions were required for substantial hair reduction, whereas, average 5.7 sessions produced similar results in group B patients (p-value <0.05). Conclusions: Patients with high androgen level and elevated LH: FSH ratio requires more treatment sessions for hair removal with long pulsed ND-YAG laser than patients with normal or low hormone level.Karn D, KC S, Timalsina M, Gyawali

Preservation of geochemical characteristics in Permo-Triassic mudstones by metagenesis and low-grade metamorphism in the Tethys Himalaya, Central Nepal

Abstract HKT-ISTP 2013 A

Toolbox approaches using molecular markers and 16S rRNA gene amplicon data sets for identification of fecal pollution in surface water

In this study, host-associated molecular markers and bacterial 16S rRNA gene community analysis using high-throughput sequencing were used to identify the sources of fecal pollution in environmental waters in Brisbane, Australia. A total of 92 fecal and composite wastewater samples were collected from different host groups (cat, cattle, dog, horse, human, and kangaroo), and 18 water samples were collected from six sites (BR1 to BR6) along the Brisbane River in Queensland, Australia. Bacterial communities in the fecal, wastewater, and river water samples were sequenced. Water samples were also tested for the presence of bird-associated (GFD), cattle-associated (CowM3), horse-associated, and human-associated (HF183) molecular markers, to provide multiple lines of evidence regarding the possible presence of fecal pollution associated with specific hosts. Among the 18 water samples tested, 83%, 33%, 17%, and 17% were real-time PCR positive for the GFD, HF183, CowM3, and horse markers, respectively. Among the potential sources of fecal pollution in water samples from the river, DNA sequencing tended to show relatively small contributions from wastewater treatment plants (up to 13% of sequence reads). Contributions from other animal sources were rarely detected and were very small